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  4. Recombinant Mouse Interferon-induced transmembrane protein 5 (Ifitm5), partial

Recombinant Mouse Interferon-induced transmembrane protein 5 (Ifitm5), partial

  • 中文名称：
    小鼠Ifitm5重组蛋白
  • 货号：
    CSB-YP011028MO1
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Ifitm5重组蛋白
  • 货号：
    CSB-EP011028MO1
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Ifitm5重组蛋白
  • 货号：
    CSB-EP011028MO1-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Ifitm5重组蛋白
  • 货号：
    CSB-BP011028MO1
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Ifitm5重组蛋白
  • 货号：
    CSB-MP011028MO1
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Ifitm5
  • Uniprot No.：
  • 别名：
    Ifitm5; Bril; Fragilis4; Interferon-induced transmembrane protein 5; Bone-restricted interferon-induced transmembrane protein-like protein; Dispanin subfamily A member 1; DSPA1; Fragilis family member 4
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Required for normal bone mineralization.
  • 基因功能参考文献：
    1. results suggest that expression of mutant IFITM5 causes abnormal skeletal development, low bone mass, and abnormal osteoblast differentiation PMID: 25251575
    2. The purpose of the current study was to re-assess the topology, localization, and biochemical properties of BRIL and compare it to the osteogenesis imperfecta type V mutant in MC3T3 osteoblasts. PMID: 24715519
    3. These results indicate that the S-palmitoylation on IFITM5 promotes the interaction with FKBP11. PMID: 24058703
    4. Key roles for the Sp members and GLI2 that possibly cooperate to activate Bril when the promoter becomes demethylated. PMID: 23530031
    5. Natural antisense transcripts enhance bone formation by increasing sense IFITM5 transcription. PMID: 22884724
    6. Ifitm5 deficiency might have a greater effect on prenatal bone development. PMID: 20838829
    7. these results suggest that IFITM5 is involved not only in bone formation, but also in immune system activity. PMID: 21600883
    8. Bril is a novel osteoblast protein and showed a role in mineralization, possibly identifying a new regulatory pathway in bone formation. PMID: 18442316

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  • 亚细胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    CD225/Dispanin family
  • 组织特异性：
    Detected in embryonic bone (at protein level). Highly expressed in osteoblasts of adults and embryos. Expressed in primitive hemopoietic cells.
  • 数据库链接：

    KEGG: mmu:73835

    STRING: 10090.ENSMUSP00000026562

    UniGene: Mm.389989