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  4. Recombinant Mouse Interferon-induced protein with tetratricopeptide repeats 3 (Ifit3)

Recombinant Mouse Interferon-induced protein with tetratricopeptide repeats 3 (Ifit3)

  • 货号：
    CSB-YP011022MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP011022MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP011022MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP011022MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP011022MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Ifit3
  • Uniprot No.：
  • 别名：
    Ifit3; Garg49; Ifi49; Isg49Interferon-induced protein with tetratricopeptide repeats 3; IFIT-3; Glucocorticoid-attenuated response gene 49 protein; GARG-49; P49; IRG2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-403
  • 氨基酸序列
    MSEVNRESLE AILPQLKCHF TWNLFREGSM SSHMEDRVCN QVEHLNSEEK ATMYDLLAYI KHLDGESKAA LECLGQAEDL RKSEHNDQSE IRRLVTWGNY AWIYYHMGRL SEAQAYVDKV RQVCQKFANP YSMECPELEC EEGWTRLKCG RNERAKMCFE KALEEKPKDP ECSSGMAIAM FRLEEKPEKQ FSVDALKQAM ELNPQNQYLK VLLALKLLRM GEEAEGERLI KDALGKAPNQ TDVLQKAAQF YKKKGNLDRA IELLGKALRS TVNNSPLYSL VMCRYREILE QLQNKGDADS SERRQRMAEL RRLTMEFMQK TLQRRRSPLN SYSDLIDFPE VERCYQMVIS KESPDVEEED LYERYCNLQE YHRKSEDLAA LECLLQFPRN ERSIEKEEVK EQT
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS-mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exhibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin-dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Upregulates CDKN1A/p21 by downregulating MYC, a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2.
  • 基因功能参考文献：
    1. Expression of interferon-induced protein with tetratricopeptide repeats 3 (Ifit3) is decreased in CD4-Positive T-Lymphocytes from Systemic Lupus Erythematosus-prone mice following TOFA and DEXA treatment. PMID: 28830352
    2. Ifitm3 restricts West Nile virus pathogenesis likely through multiple mechanisms, including the direct control of infection in subsets of cells. PMID: 27384652
  • 亚细胞定位：
    Cytoplasm. Mitochondrion.
  • 蛋白家族：
    IFIT family
  • 数据库链接：

    KEGG: mmu:15959

    STRING: 10090.ENSMUSP00000099889

    UniGene: Mm.426079