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  4. Recombinant Mouse Inactive tyrosine-protein kinase 7 (Ptk7), partial

Recombinant Mouse Inactive tyrosine-protein kinase 7 (Ptk7), partial

  • 货号：
    CSB-YP804364MO
  • 规格：
    ￥1836
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 90% as determined by SDS-PAGE.
  • 基因名：
  • Uniprot No.：
  • 别名：
    Ptk7; Inactive tyrosine-protein kinase 7; Protein chuzhoi; Protein-tyrosine kinase 7; Pseudo tyrosine kinase receptor 7; Tyrosine-protein kinase-like 7
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Extracellular Domain
  • 来源：
    Yeast
  • 分子量：
    78.6kDa
  • 蛋白标签：
    N-terminal 10xHis-tagged and C-terminal Myc-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Tris-based buffer,50% glycerol
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Inactive tyrosine kinase involved in Wnt signaling pathway. Component of both the non-canonical (also known as the Wnt/planar cell polarity signaling) and the canonical Wnt signaling pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis.
  • 基因功能参考文献：
    1. PTK7 regulates extracellular matrix integrity and the activity levels of RAC1 and myosin II, which in turn regulates Wolffian duct morphogenesis and therefore, epididymal function. PMID: 29580943
    2. In a Ptk7-deficient mouse strain, loss of Ptk7 leads to a diminished pool of hematopoietic stem cells but does not affect in vitro or in vivo differentiation. This is correlated with increased quiescence and reduced homing abilities of Ptk7-deficient hematopoietic stem and progenitor cells. PMID: 27183644
    3. Data suggest that protein tyrosine kinase 7 (PTK7) is essential for Wolffian duct morphogenesis and male fertility. PMID: 26944093
    4. data demonstrates that PTK7 regulates the activity of KDR biphasically by inducing oligomerization of KDR molecules at lower concentrations and by surrounding KDR molecules at higher concentrations. PMID: 25986862
    5. PTK7 expression plays an important role in the invasiveness of intrahepatic cholangiocarcinoma cells. PMID: 24587299
    6. Planar polarity of neural cell motility and intercalation requires Ptk7 function. PMID: 24703875
    7. acts in conjunction with the noncanonical Wnt pathway to orient epithelial planar cell polarity through modulation of myosin II-based contractile tension between supporting cells and hair cells PMID: 22560610
    8. The tyrosine kinase receptor, PTK7, is implicated in beta-catenin-dependent developmental processes. PMID: 21415598
    9. These findings illustrate a novel and pivotal role for Cdx function upstream of Ptk7 and neural tube closure in vertebrates. PMID: 21350009
    10. Chuzhoi mutation, that causes multiple abnormalities maps, to Chromosome 17 and carries a splice site mutation in Ptk7 and causes disruption of Ptk7 protein expression. PMID: 20704721
    11. Ptk7 mRNA was expressed at high levels in lung and un-pregnant uterus among adult tissues, and in the tail, limbs, somites, gut, and craniofacial regions among embryonic tissues, and suggest that PTK7 plays multiple roles in embryonic development. PMID: 15019986
    12. a mutation disrupts neural tube closure and stereociliary bundle orientation, and shows genetic interactions with a mutation in the mouse Van Gogh homologue vangl2 PMID: 15229603
    13. polarized cell behaviors underlying CE in the mouse, clearly define specific roles for planar polarity and for the novel planar cell polarity gene, Ptk7, as essential regulators of mediolateral cell intercalation during mammalian CE. PMID: 19439496

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  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein. Cell junction. Note=Colocalizes with MMP14 at cell junctions. Also localizes at the leading edge of migrating cells.
  • 蛋白家族：
    Protein kinase superfamily, Tyr protein kinase family, Insulin receptor subfamily
  • 组织特异性：
    Expressed at high levels in lung and un-pregnant uterus among adult tissues, and in the tail, limbs, somites, gut and craniofacial regions among embryonic tissues.
  • 数据库链接：

    KEGG: mmu:71461

    STRING: 10090.ENSMUSP00000043703

    UniGene: Mm.181833