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  4. Recombinant Mouse Homer protein homolog 2 (Homer2)

Recombinant Mouse Homer protein homolog 2 (Homer2)

  • 货号：
    CSB-YP865573MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP865573MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP865573MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP865573MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP865573MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Homer2; Vesl2; Homer protein homolog 2; Homer-2; Cupidin; VASP/Ena-related gene up-regulated during seizure and LTP 2; Vesl-2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-354
  • 氨基酸序列
    MGEQPIFTTR AHVFQIDPST KKNWVPASKQ AVTVSYFYDV TRNSYRIISV DGAKVIINST ITPNMTFTKT SQKFGQWADS RANTVFGLGF SSELQLTKFA EKFQEVREAA RLARDKSQEK TETSSNHSQE SGCETPSSTQ ASSVNGTDDE KASHASPADT HLKSENDKLK IALTQSAANV KKWEMELQTL RESNARLTTA LQESAASVEQ WKRQFSICRD ENDRLRSKIE ELEEQCSEIN REKEKNTQLK RRIEELESEV RDKEMELKDL RKQSEIIPQL MSECEYVSEK LEAAERDNQN LEDKVRSLKT DIEESKYRQR HLKGELKSFL EVLDGKIDDL HDFRRGLSKL GTDN
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses Required for normal hearing. Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA.
  • 基因功能参考文献：
    1. The present results provide novel cause-effect evidence supporting a role for CEA Homer2 in the regulation of both basal anxiety and the time-dependent intensification of negative affective states in individuals with a history of binge-drinking during adolescence. PMID: 29109058
    2. detected an additional 15 novel Homer2-interacting proteins, most of which are part of the N-methyl-D-aspartate receptor signaling pathway. These results corroborate the central role Homer2 plays in glutamatergic transmission and expand the network of proteins potentially contributing to the behavioral abnormalities associated with altered Homer2 expression PMID: 28728878
    3. stress-alcohol locomotor cross-sensitization was regulated by Homer2. PMID: 25916683
    4. NMDA receptor function, but not ethanol sensitivity, is reduced in hippocampal neurons lacking the Homer2 gene PMID: 26426435
    5. mouse mutants homozygous for the targeted deletion of Homer2 present with early-onset rapidly progressive hearing loss. PMID: 25816005
    6. Findings indicate an important regulation of plasma membrane Ca(2+)-ATPase (PMCA) by Homer2 protein that has a central role on PMCA-mediated Ca(2+) signaling in parotid acinar cells. PMID: 25049230
    7. This study deministrated that PFC Homer2 overexpression enhances cocaine-conditioned reward in mice. PMID: 23658151
    8. Homer 1b/c isoform is identical irrespective of the muscle; Homer 2a/b is instead characteristic of the slow-twitch phenotype. PMID: 23076792
    9. These data support the over-arching hypothesis that augmented accumbens Homer2-mediated glutamate signaling may be an endophenotype related to genetic variance in alcohol consumption PMID: 20807241
    10. Homer2 tunes G protein-coupled receptors stimulus intensity by regulating RGS proteins and PLCbeta GAP activities. PMID: 12860966
    11. In the developing olfactory bulb, Cupidin/Homer 2a/b is up-regulated in the granular, external plexiform, and glomerular layers PMID: 15116392
    12. Homer2 KO mice demonstrate enhanced locomotor stimulant and conditioned place preference responses to cocaine PMID: 15545022
    13. necessary and active role for accumbens Homer2 expression in regulating EtOH-induced behavioral and cellular neuroplasticity PMID: 16049182
    14. Expression of HOMER2 enhanced the ability of MYO18B to suppress anchorage-independent growth. These results indicate that HOMER2 and MYO18B cooperate together in tumor suppression. PMID: 17386922
    15. Accumbens Homer2 overexpression facilitates alcohol-induced neuroplasticity in C57BL/6J mice. PMID: 17568396
    16. study found that Homer2 and Homer3 are negative regulators of T cell activation; this is achieved through binding of nuclear factor of activated T cells (NFAT) and by competing with calcineurin PMID: 18218901
    17. Homer2 and Homer3 proteins interact specifically with amyloid precursor protein (APP) by inhibiting APP processing and reducing secretion of Abeta peptides. PMID: 18387811

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  • 亚细胞定位：
    Cytoplasm. Cell membrane. Cell junction, synapse, postsynaptic density. Cell junction, synapse. Cell projection, stereocilium. Note=Postsynaptic density of neuronal cells. The stabilization and clustering of the metabotropic glutamate receptors appears to be mediated by isoform 1 and isoform 2 at the cell surface.
  • 蛋白家族：
    Homer family
  • 组织特异性：
    Expressed in olfactory bulb, hippocampus, thalamus and heart. Expressed in the cochlea, organ of Corti. Expression is particularly enriched in the tips of stereocilia of both inner and outer hair cells.
  • 数据库链接：

    KEGG: mmu:26557

    STRING: 10090.ENSMUSP00000026922

    UniGene: Mm.228