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  4. Recombinant Mouse Homeobox protein prophet of Pit-1 (Prop1)

Recombinant Mouse Homeobox protein prophet of Pit-1 (Prop1)

  • 货号：
    CSB-YP018753MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP018753MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP018753MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP018753MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP018753MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Prop1
  • Uniprot No.：
  • 别名：
    Prop1; Prop-1; Homeobox protein prophet of Pit-1; PROP-1; Pituitary-specific homeodomain factor
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-223
  • 氨基酸序列
    MEAQRRSHQE KQTKGHACGR SLPEPRVASG TLISTVDRSS EAYRRLSGTE LGRPKLCPQR GRPHSRRRHR TTFNPAQLEQ LESAFGRNQY PDIWAREGLA QDTGLSEARI QVWFQNRRAK QRKQERSLLQ PIAHLSTATF SGFLPESSAY PYTYGTPPPP APCFPHPYSH SLPSQPSTAA SLALPPQPED WYPTLHPAPT GHLPCPPPPP MFPLSLETPK SWN
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Possibly involved in the ontogenesis of pituitary gonadotropes, as well as somatotropes, lactotropes and caudomedial thyrotropes.
  • 基因功能参考文献：
    1. Genomic profiling reveals that PROP1 binds to genes expressed in epithelial cells like Claudin 23, and to epithelial-mesenchymal transition inducer genes like Zeb2, Notch2 and Gli2. Zeb2 activation appears to be a key step in the epithelial-mesenchymal transition process. PMID: 27351100
    2. SOX2 is a regulatory factor of Prop1 expression PMID: 26640231
    3. Data show that human paired like homeodomain factor 1 (PROP1) can substitute functionally for mouse Prop1. PMID: 26812162
    4. endocochlear potential and KCNJ10 immunostaining in the stria vascularis are indistinguishable from wild type, and no differences in neurofilament or synaptophysin staining are evident in Prop1(df) mutants PMID: 22143287
    5. Several components of the main GH-signaling pathways exhibit enhanced sensitivity to the hormone in liver and muscle of Ames dwarf mice. PMID: 20022531
    6. Studies suggest that TLE1 and TLE3 might also play roles independent of HESX1 by interacting with other transcription factors like PROP1. PMID: 20181723
    7. Tcf4 and Aes influence pituitary growth and development, and place Tcf4 and Tle3 in the genetic hierarchy with Prop1 PMID: 12907761
    8. PROP1 has a role in pituitary gland growth PMID: 15591534
    9. variation in PROP1 expression could affect the growth spurt and the onset of puberty in humans. PMID: 16384867
    10. Prop-1 modulates the synthesis of FSH at the transcriptional level. PMID: 17032749
    11. Functional transcriptional control sequences in the Prop1 gene for spatial expression during pituitary development. PMID: 17557180
    12. These data reveal important overlapping functions of Hes1 and Prop1 in cell differentiation and movement that are critical for pituitary organogenesis. PMID: 18996108

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Paired homeobox family
  • 数据库链接：

    KEGG: mmu:19127

    STRING: 10090.ENSMUSP00000057231

    UniGene: Mm.1386