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  4. Recombinant Mouse Homeobox protein aristaless-like 3 (Alx3)

Recombinant Mouse Homeobox protein aristaless-like 3 (Alx3)

  • 货号：
    CSB-YP001646MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP001646MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP001646MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP001646MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP001646MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Alx3
  • Uniprot No.：
  • 别名：
    Alx3Homeobox protein aristaless-like 3; Proline-rich transcription factor ALX3
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-343
  • 氨基酸序列
    MDPERCAPFS VGPAAGPYAA AGDEAPGPQG TPDAAPHLHP APPRGPRLSR FPACGPLEPY LPEPAKPPAK YLQDLGPGPV LNGGHFYEGS AEAEEKASKA ASFPQLPVDC RGGPRDGPSN VQASPGPCLA SLSVPLSPGL PDSMELAKTK SKKRRNRTTF STFQLEELEK VFQKTHYPDV YAREQLALRT DLTEARVQVW FQNRRAKWRK RERYGKMQEG RNPFTTAYDI SVLPRTDSHP QLQNSLWPSP GSGSPGGPCL MSPEGIPSPC MSPYSHSHGN VAGFMGVPAS PAAHPGIYSI HGFPPALGGH SFEPSPDGDY KSPSLVSLRM KPKEPPGLLN WTT
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcriptional regulator with a possible role in patterning of mesoderm during development.
  • 基因功能参考文献：
    1. Study shows that ALX3 deficiency provides a novel molecular mechanism for developmental defects arising from maternal hyperglycaemia. PMID: 28341857
    2. results indicate that Alx3 expression is enhanced by BMP-2 via the BMP receptors mediated-Smad signaling and that Alx3 is a positive regulator of osteoblast differentiation induced by BMP-2 PMID: 23825702
    3. Glucose-stimulated expression of ALX3 in alpha cells provides a regulatory mechanism for the downregulation of glucagon gene expression by interfering with PAX6-mediated transactivation on the glucagon G1 promoter element. PMID: 26739814
    4. Pdx1, USF1 and USF2 co-ordinately regulate Alx3 gene expression in pancreatic beta-cells. PMID: 25040025
    5. Alx3 promoter activity in mesenchymal and pancreatic cells is regulatd by USF transcription factors and Twist1 PMID: 23181698
    6. ALX3 could be considered as a candidate gene for the etiopathogenesis of diabetes or its complications during embryonic or fetal development is discussed PMID: 21350340
    7. ALX3 participates in the regulation of the expression of essential genes for the function of pancreatic islets, and its deficiency alters the regulation of glucose homeostasis in vivo. PMID: 21104068
    8. Alx3-deficient mice exhibit folic acid-resistant craniofacial midline and neural tube closure defects. PMID: 20534379

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Paired homeobox family
  • 组织特异性：
    Predominantly in neural crest-derived mesenchyme and in lateral plate mesoderm. Prominent expression in frontonasal head mesenchyme and in the first and second pharyngeal arches and some of their derivatives. High expression is also seen in the tail and i
  • 数据库链接：

    KEGG: mmu:11694

    STRING: 10090.ENSMUSP00000014747

    UniGene: Mm.10112