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  4. Recombinant Mouse Homeobox protein TGIF1 (Tgif1)

Recombinant Mouse Homeobox protein TGIF1 (Tgif1)

  • 货号：
    CSB-YP304890MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP304890MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP304890MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP304890MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP304890MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Tgif1; Tgif; Homeobox protein TGIF1; 5'-TG-3'-interacting factor 1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-272
  • 氨基酸序列
    MKSKKGLVAA SGSDSEDEDS MDSPLDLSSS AASGKRRRRG NLPKESVQIL RDWLYEHRYN AYPSEQEKAL LSQQTHLSTL QVCNWFINAR RRLLPDMLRK DGKDPNQFTI SRRGAKISEA SSIEAAMGIK NFMPTLEESP FHSCVVGPNP TLGRPVSPKP PSPGSILARP SVICHTTVTA LKDGPFSLCQ PIGVGQSTDV PQIAPSNFTD TSLVYPEDTC KSGPSPNPQS GLFNTPPPTP PDLNQDFSGF QLLVDVALKR AAEMELQAKL TA
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII-RXRE). Inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. May participate in the transmission of nuclear signals during development and in the adult, as illustrated by the down-modulation of the RXR alpha activities.
  • 基因功能参考文献：
    1. Proteomic analyses show that HOXA1 physically interacts on chromatin with PBX, MEIS, and PREP family members, but not with TGIF, suggesting that TGIF may have an independent input into HOXA1-bound regions.complex cross-regulatory network of HOXA1 and TALE proteins. This study provides new insight into a regulatory network involving combinatorial interactions between HOXA1 and TALE proteins PMID: 28784834
    2. Tgifs regulate ciliogenesis and suggests that Evi5l mediates at least part of this effect. PMID: 27956704
    3. loss of Tgif1 causes axial patterning defects that are enhanced by mutations in Tgif2 PMID: 27187787
    4. Tgif2 participates in photoreceptor cell differentiation in the early stages of retinal development and regulates proper subretinal localization of the cone photoreceptors. PMID: 27639517
    5. Tgif1 suppresses stem cell self-renewal. PMID: 24100014
    6. The identification and characterization of the Tgif mutant supports the role of TGFbeta signalling in the development of chronic OM. PMID: 23459932
    7. Tgif1 mutation in mouse contributes to Holoprosencephaly pathogenesis due to disruption of the Shh pathway PMID: 22383895
    8. TGIF1 plays a role in TNF-alpha- and radiation-induced inflammation and it could be a target in limiting this event in the vascular compartment PMID: 22995913
    9. TGF-beta/Smad co-repressor TGIF1 plays a role in radiation-induced normal tissue damage by a Smad-independent mechanism. PMID: 22567107
    10. Data suggest that in the absence of Tgif1, a persistent increase in TGFbeta responsive transcription and a reduced ability to deal with hyperoxic stress result in premature senescence in primary MEFs. PMID: 22514746
    11. Tgif1 can regulate nuclear receptor complexes, in addition to those containing retinoic acid receptors, but also indicates that there is some specificity to which NR target genes are repressed by Tgif1. PMID: 20506222
    12. Data show that loss-of-function mutations in both Tgif1 and Tgif2 result in a failure of gastrulation. PMID: 20040491
    13. Targeted disruption of Tgif in mice did not induce discernible derangements in forebrain, which point to a possible functional redundancy of Tgif, potentially provided by the closely related Tgif2. PMID: 15831469
    14. loss of TGIF function is compensated by other TGF-beta antagonists such as c-Ski and SnoN during vertebrate anterior neural development PMID: 16284942
    15. TGIF acts as a transcriptional corepressor, which regulates developmental signaling by retinoic acid, and raises the possibility that TGIF may repress other RXR-dependent transcriptional responses. PMID: 16428452
    16. Developmental control of proliferation by Tgif may play a role in the pathogenesis of Holoprosencephaly. PMID: 16705179
    17. Deletion of the third exon of Tgif gene resulted in a defined spectrum of brain developmental defects, and serve as a useful model to unravel the genetic complexity implicated in the pathogenesis of holoprosencephaly. PMID: 17082251
    18. Forced expression of exogenous TGIF repressed both endogenous and overexpressed Smad2/3-mediated promoter activity in 3T3-L1 PMID: 18310014
    19. TGIF is essential for EGF-mediated downregulation of tropoelastin expression PMID: 18441095
    20. Tgif functions in the normal development of the placenta, and suggest a role for maternal factors in regulating the morphogenesis of embryonically-derived placental tissues. PMID: 18508043

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    TALE/TGIF homeobox family
  • 数据库链接：

    KEGG: mmu:21815

    STRING: 10090.ENSMUSP00000130930

    UniGene: Mm.101034