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  4. Recombinant Mouse Homeobox protein Hox-C8 (Hoxc8)

Recombinant Mouse Homeobox protein Hox-C8 (Hoxc8)

  • 中文名称：
    小鼠Hoxc8重组蛋白
  • 货号：
    CSB-YP010678MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Hoxc8重组蛋白
  • 货号：
    CSB-EP010678MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Hoxc8重组蛋白
  • 货号：
    CSB-EP010678MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Hoxc8重组蛋白
  • 货号：
    CSB-BP010678MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Hoxc8重组蛋白
  • 货号：
    CSB-MP010678MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Hoxc8
  • Uniprot No.：
  • 别名：
    Hoxc8; Hox-3.1; Hoxc-8Homeobox protein Hox-C8; Homeobox protein Hox-3.1; Homeobox protein M31
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-242
  • 氨基酸序列
    MSSYFVNPLF SKYKGGESLE PAYYDCRFPQ SVGRSHALVY GPGGSAPGFQ HASHHVQDFF HHGTSGISNS GYQQNPCSLS CHGDASKFYG YEALPRQSLY GAQQEASVVQ YPDCKSSANT NSSEGQGHLN QNSSPSLMFP WMRPHAPGRR SGRQTYSRYQ TLELEKEFLF NPYLTRKRRI EVSHALGLTE RQVKIWFQNR RMKWKKENNK DKLPGARDEE KVEEEGNEEE EKEEEEKEEN KD
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
  • 基因功能参考文献：
    1. Hoxc8 downregulates Mgl1 tumor suppressor gene expression and reduces its concomitant function on cell adhesion. PMID: 21773674
    2. Data provide the basis for future studies in pathogenesis of cartilage defects in Hoxc8- and Hoxd4-transgenic mice. PMID: 20126390
    3. Hoxc8, when over-expressed in C3H10T1/2 or C2C12 cells, suppressed basal Smad6 promoter activity and its mRNA expression PMID: 20016939
    4. Hoxc8 regulation is essential for osteoblast differentiation. PMID: 19214787
    5. Pcna is a direct downstream target of Hoxc8. PMID: 20097160
    6. interaction with smad1 stimulates bone development PMID: 14672939
    7. remodeling of Hox regulatory elements in different species has played a significant role in generating morphological diversity PMID: 14673077
    8. In mice, Hoxc8 has a role in the formation of the vertebrae and ribs and may be involved in the differentiation of the kidney. PMID: 15674821
    9. OPN is a direct transcriptional target of Hoxc8 PMID: 15699330
    10. Raldh2L-/- phenotype relies in part on the deregulation of Hoxc8, which in turn regulates the RA receptor RARbeta PMID: 15753214
    11. the genes described here should aid in the understanding of global regulatory networks of Hox genes and to provide valuable insight into the molecular basis of Hoxc8 in development and carcinogenesis PMID: 16793922
    12. Precise temporal expression of Hoxc8 is important for determining the correct identity of the vertebral column in early embryos. PMID: 16831908
    13. These studies document a functional role for Ap2delta in recruiting histone methyltransferases to specific gene targets, such as Hoxc8. PMID: 18495928
    14. These results indicate that the 16 amino acid third helix is the key element responsible for the membrane transduction activity of Hoxc8 proteins. PMID: 18835255
    15. Our results provide evidence for a role for Hoxc8 in controlling cell cycle progression PMID: 19071237

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Antp homeobox family
  • 数据库链接：

    KEGG: mmu:15426

    STRING: 10090.ENSMUSP00000001703

    UniGene: Mm.6167