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  4. Recombinant Mouse Homeobox protein CDX-1 (Cdx1)

Recombinant Mouse Homeobox protein CDX-1 (Cdx1)

  • 货号：
    CSB-YP005127MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP005127MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP005127MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP005127MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP005127MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Cdx1
  • Uniprot No.：
  • 别名：
    Cdx1; Cdx-1Homeobox protein CDX-1; Caudal-type homeobox protein 1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-268
  • 氨基酸序列
    MYVGYVLDKD SPVYPGPARP SSLGLGPPTY APPGPAPAPP QYPDFAGYTH VEPAPAPPPT WAAPFPAPKD DWAAAYGPGP TASAASPAPL AFGPPPDFSP VPAPPGPGPG ILAQSLGAPG APSSPGAPRR TPYEWMRRSV AAAGGGGSGK TRTKDKYRVV YTDHQRLELE KEFHYSRYIT IRRKSELAAN LGLTERQVKI WFQNRRAKER KVNKKKQQQQ QPLPPTQLPL PLDGTPTPSG PPLGSLCPTN AGLLGTPSPV PVKEEFLP
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays a role in transcriptional regulation. Involved in activated KRAS-mediated transcriptional activation of PRKD1 in colorectal cancer (CRC) cells. Binds to the PRKD1 promoter in colorectal cancer (CRC) cells. Could play a role in the terminal differentiation of the intestine. Binds preferentially to methylated DNA.
  • 基因功能参考文献：
    1. Cdx1-Cdx2 double null mutants exhibited loss of primitive erythroblasts, aberrant vascular remodelling of the yolk sac and a block in hematopoietic differentiation from yolk sac-derived cells in culture. PMID: 28065741
    2. transient expression of CDX1 promotes epicardial EMT, whereas subsequent down-regulation of CDX1 after 11.5 dpc in mice is necessary for further subepicardial invasion of EPDCs and contribution to coronary vascular endothelium or smooth muscle cells. PMID: 25068460
    3. These findings underscore previously unrecognized roles for Cdx members in intestinal tumorigenesis PMID: 25320087
    4. we found that relative to Cdx1, Cdx2 was significantly less potent at effecting a transcriptional response from the Cdx1 promoter, a known Cdx target gene. PMID: 23382958
    5. study is the first example of Cdx-Hox protein interactions and suggests that such complexes may modulate Hox and/or Cdx function PMID: 23121490
    6. Cdx1 regulation on HoxC8 expression and suggest the possibility that the temporal changes in Cdx activity levels during gastrulation, combined with differential DNA binding affinity, might play a role in the establishment of Hox sequential activation. PMID: 22426122
    7. The findings suggested that Cdx2 is essential for differentiation of the small intestinal epithelium, and that both Cdx1 and Cdx2 contribute to homeostasis of the colon. PMID: 22285812
    8. Cdx members operate upstream of Dll1 to convey different functions in both somitogenesis and Goblet cell differentiation. PMID: 22015720
    9. Data suggest that cdx proteins affect cardiogenesis by regulating the formation of cardiogenic mesoderm. PMID: 21466798
    10. Data present evidence that Cdx1 is also a developmental regulator of the female urogenital system. PMID: 21425084
    11. Cdx1 expression is less prominent than that of Cdx2 in mature villus cells but in the absence of Cdx2, Cdx1 compensates for its absence. PMID: 21402776
    12. These findings illustrate a novel and pivotal role for Cdx function upstream of Ptk7 and neural tube closure in vertebrates. PMID: 21350009
    13. Findings identify Mafb as one of the earliest direct targets of Cdx1 and show that Cdx1 plays a direct role in early hindbrain patterning. PMID: 21098558
    14. CDX1 and CDX2 bind the promoter region of SLC5A8 and up-regulate its expression in cultured cells and in colonic epithelium. PMID: 19900445
    15. Cdx1 and Cdx2 have overlapping functions in anteroposterior patterning and posterior axis elongation. PMID: 11959827
    16. CDX1 is downregulated after promoter methylation in colorectal tumor cell lines PMID: 12124393
    17. Cdx1 expression in developing mouse is regulated through the caudalizing Wnt/beta-catenin and RA activities PMID: 12242722
    18. Cdx1 has a role in apoB mrna editing, which is part of the cytodifferentiation function of the small intestine PMID: 12493769
    19. pivotal role for retinoid signalling in governing a subset of expression of Cdx1 crucial for normal vertebral patterning PMID: 14660544
    20. Cdx1 or Cdx2 expression is sufficient to induce E-cadherin-dependent adhesion of COLO 205 cells associated with polarization and cell-cell membrane compaction, as well as induction of differentiated gene-expression pattern. PMID: 14977637
    21. Cdx1 and Cdx2 have roles in enhancer activation in postnatal duodenum PMID: 15677472
    22. These findings suggest a model by which COUP-TF expression is induced by retinoic acid in the trunk region as a negative feedback mechanism to restrict Cdx1 expression to the caudal embryo. PMID: 15677473
    23. demonstrate a unique pattern of regulation for small inducible chemokine 25 and suggest a role for Cdx proteins in regulating CCL25 transcription PMID: 16517733
    24. study concludes that Cdx expression in Colo 205 cells induces E-cadherin-dependent cell-cell adhesion by reducing beta- and p120-catenin tyrosine phosphorylation PMID: 17463179
    25. Wnt signaling is a key mediator of Cdx1 expression in vivo. PMID: 17537796
    26. stromal cell and colony assay cultures of EB-derived hematopoietic progenitors subjected to ectopic expression of Cdx genes, Cdx4 enhances, whereas Cdx1 and Cdx2 inhibit hematopoietic activity, probably by blocking progenitor differentiation PMID: 18252864
    27. Cdx1 is dispensable for intestinal development and that its overexpression could increase malignancy in early stages of tumourigenesis. PMID: 18372917
    28. These results reveal an essential and partially redundant role for Cdx1, Cdx2, and Cdx4 genes during embryonic hematopoiesis in the mouse. PMID: 18511567
    29. Transgenic embryos show Cdx transcription at 8.5 to 8.7 days within normal spatial domains for Cdx expression (primitive streak/tailbud), yet, overall, they contain elevated levels of Cdx proteins PMID: 18579683
    30. Cdx1::Cre allele for gene analysis in the extraembryonic ectoderm and the three germ layers of mice at mid-gastrulation. PMID: 19241391
    31. Cdx1 and Cdx2 are functionally equivalent in vertebral patterning PMID: 19328777
    32. Transgenic Cdx2 induced endogenous Cdx1 through the binding of Cdx2 to the unmethylated Cdx1 promoter region in the intestinal metaplasia of the Cdx2-transgenic mouse stomach. PMID: 19725873

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Caudal homeobox family
  • 组织特异性：
    Intestinal epithelium.
  • 数据库链接：

    KEGG: mmu:12590

    STRING: 10090.ENSMUSP00000025521

    UniGene: Mm.144448