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  4. Recombinant Mouse Histone H1oo (H1foo)

Recombinant Mouse Histone H1oo (H1foo)

  • 中文名称：
    小鼠H1foo重组蛋白
  • 货号：
    CSB-YP851864MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠H1foo重组蛋白
  • 货号：
    CSB-EP851864MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠H1foo重组蛋白
  • 货号：
    CSB-EP851864MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠H1foo重组蛋白
  • 货号：
    CSB-BP851864MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠H1foo重组蛋白
  • 货号：
    CSB-MP851864MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    H1foo
  • Uniprot No.：
  • 别名：
    H1foo; H1oo; Histone H1oo; Oocyte-specific histone H1; Oocyte-specific linker histone H1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-304
  • 氨基酸序列
    MAPGSVSSVS SSSFPSRDTS PSGSCGLPGA DKPGPSCRRI QAGQRNPTML HMVLEALKAR EARQGTSVVA IKVYIQHKYP TVDTTRFKYL LKQALETGVR RGLLTRPAHS KAKGATGSFK LVPKPKTKKA CAPKAGRGAA GAKETGSKKS GLLKKDQVGK ATMEKGQKRR AYPCKAATLE MAPKKAKAKP KEVRKAPLKQ DKAAGAPLTA NGGQKVKRSG SRQEANAHGK TKGEKSKPLA SKVQNSVASL AKRKMADMAH TVTVVQGAET VQETKVPTPS QDIGHKVQPI PRVRKAKTPE NTQA
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    May play a key role in the control of gene expression during oogenesis and early embryogenesis, presumably through the perturbation of chromatin structure. Essential for meiotic maturation of germinal vesicle-stage oocytes. The somatic type linker histone H1c is rapidly replaced by H1oo in a donor nucleus transplanted into an oocyte. The greater mobility of H1oo as compared to H1c may contribute to this rapid replacement and increased instability of the embryonic chromatin structure. The rapid replacement of H1c with H1oo may play an important role in nuclear remodeling.
  • 基因功能参考文献：
    1. H1foo contributes to the generation of higher-quality induced pluripotent stem cells. PMID: 27237376
    2. H1foo has an impact on the genome-wide, locus-specific epigenetic status. PMID: 22868987
    3. may play a key role in the control of gene expression during oogenesis and early embryogenesis, presumably through the perturbation of chromatin structure PMID: 12770723
    4. The expression of the oocytic H1FOO transcript and protein proved temporally coupled to the recruitment of resting primordial follicles into a developing primary follicular cohort and thus to the critical transition marking the onset of oocytic growth PMID: 15371275
    5. that H1foo is essential for maturation of germinal vesicle-stage oocytes PMID: 17519519
    6. The unmethylated status was continuously observed throughout oogenesis, in mature oocytes, and after fertilization, in E3.5 blastocysts. There is a continuously unmethylated circuit at the H1foo locus in the female germline. PMID: 18184919
    7. Promoter activities of three mouse maternal genes (H1oo, Npm2, and Zar1) in oocytes and pre-implantation embryos, and examined the promoters and to obttain the best promoter for oocytte gene expression. PMID: 18324673

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  • 亚细胞定位：
    Cytoplasm. Nucleus. Chromosome. Note=In the germinal vesicle oocyte, localizes to the condensed chromosomes. In the 1-cell embryo found in condensed maternal metaphase chromatin but not in the sperm head. Following second polar body extrusion, detected in the swollen sperm head as well as in the second polar body. Reduced expression in the nucleus in 2-cell embryo is seen as compared to 1-cell embryo.
  • 蛋白家族：
    Histone H1/H5 family
  • 组织特异性：
    Oocyte-specific.
  • 数据库链接：

    KEGG: mmu:171506

    STRING: 10090.ENSMUSP00000036951

    UniGene: Mm.21899