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  4. Recombinant Mouse High mobility group nucleosome-binding domain-containing protein 5 (Hmgn5)

Recombinant Mouse High mobility group nucleosome-binding domain-containing protein 5 (Hmgn5)

  • 中文名称：
    小鼠Hmgn5重组蛋白
  • 货号：
    CSB-YP864362MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Hmgn5重组蛋白
  • 货号：
    CSB-EP864362MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Hmgn5重组蛋白
  • 货号：
    CSB-EP864362MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Hmgn5重组蛋白
  • 货号：
    CSB-BP864362MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Hmgn5重组蛋白
  • 货号：
    CSB-MP864362MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Hmgn5
  • Uniprot No.：
  • 别名：
    Hmgn5; Garp45; Nsbp1; High mobility group nucleosome-binding domain-containing protein 5; Nucleosome-binding protein 1; Nucleosome-binding protein 45; NBP-45; Protein GARP45
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-406
  • 氨基酸序列
    MPKRKAAGDV SQEPKRRSAR LSAMPVPFTP ELKPKRASTS RKTKTTNVVE ENKDASTIPI PETKPEDVKD ECNMENAENG EAKIMEAPIP KMEAEEVKEQ INEDTEEDGG EKKEAVAAEA KDDELKANIQ DVEKDEDGKE HKDTGEEVED GKIEEEGLNE KPGTAKSEDA EVSKDEEEKG DNEKGEDGKE EGDEKEEEKD DKEGDTGTEK EVKEQNKEAE EDDGKCKEEE NKEVGKEGQP EEDGKEDLHE EVGKEDLHEE DGKEGQPEED GKEIHHEEDG KEGQPEEDGK EYLHEEDGEE GQPKEDQKEG QPEEDGKEDQ PEEDGKEGQC KEDGKEGHHE EGGKEDLHEE DGKEKDGGKE DRKEEGEQEV AVDEGSDENK VEAEEEGAEN KDFKQDGEKE EPLSIV
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Preferentially binds to euchromatin and modulates cellular transcription by counteracting linker histone-mediated chromatin compaction.
  • 基因功能参考文献：
    1. Hmgn5 might act downstream of Hoxa10 to regulate the expression of Cox-2, Vegf and Mmp2. PMID: 27579887
    2. Mice overexpressing HMGN5, either globally or only in the heart, are normal at birth but develop hypertrophic heart with large cardiomyoctyes, deformed nuclei and disrupted lamina, and die of cardiac malfunction. PMID: 25609380
    3. HMGN5 overexpression induces neurite outgrowth. PMID: 25825524
    4. functional loss of HMGN5 leads to changes in transcription of Gpx6 and Hk1 that alter glutathione metabolism. PMID: 24392144
    5. Phenotypic analysis of Hmgn1(tm1/tm1), Hmgn3(tm1/tm1), and Hmgn5(tm1/tm1) mice and their wild type littermates with a battery of standardized tests uncovered variant-specific abnormalities. PMID: 23620591
    6. Downregulation of NSBP1 reduced the cancer growth rate, whereas tumourigenicity was not influenced. PMID: 20531280
    7. NSBP1 is an architectural protein that binds preferentially to euchromatin and modulates the fidelity of the cellular transcription profile by counteracting the chromatin-condensing activity of linker histones. PMID: 19748358

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  • 亚细胞定位：
    Nucleus. Note=Associates with nucleosomes in euchromatin and is largely excluded from constitutive heterochromatin.
  • 蛋白家族：
    HMGN family
  • 组织特异性：
    Expressed in liver, spleen, lung, heart, kidney, muscle and brain (at protein level). Widely expressed with highest levels in submaxillary gland, thymus, kidney and liver and lowest levels in brain, lung, pancreas and eye.
  • 数据库链接：

    KEGG: mmu:50887

    STRING: 10090.ENSMUSP00000033597

    UniGene: Mm.298443