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  4. Recombinant Mouse High affinity immunoglobulin alpha and immunoglobulin mu Fc receptor (Fcamr), partial

Recombinant Mouse High affinity immunoglobulin alpha and immunoglobulin mu Fc receptor (Fcamr), partial

  • 中文名称：
    小鼠Fcamr重组蛋白
  • 货号：
    CSB-YP647196MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Fcamr重组蛋白
  • 货号：
    CSB-EP647196MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Fcamr重组蛋白
  • 货号：
    CSB-EP647196MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Fcamr重组蛋白
  • 货号：
    CSB-BP647196MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Fcamr重组蛋白
  • 货号：
    CSB-MP647196MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    FcamrHigh affinity immunoglobulin alpha and immunoglobulin mu Fc receptor; Fc alpha/mu receptor; mFcamR; CD antigen CD351
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Functions as a receptor for the Fc fragment of IgA and IgM. Binds IgA and IgM with high affinity and mediates their endocytosis. May function in the immune response to microbes mediated by IgA and IgM.
  • 基因功能参考文献：
    1. Serum IgA production against gut-oriented antigens is negatively regulated by Fcalpha/muR on follicular dendritic cells in the F1 mice. PMID: 25282043
    2. These results suggest that Fcalpha/muR enhances, rather than suppresses, autoantibody production. PMID: 24172225
    3. Data suggest that Fcalpha/muR does not form homodimers, but forms heterodimers with an as-yet-unknown molecule with a molecular weight of 60-70 kDa. PMID: 23665380
    4. A significant portion of the effector function of IgM, especially with regard to the enhancement of humoral immune responses and suppression of autoimmunity, is mediated by FcmuR. PMID: 22988094
    5. Mice deficient in Fc alpha/muR have enhanced germinal center formation and affinity maturation and memory induction of IgG3(+) B cells after immunization with T-independent antigens.[Fc alpha/muR] PMID: 19549827
    6. expressed in oligodendrocytes, their precursor cells, and myelin PMID: 12527391

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 组织特异性：
    Expressed in several tissues including thymus, spleen, liver, kidney, small and large intestine, testis and placenta. Expressed by oligodendrocytes, B-cells and macrophages but not granulocytes, T-cells or NK cells (at protein level).
  • 数据库链接：

    KEGG: mmu:64435

    UniGene: Mm.31821