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  4. Recombinant Mouse Hepcidin (Hamp), partial

Recombinant Mouse Hepcidin (Hamp), partial

  • 中文名称：
    小鼠Hamp重组蛋白
  • 货号：
    CSB-YP887650MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Hamp重组蛋白
  • 货号：
    CSB-EP887650MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Hamp重组蛋白
  • 货号：
    CSB-EP887650MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Hamp重组蛋白
  • 货号：
    CSB-BP887650MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Hamp重组蛋白
  • 货号：
    CSB-MP887650MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Hamp
  • Uniprot No.：
  • 别名：
    Hamp; Hamp1; Hepc; Hepc1; Hepcidin
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 表达区域：
    59-83
  • 氨基酸序列
    DT NFPICIFCCK CCNNSQCGIC CKT
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Liver-produced hormone that constitutes the main circulating regulator of iron absorption and distribution across tissues. Acts by promoting endocytosis and degradation of ferroportin, leading to the retention of iron in iron-exporting cells and decreased flow of iron into plasma. Controls the major flows of iron into plasma: absorption of dietary iron in the intestine, recycling of iron by macrophages, which phagocytose old erythrocytes and other cells, and mobilization of stored iron from hepatocytes.
  • 基因功能参考文献：
    1. results indicate that a 0.25% carbonyl iron diet is sufficient to induce maximal hepatic hepcidin response. Importantly these results also demonstrate that in a chronic setting of iron administration, the amount of excess hepatic iron may not further influence hepcidin regulation and that expression of hepcidin plateaus at lower hepatic iron levels. These studies provide further insights into the regulation of this import PMID: 29752985
    2. Increased serum hepcidin contributes to the anemia of chronic kidney disease in a murine model. PMID: 27884972
    3. bone marrow transplantation between wild-type and TLR4 knockout mice revealed that hepatic TLR4-dependent hepcidin expression was comparable to macrophage TLR4-dependent hepcidin expression induced by LPS PMID: 29217822
    4. Hepc decreases in Cyp1b1-/- and gestational vitamin A deficiency mice resulted in stellate activation and lipogenesis suppression. PMID: 28583802
    5. data indicate that unlike with many other infections, hepcidin is decreased following M.tb infection, and show that hepcidin ablation does not influence M.tb growth in vivo PMID: 29324800
    6. Hepcidin expression involves epigenetic regulation by histone deacetylase 3. PMID: 28864822
    7. Serum hepcidin levels were measured by competitive ELISA in wild-type and Inhbb-/- mice at baseline and 4 hours after LPS challenge. Although Smad1/5/8 signaling is not activated by inflammatory stimuli in the absence of activin B, this has no impact on the induction of hepcidin expression. PMID: 27903526
    8. hepcidin mRNA upregulation depends on M1 macrophage polarization PMID: 27667162
    9. Our data provide evidence that the interplay of these two hormones could help improve the understanding of the pathogenesis of atherosclerosis and NAFLD. PMID: 29158088
    10. downregulation of hepcidin by siRNA increased iron uptake in bone and liver, which aggravated unloading-induced bone loss. PMID: 27686598
    11. The s generated mice with cardiomyocyte-specific deletion of hepcidin, or knock-in of hepcidin-resistant ferroportin. They find that while both models maintain normal systemic iron homeostasis, the mice nonetheless develop fatal contractile and metabolic dysfunction as a consequence of cardiomyocyte iron deficiency. PMID: 27897970
    12. Acute tacrolimus treatment transiently increases hepcidin in wild-type mice. FKBP12 preferentially targets the BMP receptor ALK2. ALK2 mutants defective in binding FKBP12 increase hepcidin expression in a ligand-independent manner, through BMP-SMAD signaling. PMID: 28864813
    13. Hamp1 mRNA and plasma hepcidin levels are not good predictors of tissue iron levels, at least in males PMID: 28798083
    14. The lack of effect of erythropoietin on hepcidin expression in mask mice can not be explained by changes in erythroferrone synthesis, as splenic erythroferrone content increased after erythropoietin administration in both C57BL/6 and mask mice. PMID: 29073189
    15. these results characterise a new model of rapidly inducible hepcidin disruption, and demonstrate the critical contribution of hepcidin to the hypoferraemia of inflammation PMID: 27423740
    16. Hepatic gene expression of hepcidin is regulated in beta-thalassemia by ATOH8. PMID: 28405918
    17. Endogenous hepcidin and its agonist mediate resistance to selected infections by clearing non-transferrin-bound iron. PMID: 28465342
    18. the relationship between erythropoiesis and the candidate erythroid regulators, was examined. PMID: 28135344
    19. Smad1 and Smad5 have overlapping functions to govern hepcidin transcription. Moreover, erythropoietin and erythroferrone target Smad1/5 signaling and require Smad1/5 to suppress hepcidin expression. PMID: 28438754
    20. Genetic inactivation of hepatic angiocrine Bmp2 signaling in Stab2-Cre mice caused massive iron overload in the liver and increased serum iron levels and iron deposition in several organs similar to classic hereditary hemochromatosis; these changes were mediated by decreased hepatic expression of hepcidin, a key regulator of iron homeostasis. PMID: 27903529
    21. These studies indicate that drug-like minihepcidins have a potential as future therapeutics for untransfused beta-thalassemia and polycythemia vera. PMID: 27154187
    22. hepcidin induction by endoplasmic reticulum stress involves the central SMAD1/5/8 pathway PMID: 27483343
    23. Increased hepcidin in transferrin-treated thalassemic mice correlates with increased liver BMP2 expression and decreased hepatocyte ERK activation. PMID: 26635037
    24. The combined data presented here highlighted a crucial role of ERFE in regulating hepcidin expression and systematic iron homeostasis under phenylhydrazine-induced hemolytic anemia. PMID: 27067488
    25. The results suggest that physiologic hepcidin levels are insufficient to alter Fpn levels within the retinal pigment epithelium and Muller cells, but may limit iron transport into the retina from vascular endothelial cells. PMID: 26506980
    26. In TNF(DeltaARE/+) and IL-10(-/-)-mice hepatic hepcidin expression and protein content was significantly lower than in corresponding wild-types. PMID: 26302924
    27. In Angiotensin II treated mice, duodenal divalent metal transporter-1 and ferroportin expression levels were increased and hepatic hepcidin mRNA expression and serum hepcidin concentration were reduced. PMID: 25096756
    28. results clarify how commensal bacteria affect hepcidin expression and reveal a novel connection between IL-1beta and activation of BMP signaling. PMID: 26515063
    29. Activation of TLR4 signaling and NF-small ka, CyrillicB are involved in the suppression of hepcidin gene transcription by alcohol in the presence of inflammation in the liver. PMID: 25232250
    30. Study describes extensive blood vessel damage in Alzheimer's disease brain and a reduction in hepcidin and ferroportin levels PMID: 24252754
    31. Hepatic hepcidin plays an important role in sepsis through regulation of iron metabolism PMID: 25264597
    32. Hepc1(-/-) mice had a phenotype of low bone mass and alteration of the bone microarchitecture, most likely caused by a decreased osteoblastic activity PMID: 24652331
    33. Hepcidin mRNA expression was increased in the D-galactose (D-gal) group, decreased in the caloric restriction (CR) group, and was basically unchanged in the D-gal-CR group. PMID: 24044515
    34. results provide evidence that HFE induces hepcidin expression via the BMP pathway: HFE interacts with ALK3 to stabilize ALK3 protein and increase ALK3 expression at the cell surface. PMID: 24904118
    35. Data suggest that hepcidin-1 expression is up-regulated in obesity in visceral/subcutaneous adipose tissue (but down-regulated in liver); hepcidin may play local roles in modulating both iron metabolism and inflammation in adipose tissue. PMID: 24418880
    36. Hepcidin expression is upregulated in interleukin (IL)-10-deficient mice and downregulated in wild-type mice with dextran sulfate sodium-induced colitis. PMID: 24973448
    37. this study shows that the liver-specific KO mice fully recapitulate the severe iron overload phenotype observed in the total KO mice, with increased plasma iron and massive parenchymal iron accumulation. PMID: 24646470
    38. Results indicate a negative role of hepcidin in modulating liver regeneration. PMID: 24123375
    39. The Hamp1 and interleukin-6 knock out genotype resulted in improved erythropoiesis in aged mice. PMID: 23996485
    40. Hepcidin deficiency resulted in a marked reduction of bone load-bearing capacity likely through enhancing bone resorption, suggesting a direct correlation between hepcidin deficiency and bone loss. PMID: 24561287
    41. Hepcidin regulates intrarenal iron handling at the distal nephron. PMID: 23615502
    42. Data suggest that Hamp1 expression in liver can be regulated by dietary factors (here, down-regulated by a hematinic dietary supplement, black soyabean seed coat extract). PMID: 24387766
    43. Identify a link between glucose and iron homeostasis, showing that hepcidin is a gluconeogenic sensor in mice during starvation. PMID: 24361124
    44. Direct transcriptional suppression of hepcidin gene (HAMP) expression mediated by 1,25-dihydroxyvitamin D binding to the vitamin D receptor causes decrease in hepcidin mRNA levels PMID: 24204002
    45. The Brucella abortus model shows multifactorial pathogenesis of inflammatory anemia including iron restriction from increased hepcidin, transient suppression of erythropoiesis, and shortened erythrocyte lifespan. PMID: 24357728
    46. Knockout mice exhibited different patterns in the development and resolution of anemia, supporting the notion that interleukin 6 and hepcidin play distinct roles in modulating erythropoiesis in anemia of inflammation. PMID: 24357729
    47. Exogenous mouse IgG1 Fc fused to the N terminus of mouse IL-22 induced hepcidin production. Ab-mediated blockade of hepcidin partially reversed the effects on iron biology caused by IL-22R stimulation. PMID: 23836059
    48. Iron overload increased pro-hepcidin that remained high in hypoxia. PMID: 23656253
    49. A model is proposed that suggests that unlike proteases, which are irreversibly bound to activated alpha2M, hepcidin remains labile and available to down-regulate Fpn1. PMID: 23846698
    50. role of hepcidin in the setting of hypoferremia during acute inflammation PMID: 23637785

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Hepcidin family
  • 组织特异性：
    Highly expressed in the liver and to a much lesser extent in the heart. Secreted in blood.
  • 数据库链接：

    KEGG: mmu:84506

    STRING: 10090.ENSMUSP00000055404

    UniGene: Mm.439939