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  4. Recombinant Mouse Hematopoietic prostaglandin D synthase (Hpgds)

Recombinant Mouse Hematopoietic prostaglandin D synthase (Hpgds)

  • 中文名称：
    小鼠Hpgds重组蛋白
  • 货号：
    CSB-YP867472MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Hpgds重组蛋白
  • 货号：
    CSB-EP867472MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Hpgds重组蛋白
  • 货号：
    CSB-EP867472MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Hpgds重组蛋白
  • 货号：
    CSB-BP867472MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Hpgds重组蛋白
  • 货号：
    CSB-MP867472MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Hpgds
  • Uniprot No.：
  • 别名：
    Hpgds; Gsts; Pgds; Ptgds2Hematopoietic prostaglandin D synthase; H-PGDS; EC 5.3.99.2; GST class-sigma; Glutathione S-transferase; EC 2.5.1.18; Glutathione-dependent PGD synthase; Glutathione-requiring prostaglandin D synthase; Prostaglandin-H2 D-isomerase
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-199
  • 氨基酸序列
    MPNYKLLYFN MRGRAEIIRY IFAYLDIKYE DHRIEQADWP KIKPTLPFGK IPVLEVEGLT IHQSLAIARY LTKNTDLAGK TALEQCQADA VVDTLDDFMS LFPWAEKDQD LKERMFNELL THQAPRLLKD LDTYLGDKEW FIGNYVTWAD FYWDICSTTL LVLKPGLLDI YPKLVSLRNK VQAIPAISAW ILKRPQTKL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Bifunctional enzyme which catalyzes both the conversion of PGH2 to PGD2, a prostaglandin involved in smooth muscle contraction/relaxation and a potent inhibitor of platelet aggregation, and the conjugation of glutathione with a wide range of aryl halides and organic isothiocyanates. Also exhibits low glutathione-peroxidase activity.
  • 基因功能参考文献：
    1. H-PGDS deficiency accelerates the production of SDF-1alpha and the activity of MMP-9 in the antigen-stimulated intestine. SDF-1alpha receptor blockade or MMP-9 inhibition relieves the exacerbated mast cell hyperplasia and manifestations observed in H-PGDS(-/-). PMID: 26159556
    2. HPGDS may play a role in the regulation of inflammation and epithelial cell health within the oviduct. PMID: 22374975
    3. These data suggest that PGD(2) generated via HPGDS has detrimental effects after spinal cord injury and that blocking the activity of this enzyme can be beneficial. PMID: 21294159
    4. hPGD(2)S-derived cyclopentenone prostaglandins may protect against inflammatory diseases, where T lymphocytes play a pathogenic role, as in rheumatoid arthritis, atopic eczema, and chronic rejection PMID: 16547141
    5. Our results demonstrated that the neuroprotective effects of HPGDS in our model are mediated by suppression of activation and infiltration of inflammatory cells. PMID: 19531375

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  • 亚细胞定位：
    Cytoplasm.
  • 蛋白家族：
    GST superfamily, Sigma family
  • 组织特异性：
    Expressed in skin and oviduct.
  • 数据库链接：

    KEGG: mmu:54486

    STRING: 10090.ENSMUSP00000031982

    UniGene: Mm.410688