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  4. Recombinant Mouse Hematopoietic progenitor cell antigen CD34 (Cd34), partial

Recombinant Mouse Hematopoietic progenitor cell antigen CD34 (Cd34), partial

  • 货号：
    CSB-YP737351MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP737351MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP737351MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP737351MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP737351MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Cd34Hematopoietic progenitor cell antigen CD34; CD antigen CD34
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Possible adhesion molecule with a role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. Could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. Presents carbohydrate ligands to selectins.
  • 基因功能参考文献：
    1. These results provide evidence that CD34 is required for AHR and airway reactivity maintenance in the early days after an inflammatory episode in asthma. PMID: 28850257
    2. data suggest that CD34 plays an essential role in maintaining vascular integrity in the lung in response to chemical- and infection-induced tissue damage. PMID: 28683207
    3. sca-1 antibody reduces both CD34+/c-kit+ progenitor cell surge and vascular restenosis after endoluminal vascular injury in a murine model. PMID: 27666446
    4. Aging induces loss of stemness with concomitant gain of myogenic properties of a pure population of CD34+/CD45- muscle derived stem cells. PMID: 26655331
    5. Stem cell factor is essential for preserving reconstitution capacity of ex vivo expanded cord blood CD34(+) cells in Immunocompromised mice. PMID: 25899394
    6. combinatorial expression of CD105 and CD34 receptors controls bone morphogenetic protein responsiveness in adipose-derived stem cells PMID: 25728702
    7. Our results suggest that CD34+ cells may represent the adipose-derived mesenchymal stem cells which possess stronger multiple differentiation potential during reconstituted skin development PMID: 23404453
    8. Data suggest that CD34 may be a specific marker for functionality, with some specificity for insulin. PMID: 23973805
    9. murine in vitro expanded bone marrow-derived murine mesenchymal stem cells can transform into CD34 expressing cells that induce sarcoma formation in vivo. PMID: 22771324
    10. Blood-borne CD34(+) endothelial progenitor cells, characterized by active cell division and an amplified transcriptional signature, transition into resident endothelial cells during compensatory lung growth. PMID: 21921238
    11. CD34 is necessary for efficient muscle regeneration in adult mice. PMID: 21997891
    12. We conclude that CD34 is expressed by mucosal Dendritic Cells and plays an important role in their trafficking through the lung and to the lymph nodes. PMID: 21642249
    13. A novel role for CD34 in both early and late tumor growth, is shown. PMID: 21494591
    14. study demonstrates a novel role for CD34 in enhancing migration of inflammatory cells and thereby exacerbating host-mediated immunopathology in the intestine of S. Typhimurium-infected mice PMID: 20497179
    15. Data show that high levels of KRT15 expression correlated with a stem cell phenotype and found that KRT15hiITGA6hi stem cells were preserved in bald scalp, while distinct populations of CD200hiITGA6hi and CD34hi cells were markedly diminished. PMID: 21206086
    16. CD133, CD15/SSEA-1, and CD34 do not resume tumor-initiating properties of long-term cultured malignant glio-neuronal stem cells PMID: 20181261
    17. CD34 was expressed on colon-infiltrating eosinophils and played a role in eosinophil migration. Further, our findings suggest CD34 is required for efficient eosinophil migration, but not proliferation or expansion in the development of ulcerative colitis. PMID: 20696776
    18. Data show that the majority of chondrocyte-like cells are of bone marrow origin, whereas CD34(+)/CD13(+) myeloid precursors appear to infiltrate the plaque actively and transdifferentiate into chondrocyte-like cells in the progression of atherosclerosis. PMID: 20489139
    19. Cd34-deficient mice are hypersensitive to autoimmune arthritis, exhibiting an increased vascular leakage at onset of disease which correlates with a subsequent increase in disease severity. PMID: 20038636
    20. Relationship between CD34 expression and CD4 and Mac-1 expression by hematpoietic stem cells and their long-term reconstitution capability. PMID: 11937272
    21. Differential regulation of the human and murine CD34 genes in hematopoietic stem cells PMID: 11983914
    22. Identification and utilization of muscle progenitor cells based on CD34 expression led to enhanced muscle regeneration, with CD34 progenitors exhibiting significant improvements in dystrophin restoration. PMID: 12376567
    23. a specific marker of mature murine mast cells PMID: 12384153
    24. CD34(+) cells lack expression of skeletal-, cardiac-, or hematopoietic-specific mRNA transcripts PMID: 12703978
    25. mobilized CD34+ cells do not reside in G0, but in early G1 phase, and did not cross the restriction point into late G1 phase PMID: 15941859
    26. Data indicate that CD34 expression in mature blood cells has a suppressive effect on cellular trafficking to hematopoietic stroma organs, thereby supporting a modulating role of the CD34 molecule in cytoadhesion. PMID: 17521240
    27. transcriptional analysis of CD34-enriched mouse keratinocyte stem cells PMID: 17581618
    28. determined reconstitution capacity of CD34(-)/CD45(-) (Sk-DN) cells as a candidate somatic stem cell source for transplantation PMID: 17762938
    29. elastic laminae stimulate the formation of smooth muscle alpha actin filaments in CD34+ bone marrow cells and SHP-1 mediates the stimulatory effect of elastic laminae PMID: 18258420
    30. Data suggest that dipeptide gamma-d-Glu-d-Trp (thymodepressin) suppresses mobilization/migration of CD34+ hemopoietic precursor cells from the bone marrow to the peripheral blood of tumor-bearing mice. PMID: 19145362
    31. CD34 is a blocker of cell adhesion. Its expression makes mast cells more mobile and invasive. PMID: 15664158
    32. CD34 is a marker of mature mast cells and their precursors. It is difficult to separate mast cells from hematopoietic stem cells based on surface marker expression and growth factor requirements. PMID: 12384153

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  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    CD34 family
  • 组织特异性：
    Expressed in the kidney where it is detected in the thin limb of Henle's loop (at protein level). Highly expressed in hematopoietic progenitor cell lines, brain and testis, and moderately in the thymus, spleen, and bone marrow, but not in adult liver.
  • 数据库链接：

    KEGG: mmu:12490

    STRING: 10090.ENSMUSP00000016638

    UniGene: Mm.29798