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  4. Recombinant Mouse Hematopoietic SH2 domain-containing protein (Hsh2d)

Recombinant Mouse Hematopoietic SH2 domain-containing protein (Hsh2d)

  • 中文名称：
    小鼠Hsh2d重组蛋白
  • 货号：
    CSB-YP744289MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Hsh2d重组蛋白
  • 货号：
    CSB-EP744289MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Hsh2d重组蛋白
  • 货号：
    CSB-EP744289MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Hsh2d重组蛋白
  • 货号：
    CSB-BP744289MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Hsh2d重组蛋白
  • 货号：
    CSB-MP744289MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Hsh2d
  • Uniprot No.：
  • 别名：
    Hsh2d; Alx; Hematopoietic SH2 domain-containing protein; Hematopoietic SH2 protein; Adaptor in lymphocytes of unknown function X
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-334
  • 氨基酸序列
    MAEARRLPPP LPPRLDWFVH TQADLLAQSG IPEWFHGTIS REAAENMLES QPLGTFLIRV SHSHVGYTLS YKAQTCCRHF MVKLSEDGTC AFAGDHMTHA SLHALVTFHQ QKPIRPFGEL LTQACGQEDP ANVDYEDLFL YSNALVQDAE SQILRTEVQR SSCPPEEASE RKPSTTTKGE FASASCSPKA LFEDSGQKLW KNLRSLPQTS QRVKQRLTSH LLAMNLLGDA RQVAQQHHSP VTRAFSWDST SHSEDSCAAT TSLQNPAEPQ ALRGREATFR DSRPASWRKA FSGVKAWRGK VVRALSAQEP VDFPEAQGWL PEEYLPPPPF APGY
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Adapter protein involved in tyrosine kinase and CD28 signaling. May be a modulator of the apoptotic response through its ability to affect mitochondrial stability.
  • 基因功能参考文献：
    1. These data demonstrate that changes in HSH2 expression have profound effects on the humoral immune response. PMID: 21873522
    2. ALX is an adaptor involved in T cell activation and interleukin-2 (IL-2) promoter activation PMID: 12960172
    3. endogenous HSH2 expression correlates directly with survival of WEHI-231 cells, which supports the hypothesis that HSH2 modulates the apoptotic response through its ability to directly or indirectly promote mitochondrial stability PMID: 15569688
    4. HSH2 expression is coordinately up-regulated with known antiapoptotic molecules and directly correlates with B cell survival PMID: 16547253
    5. These results suggest that ALX, in association with LAX, negatively regulates T-cell activation through inhibition of p38. PMID: 16880512
    6. Although adaptor in lymphocytes of unknown function X (ALX) is coexpressed with related adaptor Rlk/Itk-binding protein (RIBP) on both T- and B-lymphocytes throughout cell development, no redundancy or synergy is found. PMID: 17641043

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  • 亚细胞定位：
    Cytoplasm. Mitochondrion.
  • 组织特异性：
    Predominantly expressed in spleen and thymus. Appears not to be expressed in heart, brain, liver, kidney, embryo, lung and ovary.
  • 数据库链接：

    KEGG: mmu:209488

    STRING: 10090.ENSMUSP00000071970

    UniGene: Mm.157431