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  4. Recombinant Mouse Heat-stable enterotoxin receptor (Gucy2c), partial

Recombinant Mouse Heat-stable enterotoxin receptor (Gucy2c), partial

  • 货号：
    CSB-BP664972MO
  • 规格：
    ￥3168
  • 图片：
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他：

产品详情

  • 纯度：
    Greater than 85% as determined by SDS-PAGE.
  • 基因名：
  • Uniprot No.：
  • 别名：
    Gucy2c; Guc2c; Heat-stable enterotoxin receptor; STA receptor; EC 4.6.1.2; Guanylyl cyclase C; GC-C; Intestinal guanylate cyclase
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Extracellular Domain
  • 来源：
    Baculovirus
  • 分子量：
    51.1 kDa
  • 表达区域：
    20-433aa
  • 氨基酸序列
    VFWASQVRQNCRNGSYEISVLMMDNSAYKEPMQNLREAVEEGLDIVRKRLREADLNVTVNATFIYSDGLIHKSGDCRSSTCEGLDLLREITRDHKMGCALMGPSCTYSTFQMYLDTELNYPMISAGSYGLSCDYKETLTRILPPARKLMYFLVDFWKVNNASFKPFSWNSSYVYKNGSEPEDCFWYLNALEAGVSYFSEVLNFKDVLRRSEQFQEILTGHNRKSNVIVMCGTPESFYDVKGDLQVAEDTVVILVDLFSNHYFEENTTAPEYMDNVLVLTLPSEQSTSNTSVAERFSSGRSDFSLAYLEGTLLFGHMLQTFLENGENVTGPKFARAFRNLTFQGFAGPVTLDDSGDIDNIMSLLYVSLDTRKYKVLMKYDTHKNKTIPVAENPNFIWKNHKLPNDVPGLGPQILM
    Note: The complete sequence including tag sequence, target protein sequence and linker sequence could be provided upon request.
  • 蛋白标签：
    N-terminal 10xHis-tagged and C-terminal Myc-tagged
  • 产品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 缓冲液：
    Tris-based buffer，50% glycerol
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor for the E.coli heat-stable enterotoxin (E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GC-C). Also activated by the endogenous peptide guanylin.
  • 基因功能参考文献：
    1. Relative to controls, guanylate cyclase C knockout mice develop severe systemic illness following oral Salmonella infection, characterized by disrupted intestinal mucus layer, elevated cytokines and organ bacterial load, and reduced animal survival. PMID: 29367634
    2. Loss of Gucy2c expression is associated with Acute Radiation-Induced GI Syndrome. PMID: 28916678
    3. Findings show how caloric suppression of the guanylin-GUCY2C signaling axis links obesity to negation of a universal tumor suppressor pathway in colorectal cancer. PMID: 26773096
    4. The GC-C signaling pathway blunts colonic mucosal inflammation that is initiated by systemic cytokine burst or loss of mucosal immune cell immunosuppression. PMID: 24244444
    5. GC-C signaling is an essential component of host defense during murine enteric infection by reducing bacterial load and preventing systemic dissemination of attaching/effacing-lesion forming bacterial pathogens such as C. rodentium. PMID: 24004613
    6. guanylate cyclase-C PMID: 23739979
    7. GUCY2C opposes systemic genotoxic tumorigenesis by regulating AKT-dependent intestinal barrier integrity PMID: 22384056
    8. The role for GUCY2C-directed CD8(+) T cells targeting specific epitopes in antitumor efficacy. PMID: 22057677
    9. Data show that silencing of GUCY2C in mice disrupts satiation, resulting in hyperphagia and subsequent obesity and metabolic syndrome. PMID: 21865642
    10. a novel role for GC-C signaling in facilitating mucosal wounding and inflammation, and further suggest that this may be mediated, in part, through control of RELMbeta production PMID: 21555532
    11. midbrain dopamine neurons express GC-C; GC-C activation potentiates excitatory response mediated by glutamate and acetylcholine receptors via activity of PKG; GC-C knockout mice exhibit hyperactivity and attention deficit PMID: 21835979
    12. GCC signaling plays a protective role in the integrity of the intestinal mucosal barrier by regulating myosin light chain kinase activation and tight junction disassembly. PMID: 21305056
    13. There is a previously unappreciated interaction between sex and GCC signaling restricting crypt cell proliferation. PMID: 20443837
    14. GUCY2C is a tumor suppressor that controls proliferation and metabolism of intestinal epithelial cells by inactivating AKT signaling PMID: 19737566
    15. transmembrane guanylyl cyclase C is a key mediator of acid-stimulated duodenal bicarbonate secretion PMID: 12881226
    16. guanylin, uroguanylin, and E coli enterotoxin act on the mouse kidney, in part, through a cGMP-dependent, GC-C-independent mechanism, causing significant natriuresis by renal tubular processes PMID: 14675035
    17. two signaling pathways for guanylin peptides in principal cells of mouse cortical kidney collecting duct is not mediated by guanylate cyclase C PMID: 16105031
    18. GCC suppresses intestinal tumor initiation and growth by maintaining genomic integrity and restricting proliferation. PMID: 17681179
    19. GC-C coordinates component processes maintaining homeostasis of the crypt progenitor compartment. PMID: 17974601
    20. These findings demonstrate increased radiosensitivity of intestinal epithelial cells in guanylate cyclase C (GCC) knockout mice, and establish a role for GCC in preventing apoptosis. PMID: 19221018
    21. the role of the linker region in receptor guanylyl cyclases PMID: 19648115

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Adenylyl cyclase class-4/guanylyl cyclase family
  • 数据库链接：

    KEGG: mmu:14917

    STRING: 10090.ENSMUSP00000032338

    UniGene: Mm.222729