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  4. Recombinant Mouse Guanylate-binding protein 5 (Gbp5)

Recombinant Mouse Guanylate-binding protein 5 (Gbp5)

  • 货号：
    CSB-YP804498MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP804498MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP804498MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP804498MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP804498MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Gbp5; Guanylate-binding protein 5; EC 3.6.5.-; GTP-binding protein 5; GBP-5; MuGBP-5; Guanine nucleotide-binding protein 5
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-587
  • 氨基酸序列
    MAPEIHMPEP LCLIGSTEGH LVTNQEALKI LSAITQPVVV VAIVGLYRTG KSYLMNKLAG KEKGFSVGST VQSHTKGIWM WCVPHPQKPD HTLVLLDTEG LGDVEKDDKK NDTQIFALAI LLSSTFVYNT MNKIDQGAID LLHNVTELTD LLRTRNSSDS NQTEGEGPAD MSFFPDLVWT LRDFFLDLQA NGHAITSDEY LENSLKLKQG SDERTQTFNL PRLCIQKFFP VKKCFVFDAP ALGSKLSQLP TLSNEELNSD FVQDLSEFCS HIFTQSKTKT LPGGIQVNGP RLESLVLTYV DAINSGALPS IENTVVTLAR RENSAAVQKA IGHYDQLMSE KVQLPTETLQ ELLDLHRTCE REAIEIFRKH SFKDEGEFFQ KELESLLSAK QDEICKKNAD ASAALCSTLL GSIFKPLEQE VAQEFYHKPG GHKLFLQRME QLKANYRQQP GKGTQAEEVL QTYLNAKETV SRTILQTDQV LTDKEIQSKA EQERAEAARL EAQRLEAIRI QEEQRKAEME RQHQEQLRQI ALEKARVAQE QQWILKQRAQ EEADRIKAEQ EAQLRALQQQ LQHMREMNHH RRHHHDC
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    As an activator of NLRP3 inflammasome assembly, plays a role in innate immunity and inflammation. Promotes selective NLRP3 inflammasome assembly in response to microbial and soluble, but not crystalline, inflammasome activating agents. Hydrolyzes GTP, but in contrast to other family members, such as GBP1 and GBP2, does not produce GMP.
  • 基因功能参考文献：
    1. Genome-wide expression of isolated Kupffer cells following pressure-controlled hemorrhage revealed a significant increase of gene expression of Cxcl10, Il4ra, Csf2rb2, Lcn2, and Gbp5, which might represent new biomarkers for early diagnosis of post-traumatic complications. PMID: 27120970
    2. this study identified guanylate-binding proteins GBP2 and GBP5 as key activators of AIM2 during infection with F. novicida. PMID: 25774716
    3. Murine GBP-5, a new member of the murine guanylate-binding protein family, is coordinately regulated with other GBPs in vivo and in vitro. PMID: 12396730
  • 亚细胞定位：
    Cytoplasm. Golgi apparatus membrane; Lipid-anchor.
  • 蛋白家族：
    TRAFAC class dynamin-like GTPase superfamily, GB1/RHD3-type GTPase family, GB1 subfamily
  • 组织特异性：
    Low expression, if any, in many tissues in the absence of stimulation.
  • 数据库链接：

    KEGG: mmu:229898

    UniGene: Mm.459245