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  4. Recombinant Mouse Gremlin-2 (Grem2)

Recombinant Mouse Gremlin-2 (Grem2)

  • 货号：
    CSB-YP009893MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP009893MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP009893MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP009893MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP009893MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Grem2
  • Uniprot No.：
  • 别名：
    Grem2; Cktsf1b2; PrdcGremlin-2; Cysteine knot superfamily 1; BMP antagonist 2; Protein related to DAN and cerberus; PRDC
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    22-168
  • 氨基酸序列
    RKNRPAGAI PSPYKDGSSN NSERWHHQIK EVLASSQEAL VVTERKYLKS DWCKTQPLRQ TVSEEGCRSR TILNRFCYGQ CNSFYIPRHV KKEEDSFQSC AFCKPQRVTS VIVELECPGL DPPFRIKKIQ KVKHCRCMSV NLSDSDKQ
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Cytokine that inhibits the activity of BMP2 and BMP4 in a dose-dependent manner, and thereby modulates signaling by BMP family members. Contributes to the regulation of embryonic morphogenesis via BMP family members. Antagonizes BMP4-induced suppression of progesterone production in granulosa cells.
  • 基因功能参考文献：
    1. Grem2 knockdown inhibited cardiomyocyte differentiation, and this effect was similar to that of Notch1 pathway inhibition in vitro. Grem2 enhances the protective effect of cardiac progenitor cells on heart function in a mouse model of myocardial infarction. PMID: 29794428
    2. Grem2 provides a molecular barrier that controls the extent of inflammatory cell infiltration by suppressing BMP2 after myocardial infarction. PMID: 27283840
    3. Grem2 expression is regulated during development and embryonic stem cell differentiation. PMID: 24648383
    4. PRDC binds heparin with high affinity and that heparin binding to PRDC interferes with BMP antagonism. PMID: 23850456
    5. Through a combination of biophysical and biochemical studies, the s determined that PRDC forms biologically active dimers that potently inhibit BMP ligands. PMID: 23063586
    6. The differential regulation of Gremlin2 gene expressions by BMP2 may explain the critical function of these genes during osteoblast differentiation. PMID: 22644325
    7. ovarian PRDC expressed in granulosa cells could be involved in follicular development by antagonizing the actions of theca cell-derived Bone morphogenetic proteins PMID: 15039429
    8. We propose that PRDC might serve as a mediator to antagonize BMP-4 signaling by Wnt. PMID: 17222801
    9. PRDC expression in osteoblasts suppresses differentiation and that reduction of PRDC expression promotes osteogenesis in vitro. PRDC is accordingly identified as a potential novel therapeutic target for the regulation of bone formation. PMID: 19073177

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    DAN family
  • 组织特异性：
    Highly expressed in the ovary, followed by brain, spleen, colon, kidney and uterus. In ovary expressed in granulosa cells of selective early antral follicles.
  • 数据库链接：

    KEGG: mmu:23893

    STRING: 10090.ENSMUSP00000049640

    UniGene: Mm.25760