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  4. Recombinant Mouse Glycine receptor subunit alpha-2 (Glra2), partial

Recombinant Mouse Glycine receptor subunit alpha-2 (Glra2), partial

  • 中文名称：
    小鼠Glra2重组蛋白
  • 货号：
    CSB-YP766499MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Glra2重组蛋白
  • 货号：
    CSB-EP766499MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Glra2重组蛋白
  • 货号：
    CSB-EP766499MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Glra2重组蛋白
  • 货号：
    CSB-BP766499MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Glra2重组蛋白
  • 货号：
    CSB-MP766499MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Glra2
  • Uniprot No.：
  • 别名：
    Glra2Glycine receptor subunit alpha-2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Glycine receptors are ligand-gated chloride channels. Channel opening is triggered by extracellular glycine. Channel opening is also triggered by taurine and beta-alanine. Plays a role in the down-regulation of neuronal excitability. Contributes to the generation of inhibitory postsynaptic currents. Plays a role in cellular responses to ethanol.
  • 基因功能参考文献：
    1. These results, which reveal neurodevelopmental roles for alpha2-GlyRs in the adult brain, may be clinically relevant, given that a mutation in GLAR2, as well as Adult hippocampal neurogenesis impairments. PMID: 29057625
    2. Findings show that the loss of embryonic GlyRalpha2 ultimately impairs the formation of cortical circuits in the mature brain; results demonstrate a physiological role for alpha2 GlyRs during cortical network formation and homeostasis PMID: 26891984
    3. genetic inactivation of Glra2, the gene coding the alpha2 subunit of GlyRs, disrupts dorsal cortical progenitor homeostasis with an impaired capability of apical progenitors to generate basal progenitors. PMID: 24926615
    4. Endogenous activation of Glra2 promotes neuronal migration by regulating nucleokinesis. PMID: 23954789
    5. The distinct developmental regulation of GlyRalpha2 in the murine cochlea advocates a contribution of these chloride channels to efferent olivocochlear innervation. PMID: 21850450
    6. Findings are the first to define GlyR subunit-specific control of visual function and GlyRalpha2 subunit-specific control of crossover inhibition in the retina. PMID: 22399754
    7. Data suggest that GlyRalpha2, the developmentally expressed glycine receptor, may play an important role in neuronal development. PMID: 16847326
    8. Glycinergic sIPSCs of amacrine cells had slow kinetics (tau=27+/-6.8 ms) that were significantly prolonged in Glra2-/- mice (tau=69+/-16 ms). PMID: 17920294
    9. Glycine receptors (GlyRs) of group II cells are dominated by the alpha2 subunit; GlyRs of ON-starburst amacrine cells appear to be dominated by the alpha4 subunit. PMID: 19528249

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  • 亚细胞定位：
    Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell junction, synapse. Cell membrane; Multi-pass membrane protein. Cell projection.
  • 蛋白家族：
    Ligand-gated ion channel (TC 1.A.9) family, Glycine receptor (TC 1.A.9.3) subfamily, GLRA2 sub-subfamily
  • 组织特异性：
    Detected in the retina inner plexiform layer (at protein level). Detected in neonate retina. Detected in brain. Detected in spinal cord, with higher levels in the dorsal horn.
  • 数据库链接：

    KEGG: mmu:237213

    STRING: 10090.ENSMUSP00000060827

    UniGene: Mm.113877