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  4. Recombinant Mouse G0/G1 switch protein 2 (G0s2)

Recombinant Mouse G0/G1 switch protein 2 (G0s2)

  • 货号：
    CSB-YP730744MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP730744MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP730744MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP730744MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP730744MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    G0s2
  • Uniprot No.：
  • 别名：
    G0s2G0/G1 switch protein 2; G0S2-like protein
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-103
  • 氨基酸序列
    MESVQELIPL AKEMMAQKPR GKLVKLYVLG SVLALFGVVL GLVETVCSPF TAASRLRDQE AAVVELREAC EQQSLHKQAL LAGGKAQEAT LCSRALSLRQ HAS
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Promotes apoptosis by binding to BCL2, hence preventing the formation of protective BCL2-BAX heterodimers.
  • 基因功能参考文献：
    1. ER+ breast cancer cells with restored G0S2 expression had a relative increased sensitivity to tamoxifen PMID: 28910567
    2. G0S2 protein but not mRNA levels were reduced in the adipose tissue of ATGL-deficient mice, corroborating the involvement of ATGL in the stabilization of G0S2 PMID: 27248498
    3. G0S2 silencing mediates MYC-induced oncogenesis in other malignancies PMID: 26837760
    4. G0S2 expression in naive CD8(+) T cells decreased immediately after T-cell receptor activation downstream of various signal transduction pathways. G0S2 inhibits energy production by oxidative phosphorylation to fine-tune proliferation in homeostasis. PMID: 25666096
    5. findings do not rule out the possibility that G0S2 may be playing a role in other forms of leukemia, but clearly show that the commonly used Emu-Myc transgenic is not the correct model to conduct studies on G0s2 PMID: 26654706
    6. G0s2 is a physiological regulator of adiposity and energy metabolism and is a potential target in the treatment of obesity and insulin resistance. PMID: 25381555
    7. Proteasomal degradation of PPAR-gamma and the reduction of g0s2 content are permissive for prolonged TNF-alpha induced lipolysis. PMID: 24993166
    8. G0s2 has an important role in adipogenesis and accumulation of triacylglycerol. PMID: 24583640
    9. Roles for G0S2 were found in lactation, energy balance, and thermogenesis. This study provides a basis for tumor suppressive effects of G0S2 by regulating lipolysis. PMID: 24556704
    10. fat-specific G0S2 overexpression uncouples adiposity from insulin sensitivity and overall metabolic health through inhibiting adipose lipolysis and decreasing circulating fatty acids. PMID: 24302733
    11. Data indicate that downregulation of G0S2 in adipose tissue could represent one of the underlying causes leading to increased lipolysis in the insulin-resistant state. PMID: 22891293
    12. a novel model of HSC quiescence in which elevated G0S2 expression can sequester nucleolin in the cytosol, precluding its pro-proliferation functions in the nucleolus PMID: 22693613
    13. minimal fragment of ATGL could still be activated and inhibited by CGI-58 and G0S2, respectively PMID: 22039468
    14. Lipolysis is differently regulated between perigonadal and mesenteric adipocytes, and these depot-specific differences might be explained by altered regulation of G0S2 and/or perilipin. PMID: 21989031
    15. overexpression of G0S2 diminishes the rate of lipolysis in both adipocytes and adipose tissue explants PMID: 20197052
    16. A novel putative target gene of PPARalpha, G0S2 (G0/G1 switch gene 2) was identified and characterized. PMID: 16086669

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  • 亚细胞定位：
    Mitochondrion.
  • 数据库链接：

    KEGG: mmu:14373

    STRING: 10090.ENSMUSP00000009777

    UniGene: Mm.439721