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  4. Recombinant Mouse Forkhead box protein O6 (Foxo6)

Recombinant Mouse Forkhead box protein O6 (Foxo6)

  • 货号：
    CSB-YP008840MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP008840MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP008840MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP008840MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP008840MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Foxo6; Forkhead box protein O6
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-559
  • 氨基酸序列
    MAAKLRAHQV DVDPDFAPQS RPRSCTWPLP QPDLAGDEDG ALGAGVAEGS EDCGPERRAT APAMAPAPPL GAEVGPLRKA KSSRRNAWGN LSYADLITKA IESAPDKRLT LSQIYDWMVR YVPYFKDKGD SNSSAGWKNS IRHNLSLHTR FIRVQNEGTG KSSWWMLNPE GGKTGKTPRR RAVSMDNGAK FLRIKGKASK KKQLHLPERS PDDSPPGAPV PGPLSASAKW AASPASHASD DYEAWADFRG SRRPLLGEAA ELEDDEALEA LAPSSPLMYP SPASALSPAL GARCPGELPR LAELGGPLGL HGGGVAGLPD ALLDGAQDAY GPRARAGTPS YFGSCKASAY GGGGGFGPPA LGSLRRLPMQ TIQENKQASF VQAAAPFRPG ALPALLPPPP PAPRPGPLLG APGELALAGA AAAYPGKGAA PYAPPAPSRS ALAHPISLMT LPGEAGAAGL APPAHAAAFG GPPGGLLLDA LPGPYAAAAA GPLGAGPDRF PADLDLDMFS GSLECDVESI ILNDFMDSDE MDFNFDSALP PPPPGLAGAP PPNQSWVPG
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcriptional activator.
  • 基因功能参考文献：
    1. data indicate that FoxO6 depletion protected against diet-induced glucose intolerance and insulin resistance by attenuating hepatic gluconeogenesis and curbing macrophage infiltration in liver and adipose tissues in mice. PMID: 25944898
    2. FoxO6 is an important signaling molecule upstream of MTP for regulating hepatic VLDL-TG production PMID: 24437489
    3. Studies indicate that FoxO6 is produced in the liver of both rodents and humans. PMID: 23324123
    4. FoxO6 represses the expression of PGC-1alpha via direct binding to an upstream A/T-rich element (AAGATATCAAAACA,-2228-2215) in the PGC-1alpha promoter. PMID: 23639108
    5. FoxO6 regulates a program of genes involved in synaptic function upon learning in the hippocampus PMID: 23222102
    6. Central FoxO3a and FoxO6 expression is down-regulated in obesity induced diabetes but not in aging. PMID: 22187289
    7. investigation of role of FoxO6 in liver: Data suggest that a FoxO6-dependent pathway in liver orchestrates insulin regulation of gluconeogenesis. FoxO6 appears to be ubiquitously expressed in mouse tissues. PMID: 21940782
    8. cloning and characterization; structural and functional properties related to gene regulation PMID: 12857750
    9. FoxO factors mediate Myc-induced Arf expression and provide direct genetic evidence for their tumor-suppressive capacity. PMID: 17974917

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  • 亚细胞定位：
    Cytoplasm. Nucleus. Note=When phosphorylated, translocated from nucleus to cytoplasm. High nuclear localization after stimulation with growth factors.
  • 组织特异性：
    Expressed in brain in areas of the nucleus accumbens, cingulate cortex, parts of the amygdala and in the hippocampus.
  • 数据库链接：

    KEGG: mmu:329934

    STRING: 10090.ENSMUSP00000099716

    UniGene: Mm.277090