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  4. Recombinant Mouse Forkhead box protein N4 (Foxn4)

Recombinant Mouse Forkhead box protein N4 (Foxn4)

  • 中文名称：
    小鼠Foxn4重组蛋白
  • 货号：
    CSB-YP818349MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Foxn4重组蛋白
  • 货号：
    CSB-EP818349MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Foxn4重组蛋白
  • 货号：
    CSB-EP818349MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Foxn4重组蛋白
  • 货号：
    CSB-BP818349MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Foxn4重组蛋白
  • 货号：
    CSB-MP818349MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Foxn4
  • Uniprot No.：
  • 别名：
    Foxn4Forkhead box protein N4
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-521
  • 氨基酸序列
    MIESGIWSRM SEMIRSSGHS HHCSPQEYRF LPPVGDDDLP GDLQSLSWLT AVDVPRLQQM ANGRIDLGSS GVTHPHPGAL AGTADLHVGA APRPLLRRSQ TAVVPRGVLG LSPIGNHRAS AEQMNQFPAG GQASSGLQEM PQLYSPATQI PFPLPLGSQQ CPPAGLYGSP FSARPSYPQA HGAMHASQEP HPKHYPKPIY SYSCLIAMAL KNSKTGSLPV SEIYSFMKEH FPYFKTAPDG WKNSVRHNLS LNKCFEKVET KSSGSSRKGC LWALNLARID KMEEEMHKWK RKDLAAIHRS MANPEELDKL ISDRPESCRR PGKRGEPKAP MLTHATTVAM AHSCLAISQL PPKPLMTLSL QSVPLHHQLQ PQAHLAPDSP APAQTPPLHA LPSLSPGPLP QPAMGRVPGD FLNINSDMNT EVDALDPSIM DFALQGNLWE EMKEDSFSLD TLEAFGDSPL GCDLGAPSLT PVSGNSDQSF PDVQVTGLYA AYSTAADGVA PSAANSAQYL GTPGNKPIAL L
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription factor essential for neural and some non-neural tissues development, such as retina and lung respectively. Binds to an 11-bp consensus sequence containing the invariant tetranucleotide 5'-ACGC-3'. During development of the central nervous system, is required to specify the amacrine and horizontal cell fates from multipotent retinal progenitors while suppressing the alternative photoreceptor cell fates through activating DLL4-NOTCH signaling. Also acts synergistically with ASCL1/MASH1 to activate DLL4-NOTCH signaling and drive commitment of p2 progenitors to the V2b interneuron fates during spinal cord neurogenesis. In development of non-neural tissues, plays an essential role in the specification of the atrioventricular canal and is indirectly required for patterning the distal airway during lung development.
  • 基因功能参考文献：
    1. the mosaic expression of Foxn4 and proneural factors may serve as the trigger to initiate asymmetric Dll4-Notch and subsequent BMP/TGFbeta signaling events required for neuronal diversity in the V2 domain. PMID: 24257627
    2. Mouse Foxn4 transfection reduced by 2.7-fold the basal level of Tbx2 promoter transcription, but deletion of the AD domain increased transcription showing that this domain might be a transregulatory domain. PMID: 21701787
    3. Foxn4 has an intrinsic activity to suppress the alternative photoreceptor cell fates of early retinal progenitors by selectively activating Dll4-Notch signaling. PMID: 22323600
    4. Foxn4 may have a non-cell-autonomous role critical for alveologenesis during lung development. PMID: 21438071
    5. findings show that Foxn4 is required for proper outgrowth of retinal ganglion cell (RGC) axons in vivo, suggesting a role for an amacrine cell-RGC interaction in axon growth PMID: 21334440
    6. Foxn4 acts synergistically with Mash1 to specify subtype identity of V2 interneurons in the spinal cord. PMID: 16020526
    7. Foxn4 induces expression of delta-like 4 (Dll4) and Mash1 (Ascl1). Dll4 then signals through Notch1 to subdivide the p2 progenitor pool in the ventral spinal cord. PMID: 17728344
    8. expressed during neural development in the retina, the ventral hindbrain and spinal cord and dorsal midbrain PMID: 11520680

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Mainly expressed in proliferator progenitor cells in brain and retina rather than differentiated cells. In contrast, is expressed only in postmitotic epithelial cells rather than in proliferative progenitors in the proximal airway.
  • 数据库链接：

    KEGG: mmu:116810

    STRING: 10090.ENSMUSP00000047951

    UniGene: Mm.17709