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  4. Recombinant Mouse Forkhead box protein L1 (Foxl1)

Recombinant Mouse Forkhead box protein L1 (Foxl1)

  • 货号：
    CSB-YP727367MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP727367MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP727367MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP727367MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP727367MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Foxl1
  • Uniprot No.：
  • 别名：
    Foxl1; Fkh6; Fkhl11Forkhead box protein L1; Forkhead-related protein FKHL11; Transcription factor FKH-6
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-336
  • 氨基酸序列
    MSHLFSPPLA ALAASPLLYV YSPERPGLPL AFAPAAALAG PGRVEPPQKP PYSYIALIAM AIQDAPEQRV TLNGIYQFIM DRFPFYHDNR QGWQNSIRHN LSLNECFVKV PREKGRPGKG SYWTLDPRCL DMFENGNYRR RKRKPKPAAG SPEAKRTRVE PPESEVGCDV GSPDLATALP TRAPDRSQSP AVGTARPALL PWPGPEPRDP DADLTVQGAG AVASGQLQRP AHHLGSPLCP APSGSPKGSK SKSFSIDSIL AVRPTPASGA EAPGIPKPVP GALGSSLLAA SSGLAPPFNA SLVFDAHVQG GFSQLGIPFL SYFPLQVPEA TVLRFH
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription factor required for proper proliferation and differentiation in the gastrointestinal epithelium. Target gene of the hedgehog (Hh) signaling pathway via GLI2 AND GLI3 transcription factors.
  • 基因功能参考文献：
    1. SALL4 associated with the NuRD co-repressor and repressed expression of the tumor suppressor genes Foxl1 and Dusp4. PMID: 28867346
    2. Foxl1(+) hepatic progenitor cells and/or their descendants are required for the development of cholangiocytes and hepatocytes in liver injury models. PMID: 25286440
    3. Foxl1 might be involved in cellular responses of gut-associated lymphoid tissues dependent upon the Lymphotoxins/Lymphotoxin beta-receptor axis. PMID: 12648490
    4. link between a mesenchymal factor, Foxl1, and the regulation of a specific epithelial transport process in intestinal epithelium PMID: 15155178
    5. Mesenchymal Modifier of Min, plays a key role in gastrointestinal tumorigenesis. PMID: 15650110
    6. Foxl1 is a bona fide marker of the facultative progenitor cell in the mouse liver. PMID: 19105206
    7. promotes liver repair after bile-duct-ligation-induced liver injury through activation of the canonical wnt/beta-catenin pathway PMID: 19841618

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  • 亚细胞定位：
    Nucleus.
  • 数据库链接：

    KEGG: mmu:14241

    STRING: 10090.ENSMUSP00000137732

    UniGene: Mm.5111