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  4. Recombinant Mouse Forkhead box protein G1 (Foxg1)

Recombinant Mouse Forkhead box protein G1 (Foxg1)

  • 货号：
    CSB-YP736764MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP736764MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP736764MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP736764MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP736764MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Foxg1; Fkhl1; Foxg1b; Hfhbf1Forkhead box protein G1; FoxG1; Brain factor 1; BF-1; BF1; Forkhead-related protein FKHL1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-481
  • 氨基酸序列
    MLDMGDRKEV KMIPKSSFSI NSLVPEAVQN DNHHASHGHH NSHHPQHHHH HHHHHHPPPP APQPPPPPPQ QQQQQPPPAP QPPQARGAPA ADDDKGPQPL LLPPSTALDG AKADALGAKG EPGGGPAELA PVGPDEKEKG AGAGGEEKKG AGEGGKDGEG GKEGDKKNGK YEKPPFSYNA LIMMAIRQSP EKRLTLNGIY EFIMKNFPYY RENKQGWQNS IRHNLSLNKC FVKVPRHYDD PGKGNYWMLD PSSDDVFIGG TTGKLRRRST TSRAKLAFKR GARLTSTGLT FMDRAGSLYW PMSPFLSLHH PRASSTLSYN GTTSAYPSHP MPYSSVLTQN SLGNNHSFST ANGLSVDRLV NGEIPYATHH LTAAALAASV PCGLSVPCSG TYSLNPCSVN LLAGQTSYFF PHVPHPSMTS QTSTSMSARA ASSSTSPQAP STLPCESLRP SLPSFTTGLS GGLSDYFTHQ NQGSSSNPLI H
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription repression factor which plays an important role in the establishment of the regional subdivision of the developing brain and in the development of the telencephalon.
  • 基因功能参考文献：
    1. Foxg1 regulates the development of the epithalamus without the involvement of Shh and Fgfs. PMID: 29394901
    2. Prolyl-hydroxyproline promotes osteoblastic MC3T3-E1 cell differentiation and upregulation of osteogenic genes via Foxg1 expression. PMID: 29213293
    3. Foxg1 and Lhx2 form a genetic hierarchy in the spatiotemporal regulation of cortical hem specification and positioning, and together ensure the normal development of this hippocampal organizer. PMID: 29229772
    4. Study reports a new role for Foxg1 as a critical upstream regulator of the development of cortical interneurons. Conditional inactivation of Foxg1 in the subpallium led to significant upregulation of transcription factors such as Dlx1/2, Mash1, and Prox1. Foxg1 plays a cell-autonomous role in regulating the development of cortical interneurons. PMID: 26620267
    5. Foxg1 was found to play a role in promoting the closure of optic fissure. PMID: 28729440
    6. Report demonstrates the functional consequences of Foxg1 haploinsufficiency in the visual system of Foxg1+/Cre mice and a visual impairment in a cohort of Rett individuals presenting genetic alteration on FOXG1 PMID: 27001178
    7. findings suggest that different subcellular localizations of Foxg1 control the machinery that brings about cell differentiation, replication, and bioenergetics, possibly linking mitochondrial functions to embryonic development and pathological conditions PMID: 26508630
    8. This study demonistrated that Celsr3/Foxg1 mutation mice show the spinal motor network does not mature fully in the absence of corticofugal connections, and that some motor function is preserved despite congenital absence of the corticospinal tract. PMID: 24012835
    9. Foxg1 as a key coordinator of the early transcriptional network during the course of cortical development. PMID: 23523356
    10. Targets of RBPJ/N1ICD in cortical neural stem cell at a genome-wide level, were identified PMID: 22232070
    11. the dynamic expression of FoxG1 during migration within the intermediate zone is essential for the proper assembly of the cerebral cortex. PMID: 22726835
    12. We conclude that Foxg1 exerts control over telencephalic progenitor proliferation by cell autonomous mechanisms that include the regulation of Pax6 PMID: 21418559
    13. The survival-promoting activity of FoxG1 in neurons is mediated by the PI-3 kinase-Akt signaling pathway, and FoxG1 is a downstream target of IGF-1-mediated signal transduction. PMID: 21228151
    14. Foxg1 acts cell-autonomously in the telencephalon to ensure that cells develop the competence to adopt ventral identities. PMID: 20081193
    15. Our genetic fate-mapping analyses indicate an improper separation between anterior and lateral cristae in Foxg1(-/-) mutants. Our data further suggest that a function of Foxg1 in the inner ear is to restrict sensory fate. PMID: 19842177
    16. Lack of Pax6 or Foxg1 disrupts early events in thalamocortical tract formation; Foxg1(-/-) embryos lack recognizable ventral telencephalic structures PMID: 12351726
    17. demonstrated that the generation of the earliest born neurons, the Cajal-Retzius cells, is suppressed by the telencephalic transcription factor Foxg1 PMID: 14704420
    18. Results suggest that the Foxg1 knockout phenotype reflects at least in part a requirement for Foxg1 out with the retinal ganglion cells themselves, most likely at the optic chiasm. PMID: 15240555
    19. Study reinforces Foxg1's position as a major regulator of telencephalic neurogenesis and supports the idea that Foxg1 controls precursor proliferation via regulation of Fgf signaling. PMID: 15893304
    20. Grg6 is expressed in cortical neural progenitor cells, interacts with BF-1, and plays a role in in cortical neuron development. PMID: 16314515
    21. Foxg1 is expressed in most cell types of the inner ear of the adult mouse, and Foxg1 mutants have both morphological and histological defects in the inner ear. PMID: 16691564
    22. Although links between FoxG1 haploinsufficiency and either failed postnatal DG neurogenesis or the behavioral deficits remain to be elucidated, these results are a new model system for impaired postnatal neurogenesis in the mouse DG. PMID: 16941454
    23. Casein kinase I and FGF signalling converge on an antagonistic regulation of FoxG1, which in turn controls neurogenesis in the forebrain. PMID: 17435750
    24. The role of Foxg1 is regulate cortical development, reveal noteworthy complexity in the of specific mechanisms underlying phenotypes expressed following genetic manipulations and stress the importance of including appropriate controls of all genotypes. PMID: 17640820
    25. Represses generation of Cajal-Retzius (CR) cells in the cortical hem region of high bone morphogenetic proteins and Wnt (wingless-type mouse mammary tumor virus integration site family) and pallial-subpallial boundary-derived CR cells. PMID: 17928452
    26. During corticogenesis, Foxg1-regulated activities enable the expansion of the intermediate progenitor cell population, likely through suppression of p21-dependent cell-cycle exit. PMID: 18065723
    27. Foxg1 is required cell-autonomously for the production of mature olfactory receptor neurons. Therefore, we identified an evolutionarily conserved requirement for Foxg1 in the development of the vertebrate olfactory system. PMID: 18480279
    28. MiR-9 negatively regulates endogenous Foxg1 protein level. MiR-9 overexpression in developing telencephalon at E11.5 resulted in ectopic Reelin-positive cells over cortex beyond marginal zone. PMID: 18842901
    29. in chiasm cells, Foxg1 is required for the generation of a hitherto unrecognized activity supporting RGC axon growth PMID: 19004857

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    CNS, and nasal half of the retina.
  • 数据库链接：

    KEGG: mmu:15228

    STRING: 10090.ENSMUSP00000021333

    UniGene: Mm.4704