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  4. Recombinant Mouse Forkhead box protein D3 (Foxd3)

Recombinant Mouse Forkhead box protein D3 (Foxd3)

  • 货号：
    CSB-YP717193MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP717193MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP717193MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP717193MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP717193MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Foxd3; Hfh2Forkhead box protein D3; HNF3/FH transcription factor genesis; Hepatocyte nuclear factor 3 forkhead homolog 2; HFH-2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-465
  • 氨基酸序列
    MTLSGSGSAS DMSGQTVLTA EDVDIDVVGE GDDGLEEKDS DAGCDSPAGP PDLRLDEADE GPPVSAHHGQ SQPQALALPT EATGPGNDTG APEADGCKGG EDAVTGGGGP GAGSGATGGL TPNKPKNSLV KPPYSYIALI TMAILQSPQK KLTLSGICEF ISNRFPYYRE KFPAWQNSIR HNLSLNDCFV KIPREPGNPG KGNYWTLDPQ SEDMFDNGSF LRRRKRFKRH QQEHLREQTA LMMQSFGAYS LAAAAGAGPY GLHPAAAAGA YSHPAAAAAA AAAAALQYPY ALPPVAPVLP PAVPLLPSGE LGRKAAAFGS QLGPSLQLQL NTLGAAAAAA GTAGAAGTTS LIKSEPSARP SFSIENIIGA GSAAPGGSAG GGGSGGGAGG GGGSGGGGGA QSFLRPPGTV QSAALMATHQ PLSLSRTTAT IAPILSVPLS GQFLQPAASA AAAAAAAVQA KWPAQ
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis.
  • 基因功能参考文献：
    1. FOXD3-AS1 serves as a sponge or as a competing endogenous noncoding RNA for miR-150, restricting its capability to promote cell growth and thereby exaggerating hyperoxia-induced lung epithelial cell death PMID: 28655711
    2. suggest that CHD7, Oct3/4, Sox2, and Nanog directly induce FoxD3 expression when stimulated by BMP2/Wnt3a signaling, that FoxD3 promotes Sox10 expression, and that histone H3K4 methylation play important roles in this process of neural crest-derived stem cell formation PMID: 27579714
    3. this study shows that Foxd3 suppresses the production of IL-10+ Breg cells by directly binding the IL-10 promoter PMID: 27995618
    4. FOXD3 modulates the developmental potential of pluripotent cells as they differentiate PMID: 26748757
    5. analysis of a cycle of activation and deactivation of Foxd3 required for exit from naive pluripotency and subsequent primordial germ cell specification PMID: 26748758
    6. Foxd3 poises enhancers in pluripotent stem cells by recruiting multiple epigenetic enzymes that together simultaneously initiate and repress enhancer activity. PMID: 26748757
    7. Foxd3 suppresses NFAT-mediated differentiation to maintain self-renewal of embryonic stem cells PMID: 25378483
    8. In a xenograft tumor model, FOXD3 overexpression inhibits tumor growth and angiogenesis. PMID: 26341266
    9. Data indicate that homeobox b5 (Hoxb5) regulated the neural crest (NC)development by directly inducing Forkhead box D3 gene (Foxd3). PMID: 25220476
    10. Foxd3 induced mutant ESCs precociously express genes required for mesoderm induction, but they are likely unable to differentiate into skeletal muscle. PMID: 24270162
    11. Foxd3 deficiency completely abolishes the sphere-forming potential of skin embryonic stem cells. PMID: 23316968
    12. Foxd3 is part of a dynamically expressed gene network that is necessary and sufficient to regulate fate decisions in premigratory neural crest cells. PMID: 23615280
    13. Methylation profile analyses identified the promoter of FOXD3 as the only genomic region with increased methylation in mice and humans during progression of Helicobacter pylori-associated gastric tumors. PMID: 23058321
    14. The findings highlighted the crucial roles played by Foxd3 during enteric nervous system development including progenitor proliferation, neural patterning, and glial differentiation. PMID: 22266424
    15. Foxd3 is upstream of several pathways critical for beta-cell mass expansion in vivo. PMID: 21952247
    16. Foxd3 and Pax3 act together to affect survival and maintenance of cardiac NC progenitors, and loss of these progenitors catastrophically affects key aspects of later cardiovascular development. PMID: 21254333
    17. show that Foxd3 mediates a fate restriction choice for multipotent neural crest (NC) progenitors with loss of Foxd3 biasing NC toward a mesenchymal fate PMID: 21228004
    18. In ESCs, binding of Foxd3 suppresses intergenic transcription of the enhancer and surrounding sequences. PMID: 20621055
    19. Trophoblast progenitors in Foxd3-/- embryos do not self-renew and are not multipotent, but instead give rise to an excess of trophoblast giant cells. PMID: 16039639
    20. Foxd3 transcriptional repressor plays role in all aspects of neural crest maintenance along the anterior-posterior axis, and establish an unprecedented molecular link between multiple divergent progenitor lineages of the mammalian embryo. PMID: 18367558
    21. A model for the role of Foxd3 in repressing differentiation, promoting self-renewal, and maintaining survival of mouse embryonic stem cells, is presented. PMID: 18653770

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Expressed in premigratory and migrating neural crest cells in the early embryo and in motorneuron and interneuron progenitors in the developing spinal cord.
  • 数据库链接：

    KEGG: mmu:15221

    STRING: 10090.ENSMUSP00000084541

    UniGene: Mm.4758