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  4. Recombinant Mouse Forkhead box protein C1 (Foxc1)

Recombinant Mouse Forkhead box protein C1 (Foxc1)

  • 货号：
    CSB-YP723416MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP723416MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP723416MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP723416MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP723416MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Foxc1
  • Uniprot No.：
  • 别名：
    Foxc1; Fkh1; Fkhl7; Freac3; Mf1Forkhead box protein C1; Forkhead-related protein FKHL7; Forkhead-related transcription factor 3; FREAC-3; Mesoderm/mesenchyme forkhead 1; MF-1; Transcription factor FKH-1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-553
  • 氨基酸序列
    MQARYSVSSP NSLGVVPYLG GEQSYYRAAA AAAGGGYTAM PAPMSVYSHP AHAEQYPGSM ARAYGPYTPQ PQPKDMVKPP YSYIALITMA IQNAPDKKIT LNGIYQFIMD RFPFYRDNKQ GWQNSIRHNL SLNECFVKVP RDDKKPGKGS YWTLDPDSYN MFENGSFLRR RRRFKKKDAV KDKEEKGRLH LQEPPPPQAG RQPAPAPPEQ AEGSAPGPQP PPVRIQDIKT ENGTCPSPPQ PLSPAAALGS GSAATVPKIE SPDSSSSSLS SGSSPPGSLP SARPLSLDAA EPAPPPQPAP PPHHSQGFSV DNIMTSLRGS PQGSAAELGS GLLASAAASS RAGIAPPLAL GAYSPGQSSL YSSPCSQSSS AGSSGGGGGG GGGGGGSSSA AGTGGAATYH CNLQAMSLYA AGERGGHLQG PAGGAGSAAV DDPLPDYSLP PATSSSSSSL SHGGGGQEAS HHPASHQGRL TSWYLNQAGG DLGHLASAAA AAAAAGYPGQ QQNFHSVREM FESQRIGLNN SPVNGNSSCQ MAFPASQSLY RTSGAFVYDC SKF
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    DNA-binding transcriptional factor that plays a role in a broad range of cellular and developmental processes such as eye, bones, cardiovascular, kidney and skin development. Acts either as a transcriptional activator or repressor. Binds to the consensus binding site 5'-[G/C][A/T]AAA[T/C]AA[A/C]-3' in promoter of target genes. Upon DNA-binding, promotes DNA bending. Acts as a transcriptional coactivator. Stimulates Indian hedgehog (Ihh)-induced target gene expression mediated by the transcription factor GLI2, and hence regulates endochondral ossification. Acts also as a transcriptional coregulator by increasing DNA-binding capacity of GLI2 in breast cancer cells. Regulates FOXO1 through binding to a conserved element, 5'-GTAAACAAA-3' in its promoter region, implicating FOXC1 as an important regulator of cell viability and resistance to oxidative stress in the eye. Cooperates with transcription factor FOXC2 in regulating expression of genes that maintain podocyte integrity. Promotes cell growth inhibition by stopping the cell cycle in the G1 phase through TGFB1-mediated signals. Involved in epithelial-mesenchymal transition (EMT) induction by increasing cell proliferation, migration and invasion. Involved in chemokine CXCL12-induced endothelial cell migration through the control of CXCR4 expression. Plays a role in the gene regulatory network essential for epidermal keratinocyte terminal differentiation. Essential developmental transcriptional factor required for mesoderm-derived tissues formation, such as the somites, skin, bone and cartilage. Positively regulates CXCL12 and stem cell factor expression in bone marrow mesenchymal progenitor cells, and hence plays a role in the development and maintenance of mesenchymal niches for haematopoietic stem and progenitor cells (HSPC). Plays a role in corneal transparency by preventing both blood vessel and lymphatic vessel growth during embryonic development in a VEGF-dependent manner. May function as a tumor suppressor.
  • 基因功能参考文献：
    1. Targeting EZH2 reactivates a breast cancer subtype-specific anti-metastatic transcriptional program driven by FOXC1. PMID: 29959321
    2. These findings suggest that Foxc1 is an important regulator to further chondrogenesis and initiate the ossification of the presphenoid and basisphenoid bones. PMID: 29322554
    3. Lineage tracing experiments in Foxc1 mutant mouse cerebella indicate that aberrant migration of granule cell progenitors destined to form the posterior-most lobule causes this cerebellar malformation phenotype. PMID: 28092268
    4. Foxc1 regulates both early cardiomyogenesis and the functional properties of embryonic stem cell-derived cardiomyocytes. PMID: 26824887
    5. FOXC1 and FOXC2 are essential regulators of lymphangiogenesis and may have roles in lymphatic-associated diseases PMID: 27214551
    6. These data indicate that Foxc1 expression is regulated by BMP4 and FOXC1 functions in the commitment of progenitor cells to the osteoblast fate and its expression is reduced when differentiation proceeds. PMID: 26666591
    7. Foxc1 regulates sweat duct luminal cell differentiation and mimic apocrine miliaria. PMID: 27592801
    8. Compound, NC-specific Foxc1; Foxc2 homozygous mutant mice have more severe defects in structures of the ocular surface, such as the cornea and eyelids, accompanied by significant declines in the expression of another key developmental factor, Pitx2, and its downstream effector Dkk2, which antagonizes canonical Wnt signaling. PMID: 28253399
    9. These findings offer the first evidence for a role of the meninges in brain vascular development and provide new insight into potential causes of cerebrovascular defects in patients with FOXC1 mutations. PMID: 27671872
    10. Foxc1 and Foxc2 maintain glomerular podocyte integrity by regulating the gene expression. PMID: 28223138
    11. Foxc1 and Foxc2 have a role in kidney and axial skeleton development. PMID: 27193493
    12. FOXC1 maintains the hair follicle stem cell niche and governs stem cell quiescence to preserve long-term tissue-regenerating potential.FOXC1 is necessary to establish a multiple-bulge hair follicle architecture. PMID: 26912458
    13. deletion of Foxc1 and Foxc2 specifically in Pax3-positive cells affects cell fate choices in the dermomyotome of somites at forelimb level, promoting the myogenic cell fate at the expense of endothelial cells that migrate to the limb PMID: 26839363
    14. Foxc1 is an important transcriptional partner of Ihh-Gli2 signalling during endochondral ossification, and that disruption of the Foxc1-Gli2 interaction causes skeletal abnormalities observed in the Axenfeld-Rieger syndrome. PMID: 25808752
    15. In self-renewing stem cells (SCs), Foxc1 activates Nfatc1 and bone morphogenetic protein (BMP) signaling, two key mechanisms that govern quiescence. These findings reveal a dynamic, cell-intrinsic mechanism used by hair follicle SCs to reinforce quiescence upon self-renewal and suggest a unique ability of SCs to maintain cell identity. PMID: 26912704
    16. These observations reveal an essential role for Foxc1 in the early stage of vascular formation in the telencephalon. PMID: 25733312
    17. loss of Foxc1 non-autonomously induces a rapid and devastating decrease in embryonic cerebellar ventricular zone radial glial proliferation and concurrent increase in cerebellar neuronal differentiation PMID: 25513817
    18. A loss of Foxc1 function affects skull bone formation of the apical region. PMID: 24417671
    19. Together our data demonstrates that Foxc1 - Fgf8 signaling regulates mammalian jaw patterning and provides a mechanistic basis for the pathogenesis of syngnathia. PMID: 24385915
    20. identification of Foxc1 as a specific transcriptional regulator essential for development and maintenance of the mesenchymal niches for haematopoietic stem and progenitor cells PMID: 24590069
    21. FOXC1 is unnecessary for mammary morphogenesis; role in basal-like breast cancer likely involves processes that are unrelated to cell lineage specification. PMID: 23677979
    22. Upper pole kidneys of newborn Foxc1(ch/ch) mice were significantly more hypoplastic and contained significantly fewer glomeruli than their lower pole counterparts. PMID: 23838094
    23. These data indicate that Foxc1 expression leads to a similar enhanced osteogenic differentiation phenotype as observed with Msx2 overexpression PMID: 23145080
    24. Foxc1 sets a threshold for the Bmp-dependent activation of Msx2, thus controlling the differentiation of osteogenic precursor cells and the rate and pattern of calvarial bone development. PMID: 23344708
    25. A territorial correlation is identified between meningeal defects and disruption of interneuron migration along the adjacent marginal zone in the cerebral cortex of Foxc1-deficient mice. PMID: 22248045
    26. These findings identify a role for FoxC1 in inhibiting corneal angiogenesis. PMID: 22171010
    27. These data provide evidence that the Foxf2 gene, separated from Foxc1 by less than 70 kb of genomic sequence (250 kb in human DNA), may explain human abnormalities in some cases of ASD where FOXC1 has been excluded genetically. PMID: 22022403
    28. Cortical dysplasia resembling cobblestone cortex, with basement membrane breakdown and lamination defects, is seen in Foxc1 mutants PMID: 20976766
    29. Progression of calvarial bone development requires Foxc1 regulation of Msx2 and Alx4. PMID: 14512019
    30. FGF2 regulates the expression of Foxc1, indicating that Foxc1 integrates Bmp and Fgf signalling pathways PMID: 15906377
    31. alongside its previously known roles in kidney, cardiovascular and eye development, Foxc1 has essential functions during at least two stages of gonad development-germ cell migration and folliculogenesis PMID: 16412416
    32. Foxc1 mediates the bone morphogenetic protein signaling required for lacrimal gland development. PMID: 16470615
    33. Results demonstrate that Foxc1 and 2 transcription factors are novel regulators of arterial cell specification upstream of Notch signaling and lymphatic sprouting during embryonic development. PMID: 16678147
    34. Analysis of the regulation of Tgf beta1i4 by Foxc1 in mesenchymal cells isolated from the periocular region revealed that Foxc1 negatively regulated Tgf beta1i4 expression, presumably via secreted factors such as TGF-beta1. PMID: 16759280
    35. Foxc1 is required for the development of the second heart field where the outflow tract, right ventricle, and part of the atrium and inflow tract are derived from a second cell lineage encompassing the secondary heart field. PMID: 16839542
    36. defects in meningeal differentiation caused by mutations in Foxc1 can lead to severe cortical dysplasia. PMID: 17715063
    37. These results provide novel evidence that Foxc transcription factors are important regulators of the chemotactic motility of endothelial cells through the induction of CXCR4 expression. PMID: 18187037

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  • 亚细胞定位：
    Nucleus.
  • 组织特异性：
    Expressed in glomerular epithelial cells, the podocytes. Expressed in a population of adipo-osteogenic progenitor cells, termed CXCL12-abundant reticular (CAR) cells (at protein level). Expressed in many embryonic tissues, including prechondrogenic mesenc
  • 数据库链接：

    KEGG: mmu:17300

    STRING: 10090.ENSMUSP00000052196

    UniGene: Mm.12949