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  4. Recombinant Mouse Fibulin-5 (Fbln5)

Recombinant Mouse Fibulin-5 (Fbln5)

  • 货号：
    CSB-YP895768MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP895768MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP895768MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP895768MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP895768MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Fbln5; Dance; Fibulin-5; FIBL-5; Developmental arteries and neural crest EGF-like protein; Dance
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    24-448
  • 氨基酸序列
    QQQCTNG FDLDRQSGQC LDIDECRTIP EACRGDMMCV NQNGGYLCIP RTNPVYRGPY SNPYSTSYSG PYPAAAPPVP ASNYPTISRP LVCRFGYQMD EGNQCVDVDE CATDSHQCNP TQICINTEGG YTCSCTDGYW LLEGQCLDID ECRYGYCQQL CANVPGSYSC TCNPGFTLND DGRSCQDVNE CETENPCVQT CVNTYGSFIC RCDPGYELEE DGIHCSDMDE CSFSEFLCQH ECVNQPGSYF CSCPPGYVLL DDNRSCQDIN ECEHRNHTCT SLQTCYNLQG GFKCIDPISC EEPYLLIGEN RCMCPAEHTS CRDQPFTILY RDMDVVSGRS VPADIFQMQA TTRYPGAYYI FQIKSGNEGR EFYMRQTGPI SATLVMTRPI KGPRDIQLDL EMITVNTVIN FRGSSVIRLR IYVSQYPF
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Essential for elastic fiber formation, is involved in the assembly of continuous elastin (ELN) polymer and promotes the interaction of microfibrils and ELN. Stabilizes and organizes elastic fibers in the skin, lung and vasculature. Promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. Vascular ligand for integrin receptors which may play a role in vascular development and remodeling. May act as an adapter that mediates the interaction between FBN1 and ELN.
  • 基因功能参考文献：
    1. Fibulin-5 overexpression promoted the proliferation and migration of airway smooth muscle cell. PMID: 28942149
    2. Fibulin-5 overexpression significantly down-regulated the phosphorylation level of eIF2alpha and subsequently inhibited the TRPV1 channel and CREB/CGRP signaling PMID: 28602628
    3. Identify a SOX9/HDAC-dependent mechanism involved in the down-regulation of FBLN5 by inflammation in abdominal aortic aneurysms. PMID: 27089918
    4. involved in the stiffening of fibrotic tissue PMID: 26469761
    5. Data indicate that Fbln5 promotes PDAC progression by functioning as a molecular rheostat that modulates cell-ECM interactions to reduce ROS production, and thus tip the balance in favor of tumor cell survival and treatment-refractory disease. PMID: 26577699
    6. While premaxillo-maxillary suture mesenchymal cells in fibulin-5-null mice were capable of differentiating into osteoblasts, suture cells in mutant mice were less proliferative. PMID: 26399686
    7. Fibulin-5 plays critical roles in proliferation, migration and invasion of certain tumors, and the effect of fibulin-5 on tumorigenesis appears to be largely context-dependent. (Review) PMID: 25845228
    8. These results are consistent with a role for TGFbeta2 in lung septation and for Ltbp4 in regulating fibulin-5 dependent elastic fiber assembly. PMID: 24962333
    9. Without LTBP-4, fibulin-5 and tropoelastin deposition was discontinuous and punctate in vitro and in vivo PMID: 23382201
    10. This study used the maturation of fibulin-5 knockout (KO) and wild-type mice to study the effects of fragmented elastic fibers on the growth and remodeling of carotid arteries. PMID: 23241326
    11. suggest that uPA promotes cell migration by binding to fibulin-5, initiating its cleavage by plasmin, which leads to its dissociation from beta1-integrin and thereby unblocks the capacity of integrin to facilitate cell motility PMID: 22280367
    12. MMP9 and fibulin-5 have roles in progression of pelvic organ prolapse in mice and humans PMID: 21519142
    13. mechanical testing and confocal imaging of common carotid arteries from fibulin-5 null mice and littermate controls to characterize the mechanical behavior and microstructural content of these arteries PMID: 20614245
    14. These findings introduce a novel function for Fbln5 in the regulation of integrin-induced reactive oxygen species production. PMID: 20197418
    15. Fibulin-2 and fibulin-5 cooperatively function to form the internal elastic lamina during postnatal development by directing the assembly of elastic fibers, and are responsible for maintenance of the adult vessel wall after injury PMID: 19893004
    16. Fibulin-5 is a calcium-dependent, elastin-binding protein that localizes to the surface of elastic fibres in vivo. PMID: 11805834
    17. FBLN-5 is a novel TGF-beta-inducible target gene that regulates cell growth and motility in a context-specific manner and affects protein kinase activation by TGF-beta. PMID: 12021267
    18. coordinately expressed and regulated with elastin in lung fibroblasts and may serve a key role during lung injury and repair. PMID: 12909585
    19. The alterations in elastogenesis associated with increased fibulin-2 in hypodermal connective tissues and decreased fibulin-5 at the hypodermal M-CT interface suggest that these proteins mediate the effect of Tsk-fibrillin-1 on elastogenesis. PMID: 15610515
    20. role of fbln-5 as an inhibitor of vascular smooth muscle cell proliferation and migration. PMID: 15710889
    21. Fibulin-5 and elastic fibers are not directly involved in short-term wound healing. PMID: 16902421
    22. Fibulin-5 serves as an adaptor molecule between monomeric elastin and the matrix scaffold to aid in elastic fiber assembly. PMID: 17130242
    23. Mouse models of genetic macular degeneration include studies on Fbln5. PMID: 17368622
    24. These results suggest a novel regulatory mechanism of elastic fiber assembly in which LTBP-2 regulates targeting of DANCE on suitable microfibrils to form elastic fibers. PMID: 17581631
    25. the normal angiogenic process is enhanced in the absence of fibulin-5. PMID: 17607303
    26. a novel Epithelial-mesenchymal transition and tumor-promoting function for FBLN5 in developing and progressing breast cancers PMID: 18713838
    27. Fibulin 5(-/-) mice develop prolapse by 6 mo of age, even in the absence of vaginal delivery, and increased vaginal protease activity (MMP-2 and MMP-9) precedes the development of prolapse. PMID: 18987327
    28. Fibulin-5 plays 2 roles in elastogenesis; 1st, limiting the extent of aggregation of tropoelastin monomers and/or coacervates and aiding the incorporation of elastin into the microfibril bundles, & 2nd, potentially assisting in the activation of LOXL-1. PMID: 19321153

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  • 亚细胞定位：
    Secreted. Secreted, extracellular space, extracellular matrix.
  • 蛋白家族：
    Fibulin family
  • 数据库链接：

    KEGG: mmu:23876

    STRING: 10090.ENSMUSP00000021603

    UniGene: Mm.288381