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  4. Recombinant Mouse Fibroblast growth factor 18 (Fgf18)

Recombinant Mouse Fibroblast growth factor 18 (Fgf18)

  • 货号：
    CSB-YP008623MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP008623MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP008623MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP008623MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP008623MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Fgf18Fibroblast growth factor 18; FGF-18; zFGF5
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    28-207
  • 氨基酸序列
    EEN VDFRIHVENQ TRARDDVSRK QLRLYQLYSR TSGKHIQVLG RRISARGEDG DKYAQLLVET DTFGSQVRIK GKETEFYLCM NRKGKLVGKP DGTSKECVFI EKVLENNYTA LMSAKYSGWY VGFTKKGRPR KGPKTRENQQ DVHFMKRYPK GQAELQKPFK YTTVTKRSRR IRPTHPG
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays an important role in the regulation of cell proliferation, cell differentiation and cell migration. Required for normal ossification and bone development. Stimulates hepatic and intestinal proliferation.
  • 基因功能参考文献：
    1. Study found that Fgf18 mRNA was one of the spinal motor neurons (SMNs)-specific FGFs in adult mice. Fgf18 mRNA was expressed in the spinal cord, and to a lesser extent in the diaphragm, in mouse embryos. In C2C12 myotubes, FGF18 enhanced AChR clustering. These data propose that FGF18 plays a pivotal role in AChR clustering and NMJ formation in mouse embryogenesis. PMID: 29323161
    2. Elevation of FGF signaling, mainly due to increased Fgf18 expression upon inactivation of Evc2 in the perichondrium, critically contributes to the pathogenesis of limb dwarfism. The limb dwarfism phenotype is partially rescued by inactivation of one allele of Fgf18 in the Evc2 mutant mice PMID: 28027321
    3. Loss of alleles of Fgf9 and Fgf18 also affect the expression of genes encoding other key intrinsic skeletal regulators, including IHH, PTHLH (PTHrP), and RUNX2, revealing potential direct, indirect, and compensatory mechanisms to coordinate chondrogenesis and osteogenesis. PMID: 26794256
    4. retinoic acid is produced by pulmonary endothelial cells and regulates pulmonary angiogenesis and elastin synthesis by induction of VEGF-A and fibroblast growth factor (FGF)-18, respectively PMID: 26566904
    5. novel Shh-Foxf-Fgf18-Shh circuit in the palate development molecular network, in which Foxf1 and Foxf2 regulate palatal shelf growth downstream of Shh signaling, at least in part, by repressing Fgf18 expression PMID: 26745863
    6. post-natal induction of chondrocyte autophagy is mediated by the growth factor FGF18 through FGFR4 and JNK-dependent activation of the autophagy initiation complex VPS34-beclin-1 PMID: 26595272
    7. Phlpp1 deficiency increases Akt2 activity, which diminishes FoxO1 levels and induces Fgf18 expression to stimulate chondrocyte proliferation. PMID: 25953896
    8. Foxp1 regulates the quiescent stem cell state in the hair follicle stem cell niche by controlling Fgf18 expression. PMID: 23946441
    9. These findings therefore argue for an involvement of FGF18 in the control of various developmental events during the alveolar stage. PMID: 21878612
    10. Fgf-18 is an important mediator of bone regeneration, which is required during later stages of bone regeneration. PMID: 21457097
    11. FGF18 is upregulated during osteoblast differentiation induced by dexamethasone in murine mesenchymal stem cells. PMID: 20432451
    12. Regulation of Hmgn1 and Fgf18 at the digit-interdigit junction suggests retinoic acid controls tissue remodeling as well as apoptosis. PMID: 20034106
    13. Data revealed interaction between Glg1 and Fgf18 both genetically and physically and reveals a novel regulatory mechanism for Fgf18 signaling involving Glg1 and Dlk. PMID: 20023171
    14. The expression from early streak stage to midgestation of Fgf18 is measured. It is, closely related to Fgf8 (56.8% identical at the amino acid level). Fgf18 RNA is not expressed until later, in paraxial mesoderm. PMID: 9651520
    15. FGF-18 may therefore compensate for the action of FGF-2 on bone and cartilage. PMID: 11741978
    16. expression of FGF18 in calvarial and limb development PMID: 11900978
    17. Fibroblast growth factor 18 influences proximal programming during lung morphogenesis PMID: 11927601
    18. Coordination of chondrogenesis and osteogenesis by fibroblast growth factor 18 PMID: 11937493
    19. FGF18 is required for normal cell proliferation and differentiation during osteogenesis and chondrogenesis PMID: 11937494
    20. FGF18 represses noggin expression and is induced by calcineurin PMID: 15252029
    21. Cell proliferation in the Fgf18-/- lungs was also transiently reduced in embryonic lung alveoli. PMID: 15336546
    22. data identified fibroblast growth factor (FGF) 18 as a selective ligand for fibroblast growth factor receptor 3(FGFR3) in limb bud mesenchymal cells, which suppressed proliferation and promoted their differentiation and production of cartilage matrix PMID: 15781473
    23. These findings support a model in which FGF18 regulates skeletal vascularization and subsequent recruitment of osteoblasts/osteoclasts through regulation of early stages of chondrogenesis and VEGF expression. PMID: 17014841
    24. FGF18 may play a prominent role in chondrogenesis and osteogenesis during skeletal development and growth (review) PMID: 17128416
    25. Fgf18 may function as an essential component of the Wnt-dependent steps of osteoblastogenesis that are genetically downstream of Runx2. PMID: 17158875
    26. promotion of osteoblast differentiation by Glis3 involves increased expression of FGF18 PMID: 17488195
    27. Data indicate that FGF18 and FGFR3 are involved, possibly as partners, in the control of intestinal precursor cell proliferation. PMID: 18286540
    28. FGF18 provided both directional and proliferative cues to chondrocytes in the developing upper respiratory tract. PMID: 19358209

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Heparin-binding growth factors family
  • 数据库链接：

    KEGG: mmu:14172

    STRING: 10090.ENSMUSP00000020507

    UniGene: Mm.339812