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  4. Recombinant Mouse F-box only protein 6 (Fbxo6)

Recombinant Mouse F-box only protein 6 (Fbxo6)

  • 货号：
    CSB-YP870789MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP870789MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP870789MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP870789MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP870789MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Fbxo6; Fbs2; Fbxo6bF-box only protein 6; F-box only protein 6b; F-box protein that recognizes sugar chains 2; F-box/G-domain protein 2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-295
  • 氨基酸序列
    MVHINELPEN ILLELFIHIP APQLLRNCRL VCRLWRDLID VVSLWKRKSL REGFFTKDRC EPVEDWKVFY ILCSLQRNLL RNPCAEENLS SWRIDSNGGD RWKVETLPGS CGTSFPDNKV KKYFVTSFEM CLKSQMVDLK AEGYCEELMD TFRPDIVVKD WVAPRADCGC TYQLRVQLAS ADYIVLASFE PPPVTFQQWN DAKWQEISHT FSDYPPGVRH ILFQHGGQDT QFWKGWYGPR VTNSSIIISH RTAKNPPPAR TLPEETVVIG RRRRASDSNT HEGFFWQGLW QRLRR
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in DNA damage response by specifically recognizing activated CHEK1 (phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. Ubiquitination of CHEK1 is required to insure that activated CHEK1 does not accumulate as cells progress through S phase, or when replication forks encounter transient impediments during normal DNA replication. Involved in endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans.
  • 基因功能参考文献：
    1. Fbs2 is a novel member of F-box protein family that recognizes N-glycans and plays a role in ERAD PMID: 12939278
  • 亚细胞定位：
    Cytoplasm.
  • 组织特异性：
    Present in liver and kidney (at protein level). Widely expressed.
  • 数据库链接：

    KEGG: mmu:50762

    STRING: 10090.ENSMUSP00000030858

    UniGene: Mm.27445