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  4. Recombinant Mouse F-box only protein 25 (Fbxo25)

Recombinant Mouse F-box only protein 25 (Fbxo25)

  • 中文名称：
    小鼠Fbxo25重组蛋白
  • 货号：
    CSB-YP863504MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Fbxo25重组蛋白
  • 货号：
    CSB-EP863504MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Fbxo25重组蛋白
  • 货号：
    CSB-EP863504MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Fbxo25重组蛋白
  • 货号：
    CSB-BP863504MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Fbxo25重组蛋白
  • 货号：
    CSB-MP863504MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Fbxo25; Fbx25F-box only protein 25
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-357
  • 氨基酸序列
    MPFLGQDWRS PGWSWIKTED GWKRCDPCSH ELRSEDSQYT INHSIILNSG EEEIFNNECE YAAKKRKKEH FGNDTAAHSF YREKWIYVHK ESTKERHGYC TLGEAFNRLD FSSAIQDIRR FTYVVKLLQL IAKSQLTSLS GVAQKNYFNI LDKIVQKVLD DHQNPRLIKG LLQDLSSTLG ILVRGVGKSV LVGNINIWIC RLETVLSWQQ QLQNLQVTKQ VNTGLTLSDL PLHMLNNILY RFSDGWDIVT LGQVTPTLYM LSEDRRLWKR LCQYHFAEQQ FCRHLILSEK GHIEWKLMYF TLQKYYPTKE QYGDTLHFCR HCSILFWKDS GHPCTAADPD SCFTPVSPEH FIDLFKF
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. May play a role in accumulation of expanded polyglutamine (polyQ) protein huntingtin (HTT).
  • 基因功能参考文献：
    1. Altogether, Fbxo25 acts as an ubiquitin E3 ligase to target cardiac transcription factors including Nkx2-5, Isl1, and Hand1, indicating that cardiac protein homeostasis through Fbxo25 has a pivotal impact on cardiac development. PMID: 21596019
    2. mFbx25 shows predominantly neuronal expression and in adult mouse brain, expression is confined to the hippocampus, the cerebral cortex and the Purkinje cell layer PMID: 16278047
    3. FBXO25 is a novel F-box protein analogous to atrogin-1, which is not involved in muscle atrophy. PMID: 16714087
    4. The cellular distribution of FBXO25 and its colocalization with some nuclear proteins is investigated by using immunochemical and biochemical approaches. PMID: 18287534
  • 亚细胞定位：
    Nucleus. Note=In the nucleus, associates with a specific and novel subnuclear dot-like structure. Colocalized with SKP1.
  • 组织特异性：
    Expressed in all tissues tested, except striated muscle (at protein level). Expressed predominantly in the cerebral cortex, the hippocampus and the Purkinje cell layer of the brain. Intestine and kidney show also significant levels.
  • 数据库链接：

    KEGG: mmu:66822

    STRING: 10090.ENSMUSP00000039544

    UniGene: Mm.37950