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  4. Recombinant Mouse Ephrin type-B receptor 1 (Ephb1), partial

Recombinant Mouse Ephrin type-B receptor 1 (Ephb1), partial

  • 中文名称：
    小鼠Ephb1重组蛋白
  • 货号：
    CSB-YP806509MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Ephb1重组蛋白
  • 货号：
    CSB-EP806509MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Ephb1重组蛋白
  • 货号：
    CSB-EP806509MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Ephb1重组蛋白
  • 货号：
    CSB-BP806509MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Ephb1重组蛋白
  • 货号：
    CSB-MP806509MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Ephb1
  • Uniprot No.：
  • 别名：
    Ephb1Ephrin type-B receptor 1; EC 2.7.10.1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires repulsive interaction with EFNB2. In the adult nervous system together with EFNB3, regulates chemotaxis, proliferation and polarity of the hippocampus neural progenitors. In addition to its role in axon guidance plays also an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formation. May also regulate angiogenesis. More generally, may play a role in targeted cell migration and adhesion. Upon activation by EFNB1 and probably other ephrin-B ligands activates the MAPK/ERK and the JNK signaling cascades to regulate cell migration and adhesion respectively. Involved in the maintenance of the pool of satellite cells (muscle stem cells) by promoting their self-renewal and reducing their activation and differentiation.
  • 基因功能参考文献：
    1. EphA2 mAb treatment could partially inhibit LPSinduced inactivation of EphBEphrin B3 signalling, while Ephrin B3 overexpression could abrogate LPSinduced activation of EphA2Ephrin A1 signalling. EphB1/Ephrin B3 signalling may antagonise the EphA2/Ephrin A1dependent pathway following LPS treatment PMID: 29901151
    2. ephrin type-B receptor 1 (EphB1) is upregulated in injured motor neurons, which in turn can activate astrocytes through ephrin-B1-mediated stimulation of signal transducer and activator of transcription-3 (STAT3) PMID: 29079839
    3. SUMOylation of EphB1 repressed activation of its downstream signaling molecule PKC-gamma, and consequently inhibited neuroblastoma tumorigenesis. PMID: 29550816
    4. Findings suggest that a combination of forward and reverse EphB1/2 receptor-mediated signaling contribute to posterior branch of the anterior commissure and corpus callosum axon guidance PMID: 26148571
    5. During re-epithelialization ephrin-B1 and its receptor EphB2 are both upregulated in vivo, just for the duration of repair. PMID: 26549443
    6. In a genetic medulloblastoma model, EphB1 knockout resulted in a significant delay in tumor recurrence following irradiation compared to EphB1-expressing control tumors. PMID: 25879388
    7. EphB1 expression is activated in the spinal cord in a bone cancer model. PMID: 23973554
    8. The studies introduce EphB1 as a new venous-restricted marker in a tissue-specific and time-dependent manner. PMID: 23649798
    9. Reelin induces EphB activation. PMID: 23318582
    10. role of EphB1 receptors signalling in models of inflammatory and neuropathic pain PMID: 23341972
    11. ephrin B1 has a role in maintaining the structural integrity of the developing cortex and maintaining apical adhesion of neural progenitors PMID: 23578932
    12. PI3K and PI3K crosstalk to ERK signaling contributed to modulation of spinal nociceptive information related to ephrinBs/EphBs. PMID: 22879882
    13. Data show that EphB1, not Ephb2, is the preferred receptor of ephrin-B2 and ephrin-B1 in mediating axon guidance at the optic chiasm despite the coexpression of EphB2 in the same ipsilaterally projecting retinal axons. PMID: 22103419
    14. Eph receptor signalling mediates the repression of spine proliferation induced by climbing fibre activity in Purkinje cell proximal dendrit PMID: 21559471
    15. EphB2 and EphB1 signallings are key mediators of ventral-temporal retinal ganglion cell axon retinocollicular mapping. PMID: 21847105
    16. Result implies a NC-derived cell-specific role of EphB-ephrin-B2 interactions in the collective migration of the thymic rudiment during organogenesis. PMID: 20616004
    17. These findings implicate EPHB1 for targeting of eye-specific zones that are independent of midline guidance cues and that function in concert with correlated retinal activity to sculpt retinogeniculate projections. PMID: 19940181
    18. EphB1 and EphB3 receptor knockout mice exhibited significantly diminished DPOAE levels as compared to wild-type littermates, indicating that these specific Eph receptors are necessary for normal cochlear function. PMID: 12684184
    19. ligand-activated EphB1 forms a signaling complex with Nck, paxillin, and focal adhesion kinase and induces tyrosine phosphorylation of paxillin in a c-Src-dependent manner to promote cell migration PMID: 15107421
    20. Activation of EphB1 receptors by appropriate concentrations of its ligand ephrinB2 might contribute to the acquisition of a dopaminergic fate in developing midbrain ventral neurones. PMID: 15663472
    21. the ephrin-B1/EphB system may participate in the lesion-induced plasticity processes in the adult mouse hippocampus PMID: 15932593
    22. EFNB1 and EFNB1 receptors are critical in thymocyte development PMID: 16476740
    23. These results suggest that EphB1 is necessary for the proper formation of SNr, and that neuronal loss in SNr is associated with altered locomotor functions. PMID: 17561836
    24. results therefore support a role for Eph/ephrinB in the processes of development and selection of thymocytes as well as in the establishment of the three-dimensional organization of TEC PMID: 17668899
    25. The ubiquitin ligase Cbl induces the ubiquitination and lysosomal degradation of activated EphB1, a process requiring EphB1 and Src kinase activity. PMID: 18034775
    26. This transcription factor regulates the expression of EphB1 in RGCs and also suggest the existence of an additional EphB1-independent pathway controlled by Zic2 that contributes to retinal axon divergence at the midline. PMID: 18417618
    27. EphB1 expression on retinal ganglion cell growth cones mediates the avoidance of the midline cue ephrinB2. PMID: 18524895
    28. EphrinBs may act as a prominent contributor to peripheral sensitization, and demonstrate that activation of peripheral ephrinBs/EphBs system induces hyperalgesia through a MAPKs-mediated mechanism. PMID: 18706764
    29. EphB1 receptor is necessary for development of neuropathic pain and physical dependence on morp PMID: 19025592
    30. Ectopic EphB1 expression can redirect retinal ganglion cells with a normally crossed projection to an ipsilateral trajectory. PMID: 19295152
    31. EphB1 receptor is essential for development of long-term potentiation PMID: 19523204
    32. One of several receptor proteins that serves as a guidance receptor for neuronal connectivity and axon guidance cues. PMID: 11532925

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein. Early endosome membrane. Cell projection, dendrite.
  • 蛋白家族：
    Protein kinase superfamily, Tyr protein kinase family, Ephrin receptor subfamily
  • 组织特异性：
    Expressed in neural stem and progenitor cells in the dentate gyrus. Expressed in myogenic progenitor cells.
  • 数据库链接：

    KEGG: mmu:270190

    STRING: 10090.ENSMUSP00000035129

    UniGene: Mm.22897