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  4. Recombinant Mouse Endothelial protein C receptor (Procr), partial

Recombinant Mouse Endothelial protein C receptor (Procr), partial

  • 货号：
    CSB-YP717564MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP717564MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP717564MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP717564MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP717564MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Procr; EpcrEndothelial protein C receptor; Activated protein C receptor; APC receptor; Centrocyclin; Centrosomal protein CCD41; Endothelial cell protein C receptor; CD antigen CD201
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Binds activated protein C. Enhances protein C activation by the thrombin-thrombomodulin complex; plays a role in the protein C pathway controlling blood coagulation.
  • 基因功能参考文献：
    1. Leu8 is crucial for FVIIa-EPCR binding; this study characterizes its interaction in vivo in mice PMID: 28035745
    2. PROCR thus does not globally inhibit Th17 responses but could be targeted to selectively inhibit proinflammatory Th17 cells. PMID: 27670590
    3. Thrombin-PAR1 signaling, via nitric oxide and EPCR, promotes hematopoietic stem cell (HSC) mobilization. aPC-EPCR-PAR1 signaling promotes HSC retention in bone marrow. PMID: 26457757
    4. HSCs appear to maintain expression of CD201 after hematopoietic injury when Kit expression is downregulated. PMID: 25892186
    5. The protein C receptor (ProcR; EPCR) was required for the normal in vivo and in vitro induction of lipopolysaccharide (LPS)-regulated gene expression. PMID: 25733582
    6. Data indicate that endothelial protein C receptor (EPCR) binding enhances FVIIa hemostatic activity in vivo. PMID: 24957146
    7. knock-outs display diminished inflammatory immunity, enhanced blood coagulation as well as reduced bacterial growth in pneumococcal pneumonia and sepsis PMID: 24401906
    8. protein C receptor (Procr), a novel Wnt target in the mammary gland, marks a unique population of multipotent mouse mammary stem cells PMID: 25327250
    9. FVIIa binding to EPCR leads to a barrier protective effect in vivo PMID: 24977291
    10. Piperlonguminine might have potential as an anti-sEPCR shedding reagent against sepsis-mediated EPCR shedding. PMID: 24127121
    11. FVIIa binding to EPCR on the endothelium facilitates the transport of FVIIa from circulation to extravascular tissues where TF resides PMID: 22950420
    12. mineralocorticoid receptor activation has a role in enhancing endothelial protein C receptor and decreases vascular thrombosis in mice PMID: 24451386
    13. Endothelial protease nexin-1 is a novel regulator of A disintegrin and metalloproteinase 17 maturation and endothelial protein C receptor shedding via furin inhibition. PMID: 23661674
    14. Study demonstrates an important protective role for EPCR in vivo against vascular leakage during inflammation and suggests that EPCR-dependent vascular protection is organ-specific. PMID: 23393392
    15. FFAs inhibit TM-EPCR-Protein C system in endothelial cells through activating JNK signaling, which may be a mechanism for the prothrombotic state in metabolic syndrome. PMID: 22903729
    16. data indicate that it is possible to overexpress EPCR at a sufficient level to provide protection against transplant-related thrombotic and inflammatory injury PMID: 22681753
    17. Letter: Endothelial cell protein C receptor does not appear to play a significant role in human factor VIIa clearance from plasma. PMID: 22372829
    18. Murine FVIIa binds poorly to murine EPCR. PMID: 22370814
    19. EPCR interacts with the ternary TF coagulation initiation complex to enable PAR1,2 signaling. PMID: 21149441
    20. Blocking accelerates thrombus development PMID: 20352165
    21. EPCR(+) hematopoietic stem cells resided in the perisinusoidal niche in mouse fetal liver. PMID: 20442369
    22. EPCR was detected in the trophoblast. In the embryo, EPCR was weakly detected in aortic endothelial cells and thereafter, levels increased in certain large blood vessel endothelial cells. PMID: 12195698
    23. essential for normal embryonic development; plays a key role in preventing thrombosis at the maternal-embryonic interface PMID: 12218060
    24. minimal levels of EPCR are able to support male and female virility, as well as embryonic development, birth, and survival to adulthood. PMID: 12353077
    25. extraembryonic EPCR expression is critical for embryo development PMID: 15956290
    26. mEPCR, but not physiologically elevated sEPCR, regulated protein C activation. Procr heterozygosity results in a mild increase of thrombosis tendency and little influence on the response to endotoxin. PMID: 17023579
    27. activated protein C and its variants with reduced anticoagulant activity cross the blood-brain barrier via endothelial protein C receptor-mediated saturable transport PMID: 18841163
    28. expressed the extracellular region of the murine EPCR in a yeast expression system and obtained a colony of Pichia pastoris that produce high amounts of recombinant extracellular murine EPCR, which we purified by liquid chromatography to homogeneity PMID: 19041722
    29. APC molecular species with potent antithrombotic activity, but without robust cytoprotective activity, are not sufficient to reduce mortality in endotoxemia PMID: 19244160
    30. activated PC is barrier-protective in ventilator lung injury and EPCR is a critical participant in APC-mediated protection PMID: 19363121
    31. endogenous APC limits cancer cell extravasation because of S(1)P(1)-mediated VE-cadherin-dependent vascular barrier enhancement PMID: 19571314

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  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 组织特异性：
    Expressed in endothelial cells.
  • 数据库链接：

    KEGG: mmu:19124

    STRING: 10090.ENSMUSP00000029140

    UniGene: Mm.3243