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  4. Recombinant Mouse Endothelial cell-specific chemotaxis regulator (Ecscr), partial

Recombinant Mouse Endothelial cell-specific chemotaxis regulator (Ecscr), partial

  • 中文名称：
    小鼠Ecscr重组蛋白
  • 货号：
    CSB-YP007385MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Ecscr重组蛋白
  • 货号：
    CSB-EP007385MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Ecscr重组蛋白
  • 货号：
    CSB-EP007385MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Ecscr重组蛋白
  • 货号：
    CSB-BP007385MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Ecscr重组蛋白
  • 货号：
    CSB-MP007385MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Ecscr
  • Uniprot No.：
  • 别名：
    Ecscr; Ecsm2Endothelial cell-specific chemotaxis regulator; Apoptosis regulator through modulating IAP expression; ARIA; Endothelial cell-specific molecule 2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Regulates endothelial chemotaxis and tube formation. Has a role in angiogenesis and apoptosis via modulation of the actin cytoskeleton and facilitation of proteasomal degradation of the apoptosis inhibitors BIRC3/IAP1 and BIRC2/IAP2.
  • 基因功能参考文献：
    1. these results suggest that ECSCR plays a critical function in regulating lipolysis in white adipose tissue. PMID: 26692198
    2. two mouse ECSCR splicing variants/isoform precursors exist and are differentially expressed in a variety of tissue types and likely involved in modulation of vascular Endothelial cell migration. PMID: 22606020
    3. These studies, revealed a previously undescribed mode of manipulating cardiac PI3K/Akt signaling by ARIA, thus identifying it as an attractive new target for the prevention of stress-induced myocardial dysfunction. PMID: 24338479
    4. Inactivation of Ecscr enhances insulin sensitivity and may represent a new therapeutic strategy for treating metabolic syndrome. PMID: 24022200
    5. ARIA was expressed in blood vessels during mouse embryogenesis, as well as in endothelial cells both in vitro and in vivo. PMID: 19416853

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein. Cytoplasm.
  • 蛋白家族：
    ECSCR family
  • 组织特异性：
    Expressed in all tissues examined, highest expression was observed in lung and spleen endothelial cells.
  • 数据库链接：

    KEGG: mmu:68545

    UniGene: Mm.329362