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  4. Recombinant Mouse Endoglin (Eng), partial

Recombinant Mouse Endoglin (Eng), partial

  • 货号：
    CSB-YP007667MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP007667MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP007667MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP007667MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP007667MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Eng; EdgEndoglin; Cell surface MJ7/18 antigen; CD antigen CD105
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis. Required for normal structure and integrity of adult vasculature. Regulates the migration of vascular endothelial cells. Required for normal extraembryonic angiogenesis and for embryonic heart development. May regulate endothelial cell shape changes in response to blood flow, which drive vascular remodeling and establishment of normal vascular morphology during angiogenesis. May play a role in the binding of endothelial cells to integrins. Acts as TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade that ultimately leads to the activation of SMAD transcription factors. Required for GDF2/BMP9 signaling through SMAD1 in endothelial cells and modulates TGFB1 signaling through SMAD3.
  • 基因功能参考文献：
    1. Transplantation of mesenchymal stem cells, when combined with endothelial progenitor cells, accelerate muscle recovery in a mouse model of hind limb ischemia, through an endoglin-dependent mechanism. PMID: 28771278
    2. we cannot rule out a possibility that a long-term chronic exposure (9 months and more) to soluble endoglin alone or combined with other cardiovascular risk factors may contribute to alterations of heart function and structure in Sol-Eng+ mice, which is the topic in our lab in ongoing experiments PMID: 28382387
    3. Data show that concomitant activin receptor-like kinase 1 (Acvrl1) and endoglin (Eng) deficiency synergistically decreases pancreatic neuroendocrine tumor volume. PMID: 27741515
    4. Endoglin is necessary for the pro-angiogenic properties of the cardiosphere-derived cells secretome. PMID: 28494939
    5. results suggest that soluble endoglin modulates inflammatory-related diseases and open new perspectives leading to the development of novel and targeted approaches for the prevention and treatment of cardiovascular diseases PMID: 29145462
    6. Endoglin controls blood vessel diameter through endothelial cell shape changes in response to haemodynamic cues. PMID: 28530658
    7. Endoglin prevents vascular malformation by regulating flow-induced cell migration and specification through VEGFR2 signalling. PMID: 28530660
    8. Identification of novel regulators of developmental hematopoiesis using Endoglin regulatory elements as molecular probes PMID: 27554085
    9. Endoglin has an important role in VSMC recruitment and blood vessel maturation during angiogenesis. PMID: 28450296
    10. the TGFbeta1 coreceptor Eng selectively regulates expression of multiple transient receptor potential channels in the setting of left or right ventricular pressure overload PMID: 27614169
    11. Endothelial cell-specific endoglin expression in islets of Langerhans is sensitive to VEGF and plays partial roles in driving islet vascular development, however such regulation appears to be distinct to mechanisms required to modulate islet viability and size. PMID: 27456002
    12. Study provides evidence that the expression of endoglin is required for the establishment of uterine receptivity and the decidualization process, which mediate embryo adhesion or the attachment reaction. PMID: 26802878
    13. The changes in CD90 and CD105 expression in the testis and ovary of mice are reported. PMID: 26679159
    14. the altered immune activity of endoglin deficient macrophages could help to explain the higher rate of infectious diseases seen in HHT1 patients. PMID: 27010826
    15. These results demonstrate a requirement for endoglin in descendants of Pax3-expressing vascular cell precursors. PMID: 26481065
    16. The similarities in Eng-/- and Mlc2a-/- embryos suggest that Eng-/- mice may suffer from a primary heart developmental defect and secondary defects in vessel patterning. PMID: 26340748
    17. results of our study provide evidence of endoglin as a valid target for cancer therapy and support further development of plasmid shRNA delivery, which have prolonged antitumor effect, especially in combined schedules PMID: 25619888
    18. ENG deficiency leads to EC hyperpermeability through constitutive activation of RhoA and destabilization of endothelial barrier function. PMID: 25972355
    19. endoglin is not localized with cell adhesion molecules involved in atherosclerosis, suggesting it might not participate in leukocyte accumulation in aorta of apoE-deficient mice during atherogenesis PMID: 25208891
    20. Deficiency of MKP5 resulted in increased inflammatory activation in macrophages. These findings thus demonstrate that MKP5 critically controls inflammation in white adipose tissue and the development of metabolic disorders PMID: 25931117
    21. activin A (INHBA gene), a TGF-beta superfamily member involved in macrophage polarization, was distinctly affected in each endoglin transfectant, and may contribute to the regulated expression of integrins PMID: 25216259
    22. The findings suggest that endoglin is required for TGF-beta superfamily mediated resolution of inflammation and fully functional myeloid cells. PMID: 25114380
    23. Endoglin modulates intestinal angiogenic and inflammatory responses in colitis. PMID: 24510304
    24. Data demonstrate that ENG is required for efficient VEGF-induced angiogenesis. PMID: 24489709
    25. Taken together, we show that not only kidney morphology, but also kidney function is improved after irradiation in Eng(+/-) compared to Eng(+/+) mice. PMID: 23849167
    26. the mechanisms responsible for the angiogenic imbalance and the response to anti-VEGF therapy differ between Eng and Alk1 heterozygous mice and raise the need for systemic monitoring of anti-angiogenic therapy effects in HHT patients. PMID: 24061911
    27. Endoglin deficiency impairs brain injury recovery. PMID: 24876084
    28. CD105- mASCs had greater capacity to differentiate into adipocytes and osteocytes compared to CD105+ ASCs and were better at inhibiting T cell proliferation in vitro. PMID: 24124603
    29. The hematopoietic and endothelial progenitors can be distinguished by the levels of endoglin in developing yolk sacs. PMID: 23712751
    30. These results demonstrate an important involvement of Eng in wound healing that is associated with NO bioavailability. PMID: 23765132
    31. these results underscore the importance of endoglin in both canonical and non-canonical TGFbeta signaling pathways modulating both the activation and quiescence of the endothelium during angiogenesis. PMID: 23418351
    32. the accessory TGF-beta-receptor endoglin, which is endogenously expressed at very low levels, has a differential effect on signalling of these cells when transiently overexpressed. PMID: 23437087
    33. Thus, endoglin haploinsufficiency seems to promote fibroblast accumulation during wound healing through the activation of the PI3K/Akt pathway. PMID: 23349951
    34. Endoglin promotes kidney inflammation after irradiation by regulating macrophage infiltration and interleukin production, thereby promoting pathogenic changes after radiation exposure. PMID: 23022174
    35. Heterozygous deficiency of endoglin decreases insulin and hepatic triglyceride levels during high fat diet. PMID: 23336009
    36. toxicarioside A suppresses tumor growth through inhibition of endoglin-related tumor angiogenesis, which involves in the endoglin/TGF-beta signal pathway PMID: 23209720
    37. tumors deprived of endoglin exhibited a delayed onset of resistance to anti-VEGF (vascular endothelial growth factor) agents, illustrating the therapeutic utility of combinatorial targeting of multiple angiogenic pathways for the treatment of cancer PMID: 23401487
    38. These results suggest a regulatory role for endoglin in transendothelial leukocyte trafficking. PMID: 23074273
    39. Endoglin contributes to both shear induced collateral artery growth and to ischaemia induced angiogenesis, whereas ALK1 is only involved in ischaemia induced angiogenesis. PMID: 22436015
    40. These studies provide a clue to the involvement of the LXR pathway in soluble Eng release and its pathogenic role in vascular disorders such as preeclampsia. PMID: 23110859
    41. CD105 expression level defines a hierarchy among aortic hematopoietic cells allowing purification of clonogenic versus more immature hematopoietic progenitors. PMID: 22271899
    42. Deletion of Eng induces more severe cerebrovascular dysplasia per copy than that of Alk1 upon VEGF stimulation. PMID: 22571958
    43. our data suggest a mechanistic model whereby brain endothelial cells in remodeling arterial vessels downregulate CD105 expression, which alters TGF-beta1 signaling, to promote a switch in beta1 integrins and arteriogenic remodeling PMID: 22739620
    44. Eng modulates the hematopoietic transcriptional network, most likely through regulation of BMP4 signaling. PMID: 22728030
    45. Endoglin (Eng), a receptor for the TGF-beta superfamily, identifies all cells with hematopoietic fate in the early embryo. PMID: 22535663
    46. Eng mRNA was up-regulated in Ba/F3 cell lines stably expressing various oncogenic Kit mutations. This effect appeared to be independent of Kit activation. PMID: 21435173
    47. We propose that endoglin regulates primitive hematopoiesis by modulating the activity of the Smad1/5 signaling pathway in early stages of development PMID: 21602526
    48. Endoglin regulates cancer-stromal cell interactions in prostate tumors PMID: 21444673
    49. Higher VEGF levels and increased vascular permeability in the distal colon may predispose Eng(+/-) mice to progress to chronic and persistent bowel inflammation, associated with pathological angiogenesis. PMID: 20848471
    50. The ability to interfere with the expression and oncogenic potential of H-Ras provides a new face of the suppressor role exhibited by endoglin in H-Ras-driven carcinogenesis. PMID: 20884686

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  • 亚细胞定位：
    Cell membrane; Single-pass type I membrane protein.
  • 组织特异性：
    Detected on blood vessels (at protein level). Detected on adult pulmonary artery, capillaries supporting the heart muscle and lung alveolar capillary endothelial cells. Endoglin is restricted to endothelial cells in all tissues except bone marrow and is a
  • 数据库链接：

    KEGG: mmu:13805

    STRING: 10090.ENSMUSP00000009705

    UniGene: Mm.225297