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  4. Recombinant Mouse ETS-related transcription factor Elf-3 (Elf3)

Recombinant Mouse ETS-related transcription factor Elf-3 (Elf3)

  • 货号：
    CSB-YP666275MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP666275MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP666275MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP666275MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP666275MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Elf3; Ert; Esx; JenETS-related transcription factor Elf-3; E74-like factor 3; Epithelial-restricted with serine box; Epithelium-restricted Ets protein ESX; Epithelium-specific Ets transcription factor 1; ESE-1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-391
  • 氨基酸序列
    MAATCEISNV FSNYFNAMYS SEDPTLAPAP PTTFGTEDLV LTLNNQQMTL EGPGPQTRSQ RDRTDPLAVL HLAEKASWTS ERPQFWSKTQ VLEWISYQVE KNKYDASSID FSRCDMDGAT LCSCALEELR LVFGPLGDQL HAQLRDLTSN SSDELSWIIE LLEKDGMSFQ ESLGDSGPFD QGSPFAQELL DDGRQASPYY CSTYGPGAPS PGSSDVSTAR TATPQSSHAS DSGGSDVDLD LTESKVFPRD GFPDYKKGEP KHGKRKRGRP RKLSKEYWDC LEGKKSKHAP RGTHLWEFIR DILIHPELNE GLMKWENRHE GVFKFLRSEA VAQLWGQKKK NSNMTYEKLS RAMRYYYKRE ILERVDGRRL VYKFGKNSSG WKEEEVGESR N
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcriptional activator that binds and transactivates ETS sequences containing the consensus nucleotide core sequence GGA[AT]. Acts synergistically with POU2F3 to transactivate the SPRR2A promoter and with RUNX1 to transactivate the ANGPT1 promoter. Also transactivates collagenase, CCL20, CLND7, FLG, KRT8, NOS2, PTGS2, SPRR2B, TGFBR2 and TGM3 promoters. Represses KRT4 promoter activity. Involved in mediating vascular inflammation. May play an important role in epithelial cell differentiation and tumorigenesis. May be a critical downstream effector of the ERBB2 signaling pathway. May be associated with mammary gland development and involution. Plays an important role in the regulation of transcription with TATA-less promoters in preimplantation embryos, which is essential in preimplantation development.
  • 基因功能参考文献：
    1. ELF3 controls LCN2 expression in cooperation with NFkappaB. PMID: 27222093
    2. a novel role for ELF3 as a procatabolic factor that may contribute to cartilage remodeling and degradation by regulating MMP13 gene transcription. PMID: 22158614
    3. A novel function of Elf3 is identified that defines allergic airway inflammation caused by the regulation of dendritic cell-driven T helper (Th)1 cell, Th2 cell, and Th17 cell differentiation. PMID: 21948981
    4. Elf3 plays an important role in the regulation of lung cell proliferation and differentiation during repair of the injured bronchiolar airway epithelium. PMID: 21709667
    5. ESE-1 is an Ang II-inducible transcription factor that plays an important counter-regulatory role in the setting of vascular inflammation and remodeling. PMID: 20689519
    6. Elf3 amino acid residues within the flanking region, including Trp361, are important for the structural integrity of the protein as well as for the Efl3 DNA binding and transactivation activity. PMID: 20079749
    7. Like other Ets-family members, Elf3 functions as a sequence-specific DNA-binding transcriptional factor PMID: 20054123
    8. Results reveal that Crif1 is a novel and essential transcriptional coactivator of Elf3 for the terminal differentiation of absorptive enterocytes. PMID: 19801644
    9. Evidence that mElf-3, a member of the Ets family, plays a key role in the activation of the mTbetaR-II promoter. PMID: 11893733
    10. ErbB2 activation of ESX gene expression PMID: 12032832
    11. Both proximal and distal regions that regulate Elf3 promoter activity were identified. PMID: 15556300
    12. Elf3 contains multiple NLS motifs, which may function cooperatively to effect efficient nuclear transport PMID: 16516205

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  • 亚细胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    ETS family
  • 组织特异性：
    Expressed in small intestine, colon, lung, kidney and uterus. Also expressed in the corneal epithelium and conjunctiva of the developing and adult eye. Not detected in liver, spleen, thymus, brain, heart, skeletal muscle or ovary.
  • 数据库链接：

    KEGG: mmu:13710

    STRING: 10090.ENSMUSP00000003135

    UniGene: Mm.441439