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  4. Recombinant Mouse Draxin

Recombinant Mouse Draxin

  • 货号：
    CSB-YP740756MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP740756MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP740756MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP740756MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP740756MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Draxin
  • Uniprot No.：
  • 别名：
    DraxinDraxin; Dorsal inhibitory axon guidance protein; Dorsal repulsive axon guidance protein; Neucrin
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    26-343
  • 氨基酸序列
    GTLAS GSSARNLPET HSHLPSSALW VSQASHHGRR GLGKKDRGPG RPSRAQEGAV VTATKQASQM TLGQPPAGLL QNKELLLGLT LPYPEKEARS PAWERVKKRG REHKRRRDRL RLHRGRAAIR GPSSLMKKVE PSEDRMLEGT MEESSTSLAP TMFFLTMTDG ATPTTEESRI LPVTSLRPQT QPRSDGEVMP TLDMALFDWT DYEDLKPEVW PSAKKKEKHW SHFTSDGNET SPAEGDPCDH HQDCLPGTCC DLREHLCTPH NRGLNNKCFD DCMCMEGLRC YAKFHRNRRV TRRKGRCVEP ETANGDQGSF INI
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway.
  • 基因功能参考文献：
    1. draxin regulates the proapoptotic activity of DCC in the subgranular zone by directly interacting with the DCC dependence receptor and not by preventing the interaction between prosurvival Netrin-1 and DCC. PMID: 29339781
    2. draxin is a key molecule in the regulation of mossy fiber projections. PMID: 29634927
    3. draxin may regulate mouse trunk neural crest cell migration. PMID: 27649978
    4. These results suggest that draxin from neocortical neurons controls thalamocortical projections into the neocortex, and that this effect is mediated through the DCC and Neo1 receptors. PMID: 26659141
    5. Study elucidates for the first time, molecular events in draxin repulsion and links draxin and DCC to MAP1B to axon guidance cue signaling. PMID: 25775433
    6. The combinatorial guidance activities of draxin and Tsukushi are essential for forebrain commissure formation PMID: 23206892
    7. Draxin interacts with subnanomolar affinity to the netrin receptor DCC, in a region of DCC distinct from its netrin-binding domain. PMID: 21957262
    8. These results suggest that draxin functions as an inhibitory guidance cue for olfactory bulb axons and indicate its contribution to the formation of the lateral olfactory tract. PMID: 20621059
    9. This study found that draxin, a repulsive axon guidance cue, was widely expressed in the developing hippocampus and draxin deficient mice possessed a smaller hippocampus. PMID: 19808066
    10. draxin knockout mice showed defasciculation of spinal cord commissural axons & absence of all forebrain commissures; draxin is a previously unknown chemorepulsive axon guidance molecule required for the development of spinal cord & forebrain commissures PMID: 19150847
    11. Neucrin is a unique secreted Wnt antagonist that is predominantly expressed in developing neural tissues. PMID: 19857465

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  • 亚细胞定位：
    Secreted.
  • 蛋白家族：
    Draxin family
  • 组织特异性：
    In embryonic brain, strong expression in the olfactory bulb, anterior olfactory nucleus, neocortex, piriform cortex, glial wedge, midline zipper glia, indusium griseum and the area surrounding the anterior commissure (AC) but not on AC axons (at protein l
  • 数据库链接：

    KEGG: mmu:70433

    STRING: 10090.ENSMUSP00000030862

    UniGene: Mm.275288