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  4. Recombinant Mouse Dorsal root ganglia homeobox protein (Drgx)

Recombinant Mouse Dorsal root ganglia homeobox protein (Drgx)

  • 货号：
    CSB-YP804425MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP804425MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP804425MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP804425MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP804425MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Drgx
  • Uniprot No.：
  • 别名：
    Drgx; Drg11; Prrxl1Dorsal root ganglia homeobox protein; Dorsal root ganglion 11; Homeobox protein DRG11; Paired-related homeobox protein-like 1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-263
  • 氨基酸序列
    MFYFHCPPQL EGTAPFGNHS TGDFDDGFLR RKQRRNRTTF TLQQLEALEA VFAQTHYPDV FTREELAMKI NLTEARVQVW FQNRRAKWRK TERGASDQEP GAKEPMAEVT PPPVRNINSP PPGDQTRSKK EALEAQQSLG RTVGPTGPFF PSCLPGTLLN TATYAQALSH VASLKGGPLC SCCVPDPMGL SFLPTYGCQS NRTASVAALR MKAREHSEAV LQSANLLPST SSSPGPASKQ APPEGSQDKT SPTKEQSEGE KSV
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription factor required for the formation of correct projections from nociceptive sensory neurons to the dorsal horn of the spinal cord and normal perception of pain.
  • 基因功能参考文献：
    1. The findings provide evidence for a putative novel role of PIN1 in the development of the nociceptive system and indicate phosphorylation-mediated conformational changes as a mechanism for regulating the PRRXL1 role in the process. PMID: 28049756
    2. The results of this study suggest that Prrxl1 knockout mouse model of congenital hypoalgesia may have an effect on brain plasticity that is the inverse of what is usually observed in animal models of chronic pain. PMID: 27168359
    3. The results of this study showed that Prrxl1(-/-) animal is a valuable model system for examining the genetic assembly and functional role of trigeminal lemniscal circuits in the normal control of eating in mammals. PMID: 26402339
    4. Tlx3 uses distinct mechanisms to tightly modulate Prrxl1 activity, either by controlling its transcriptional levels or by increasing Prrxl1 phosphorylation state. PMID: 25138281
    5. Prrxl1 uses distinct regulatory regions to repress its own expression in dorsal root ganglia and dorsal spinal cord. PMID: 25131932
    6. Data suggest phosphorylation at serine-119 is a determinant of Prrxl1 conformation/transcriptional activity in embryonic dorsal root ganglia and dorsal spinal cord nociceptive neurons and may regulate Prrxl1 during nociceptive system development. PMID: 24564673
    7. Prrxl1 transcription is regulated by three alternative promoters, which control the expression of three distinct Prrxl1 5'-UTR variants. PMID: 24214975
    8. Our present results point to a role for Prrxl1 in sensitization of nociceptive neurons upon inflammatory pain. PMID: 21094620
    9. Formation of whisker-related principal sensory nucleus-based lemniscal pathway requires Drg11. PMID: 12917357
    10. transcriptionally regulates DRAGON; coexpressed with DRAGON in embryonic dorsal root ganglion and spinal cord PMID: 14985445
    11. Our results demonstrate an essential role for Drg11 in the development of the mesencephalic trigeminal nucleus. PMID: 17482477
    12. DRG11 is required for the establishment of the first neuronal sensory relay along development PMID: 17676639
    13. Apoptotic cell death is not a sufficient cause of failed pattern formation in the PrV of the DRG11(-/-). PMID: 18385316
    14. the tissue-specific role of the Prrxl1 gene may be sustained by an accurate balance in the ratio between the amount of Prrxl1 and its OAR-lacking variant, Prrxl1-b, which may be critical during nociceptive circuit development PMID: 19598127

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  • 亚细胞定位：
    Nucleus.
  • 蛋白家族：
    Paired homeobox family
  • 组织特异性：
    Expressed in the dorsal horn of the spinal cord and dorsal root ganglia. Isoform 1 is higher expressed than isoform 2 both in the dorsal root ganglia and in the spinal cord. Isoform 2 is exclusively localized in neurons primarily involved in the processin
  • 数据库链接：

    KEGG: mmu:107751

    STRING: 10090.ENSMUSP00000064107

    UniGene: Mm.119274