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  4. Recombinant Mouse Dopamine beta-hydroxylase (Dbh), partial

Recombinant Mouse Dopamine beta-hydroxylase (Dbh), partial

  • 中文名称：
    Recombinant Mouse Dopamine beta-hydroxylase(Dbh),partial,Yeast
  • 货号：
    CSB-YP714478MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Dopamine beta-hydroxylase(Dbh),partial,Yeast
  • 货号：
    CSB-EP714478MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Dopamine beta-hydroxylase(Dbh),partial,Yeast
  • 货号：
    CSB-EP714478MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Dopamine beta-hydroxylase(Dbh),partial,Yeast
  • 货号：
    CSB-BP714478MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Dopamine beta-hydroxylase(Dbh),partial,Yeast
  • 货号：
    CSB-MP714478MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Dbh
  • Uniprot No.：
  • 别名：
    DbhDopamine beta-hydroxylase; EC 1.14.17.1; Dopamine beta-monooxygenase) [Cleaved into: Soluble dopamine beta-hydroxylase]
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Conversion of dopamine to noradrenaline.
  • 基因功能参考文献：
    1. In mice, hepatic Dbh mRNA levels correlated with cardiovascular risk phenotypes. PMID: 25326128
    2. Dbh-deficient mice exhibit shorter latencies to loss of righting reflex and longer durations of hypersensitivity to general anesthesia. PMID: 23042227
    3. our results suggest that DBH knockout mice have normal levels of dopamine 2 receptors in the high-affinity state and that additional mechanisms contribute to their behavioral sensitivity to psychostimulants PMID: 20336622
    4. These results strongly suggest that the norepinephrine defect in Mecp2(-/Y) mice is likely to result from deficient expression of not only tyrosine hydroxylase but also DBH without significant loss of catecholaminergic neurons in the locus coeruleus. PMID: 20193660
    5. Dbh-/- animals were hypersensitive to the behavioral effects of amphetamine. PMID: 12370425
    6. A mutation in the ATP7B copper transporter causes reduced levels of this enzyme and norepinephrine in the mouse adrenal gland. PMID: 12718440
    7. The response of mice deficient in this gene to cholecystokinin-8 induced satiety PMID: 12736175

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  • 亚细胞定位：
    [Soluble dopamine beta-hydroxylase]: Cytoplasmic vesicle, secretory vesicle lumen. Cytoplasmic vesicle, secretory vesicle, chromaffin granule lumen.; Cytoplasmic vesicle, secretory vesicle membrane; Single-pass type II membrane protein. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane; Single-pass type II membrane protein.
  • 蛋白家族：
    Copper type II ascorbate-dependent monooxygenase family
  • 组织特异性：
    Detected in adrenal gland secretory granules (at protein level). Detected in adrenal gland.
  • 数据库链接：

    KEGG: mmu:13166

    STRING: 10090.ENSMUSP00000000910

    UniGene: Mm.167781