Your Good Partner in Biology Research

  1. 首页
  2. 蛋白
  3. 重组蛋白
  4. Recombinant Mouse Dixin (Dixdc1)

Recombinant Mouse Dixin (Dixdc1)

  • 货号：
    CSB-YP770494MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP770494MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP770494MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP770494MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP770494MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Dixdc1
  • Uniprot No.：
  • 别名：
    Dixdc1; Ccd1; Kiaa1735Dixin; Coiled-coil protein DIX1; Coiled-coil-DIX1; DIX domain-containing protein 1
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-711
  • 氨基酸序列
    MLACLTRGNL LDVLQEGFNE QQLQAYVAWV NAQLKKRPSV KPVQDLRQDL RDGVILAYLI EIVGQLALDS DASVDERTDF FLLHSPFKAA GEKLTGVQLS PSNQQEMKSN VERVLQFVAS KKIRMHQTSA KDIVEGNLKS IMRLVLALAA HFKPGSSRTV SQGRDSKAPV QSHQPHCATA VAQGAAAALA DVCHDVSRSG RDVFRYRQRN ASVDGEIENP YWSVRALVQQ YEGQQKSPSE SSCSSLTSPS PIHSAKSESI ITQAEEKADF VIIPSEGIEN RTDEPDSPSS RDWRPGSRGT YLEATWEEQL LEQQEHLEKE MEEAKKMISG LQALLLNGSL PEDEQERPVA LCEPGVNPEE QLIIIRSRLD QSVEENQDLK KELLKCKQEA RNLQGIKDAL QQRLTQQDTS VLQLKQELLR ANMDKDELHN QNVDLQRKLE ERNRLLGEYK KELGQKDRLF QQQQAKLEEA LRKLSDASYQ QVDLERELEQ KDVLLAHCMK GETDEVTNYN SHSSQRNGFV LPVAGRGATT VTHRGPQTSD LQLVRDALRS LRNSFSGHDP QHHTIDSLEQ GISSLMERLH VVETQKKQER KVGGRSPRNQ ASSEYRASWP PNSTLPHSQS SPAVSSTCTK VLYFTDRSLT PFMVNIPKRL GEVTLKDFKA AIDREGNHRY HFKALDPEFG TVKEEVFHDD DAIPGWEGKI VAWVEEDHRE N
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Positive effector of the Wnt signaling pathway; activates WNT3A signaling via DVL2. Regulates JNK activation by AXIN1 and DVL2.
  • 基因功能参考文献：
    1. DIXDC1 is a regulator of cortical dendrite and synaptic development. PMID: 27829159
    2. Abnormal behavior in Dixdc1 mice could elucidate molecular pathophysiology involving Disc1 in major mental illnesses. PMID: 22832659
    3. crystals of the Ccd1 DIX domain belonged to space group P2(1)2(1)2(1), with unit-cell parameters a=72.9, b=75.7, c=125.6 A. An X-ray diffraction data set was collected at 3.0 A resolution PMID: 21795788
    4. a molecular mechanism for Ccd1-mediated Wnt activation in that Ccd1 converts latent polymeric Dvl to a biologically active oligomer(s). PMID: 21189423
    5. DIXDC1 encodes a novel protein with a myosine-tail homologous domain and C-terminal DIX domain PMID: 12792787
    6. mouse Ccd1 functions as a positive regulator of the Wnt/beta-catenin pathway. Furthermore, Ccd1 is highly expressed and co-localized with Wnt signaling molecules in the embryonic and adult brain. PMID: 15857680

    显示更多

    收起更多

  • 亚细胞定位：
    Cell junction, focal adhesion. Cytoplasm, cytoskeleton, stress fiber. Cytoplasm.
  • 蛋白家族：
    DIXDC1 family
  • 组织特异性：
    Abundantly expressed in brain and testis and to a lower extent in lung, kidney, colon, ovary and urinary bladder. Expressed in brain, liver, testis and spleen (at protein level). Expressed throughout the brain with strong expression in main and accessory
  • 数据库链接：

    KEGG: mmu:330938

    STRING: 10090.ENSMUSP00000034566

    UniGene: Mm.82598