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  4. Recombinant Mouse Disintegrin and metalloproteinase domain-containing protein 2 (Adam2), partial

Recombinant Mouse Disintegrin and metalloproteinase domain-containing protein 2 (Adam2), partial

  • 中文名称：
    Recombinant Mouse Disintegrin and metalloproteinase domain-containing protein 2(Adam2),partial,Yeast
  • 货号：
    CSB-YP733703MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Disintegrin and metalloproteinase domain-containing protein 2(Adam2),partial,Yeast
  • 货号：
    CSB-EP733703MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Disintegrin and metalloproteinase domain-containing protein 2(Adam2),partial,Yeast
  • 货号：
    CSB-EP733703MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Disintegrin and metalloproteinase domain-containing protein 2(Adam2),partial,Yeast
  • 货号：
    CSB-BP733703MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Disintegrin and metalloproteinase domain-containing protein 2(Adam2),partial,Yeast
  • 货号：
    CSB-MP733703MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Adam2
  • Uniprot No.：
  • 别名：
    Adam2; FtnbDisintegrin and metalloproteinase domain-containing protein 2; ADAM 2; Fertilin subunit beta; PH-30; PH30; PH30-beta
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Sperm surface membrane protein that may be involved in sperm-egg plasma membrane adhesion and fusion during fertilization. Could have a direct role in sperm-zona binding or migration of sperm from the uterus into the oviduct. Interactions with egg membrane could be mediated via binding between its disintegrin-like domain to one or more integrins receptors on the egg. This is a non catalytic metalloprotease-like protein.
  • 基因功能参考文献：
    1. Characterization of promoter and repressor regions that regulate the transcription of the mouse Adam2 gene. PMID: 23065232
    2. data indicate that ITGA9-ITGB7 functions as an ADAM binding partner in certain cellular contexts, with implications for mammalian fertilization and integrin function PMID: 21060781
    3. we report that Adam2 and Adam3 knockout sperm have severely impaired sperm aggregation and that this defect is not restored over time during in vitro cultivation. PMID: 20400072
    4. role of CD9 in the strengthening of fertilin beta-mediated cell adhesion PMID: 11906941
    5. Because fertilin beta is absent from calmegin-deficient mice, the role of fertilin beta in sperm-EPM interaction needs to be reevaluated. PMID: 12376108
    6. ADAM1a/ADAM2 Fertilin complex has roles in expression of ADAM3 on the cell surface of mouse sperm PMID: 15194697
    7. ADAM2 is involved in protein trafficking during sperm development PMID: 16014818
    8. These results suggest that mouse ADAM1b/ADAM2 fertilin may play a crucial role not in the sperm/egg fusion but in the appearance of these two ADAMs on the sperm surface. PMID: 16407235
    9. Results suggest that association with ADAM2 is a key element for stability of ADAM3 in epididymal sperm, and the presence of the ADAM2-ADAM3 complex in sperm also suggests a potential role of ADAM2 with ADAM3 in sperm binding to the egg zona pellucida. PMID: 17439939
    10. ADAM2 contributes to migration from the subventricular zone along the rostral migratory stream, possibly through cell-cell interactions that mediate the rapid migration of the neuroblasts to their endpoint. PMID: 18380661

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  • 亚细胞定位：
    Membrane; Single-pass type I membrane protein.
  • 组织特异性：
    Expressed specifically in testis.
  • 数据库链接：

    KEGG: mmu:11495

    STRING: 10090.ENSMUSP00000022618

    UniGene: Mm.422850