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  4. Recombinant Mouse Dihydropyrimidinase-related protein 2 (Dpysl2)

Recombinant Mouse Dihydropyrimidinase-related protein 2 (Dpysl2)

  • 中文名称：
    小鼠Dpysl2重组蛋白
  • 货号：
    CSB-YP007170MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Dpysl2重组蛋白
  • 货号：
    CSB-EP007170MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Dpysl2重组蛋白
  • 货号：
    CSB-EP007170MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Dpysl2重组蛋白
  • 货号：
    CSB-BP007170MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Dpysl2重组蛋白
  • 货号：
    CSB-MP007170MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Dpysl2
  • Uniprot No.：
  • 别名：
    Dpysl2; Crmp2; Ulip2Dihydropyrimidinase-related protein 2; DRP-2; Unc-33-like phosphoprotein 2; ULIP-2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-572
  • 氨基酸序列
    MSYQGKKNIP RITSDRLLIK GGKIVNDDQS FYADIYMEDG LIKQIGENLI VPGGVKTIEA HSRMVIPGGI DVHTRFQMPD QGMTSADDFF QGTKAALAGG TTMIIDHVVP EPGTSLLAAF DQWREWADSK SCCDYSLHVD ITEWHKGIQE EMEALVKDHG VNSFLVYMAF KDRFQLTDSQ IYEVLSVIRD IGAIAQVHAE NGDIIAEEQQ RILDLGITGP EGHVLSRPEE VEAEAVNRSI TIANQTNCPL YVTKVMSKSA AEVIAQARKK GTVVYGEPIT ASLGTDGSHY WSKNWAKAAA FVTSPPLSPD PTTPDFLNSL LSCGDLQVTG SAHCTFNTAQ KAVGKDNFTL IPEGTNGTEE RMSVIWDKAV VTGKMDENQF VAVTSTNAAK VFNLYPRKGR ISVGSDADLV IWDPDSVKTI SAKTHNSALE YNIFEGMECR GSPLVVISQG KIVLEDGTLH VTEGSGRYIP RKPFPDFVYK RIKARSRLAE LRGVPRGLYD GPVCEVSVTP KTVTPASSAK TSPAKQQAPP VRNLHQSGFS LSGAQIDDNI PRRTTQRIVA PPGGRANITS LG
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis.
  • 基因功能参考文献：
    1. postulate that this state forces CRMP2 toward a monomer, exposing the SUMO site and consequently, resulting in constitutive regulation of NaV1.7. PMID: 28277940
    2. These results revealed that bilateral ligation of the internal carotid artery causes retinal ischemia in mice. Moreover, CRMP2 might play a pivotal role during the ischemic injury in the retina and inhibit the cleavage of CRMP2 can ameliorate the IH injury. PMID: 28524835
    3. The findings reveal a critical role for CRMP2 in neuronal plasticity, neural function and behavioral modulation in mice. PMID: 27249678
    4. Results suggested that crmp2 is a target of miR-181c and that the abnormally low expression of miR-181c in the hippocampus of SAMP8 mice could lead to an increase of the crmp2 protein level in Alzheimer's disease mice, which might potentially play a role in the pathogenesis of Alzheimer's disease PMID: 27423553
    5. These results suggest a correlation between CRMP2 phosphorylation and AD pathophysiology, and indicate the effectiveness of pioglitazone treatment at the pre-Abeta accumulation stage in AD model mice. PMID: 27059136
    6. study implies that dysregulation of CRMP2 may be involved in pathophysiology of neuropsychiatric disorders PMID: 27582038
    7. We propose that CRMP2 could contribute to long-lasting synaptic plasticity. PMID: 26250894
    8. This study shows that in young adult mice, motor and sensory functions lost by SCI can be recovered with a single genetic mutation to inhibit CRMP2 phosphorylation PMID: 26795088
    9. Study showed that axon degeneration is an early and dominant feature in dopaminergic neurons treated with 1-methyl-4-phenylpyridiniumion (MPP+), and that the Akt/GSK-3beta/CRMP-2 pathway is involved in axon degeneration induced by MPP+ PMID: 25150591
    10. Clear differences in CRMP2 protein abundance and degradation product/short isoform were observed between ischemic core and penumbra and also compared to the contralateral healthy tissues after PACAP38 or saline treatment. PMID: 25257527
    11. Glycogen synthase kinase 3beta has a role in microtubule remodeling in compensatory glomerular adaptation to podocyte depletion through Tau and CRMP2 PMID: 25468908
    12. Levels of total GSK3 were decreased in the Huntington disease-affected frontal cortex and this correlated with decreased phosphorylated CRMP2. PMID: 24634145
    13. Long-term vitamin E-deficiency led to significantly increased expression of the phosphorylated form of collapsin response mediator protein (CRMP)-2 compared to short-term deficiency. PMID: 24568262
    14. Noncanonical kainate receptor signaling influences neuronal development by modulating CRMP2 activity. PMID: 24227739
    15. a novel regulatory mechanism that utilizes CRMP2 SUMOylation to choreograph NaV1.7 trafficking. PMID: 23836888
    16. A novel glycogen synthase kinasealpha/beta CRMP-2 pathway is identified that connects neuronal activity to dendritic growth. PMID: 23470087
    17. CRMP2 phosphorylation is critical for proper bifurcation of apical dendrite of CA1 pyramidal neurons PMID: 22826151
    18. Two novel matrix metallopeptidase 9 targets were identified: synaptic cell adhesion molecule-2 and collapsin response mediator protein-2 PMID: 22694054
    19. This study demonistrated that phosphorylation of CRMP-2 may be downstream of NgR1 activation and play a role in axonal degeneration in experimental autoimmune encephalomyelitis and multiple sclerosis. PMID: 22544872
    20. The E3 ligase (ZNRF1)-AKT-glycogen synthase kinase-3beta (GSK3B)-CRMP2 pathway plays an important role in controlling Wallerian degeneration. PMID: 22057101
    21. Activation of CRMP-2 is increased in the hippocampus of transgenic mice at 12 weeks of age when compared with wild-type littermate mice. PMID: 20682295
    22. The phosphorylation of CRMP2 protein, a GSK-3beta substrate that plays a crucial role in Semaphorin3a-mediated axonal guidance. PMID: 16230462
    23. Rho kinase phosphorylates CRMP-2, and inactivates the ability of CRMP-2 to promote microtubule assembly and Numb-mediated endocytosis, during growth cone collapse PMID: 16260611
    24. We show that Crmp-2 undergoes dynamic phosphorylation changes in response to contact inhibition-induced quiescence and that hyperphosphorylation of Crmp-2 occurs in a tumor. PMID: 16414354
    25. High CRMP2 expression in peripheral T lymphocytes is associated with recruitment to the brain during virus-induced neuroinflammation. PMID: 18006081
    26. association of neurofibromin and CRMP-2 is essential for neuronal cell differentiation PMID: 18218617
    27. Hypoxia-ischemia (HI)induces dephosphorylation of CRMPs (CRMP1, 2, and 5) in neonatal brain. Hypophosphorylated CRMPs might be implicated in the pathogenesis of HI-related neurological disorders. PMID: 18471005
    28. We concluded that alterations in neurite maturation resulting from a loss of CLN6-CRMP-2 interaction may contribute to neuronal dysfunction and pathology in vLINCL. PMID: 19235893

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  • 亚细胞定位：
    Cytoplasm, cytosol. Cytoplasm, cytoskeleton. Membrane.
  • 蛋白家族：
    Metallo-dependent hydrolases superfamily, Hydantoinase/dihydropyrimidinase family
  • 数据库链接：

    KEGG: mmu:12934

    STRING: 10090.ENSMUSP00000022629

    UniGene: Mm.352648