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  4. Recombinant Mouse Differentially expressed in FDCP 6 (Def6)

Recombinant Mouse Differentially expressed in FDCP 6 (Def6)

  • 中文名称：
    Recombinant Mouse Differentially expressed in FDCP 6(Def6),Yeast
  • 货号：
    CSB-YP804907MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Differentially expressed in FDCP 6(Def6),Yeast
  • 货号：
    CSB-EP804907MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Differentially expressed in FDCP 6(Def6),Yeast
  • 货号：
    CSB-EP804907MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Differentially expressed in FDCP 6(Def6),Yeast
  • 货号：
    CSB-BP804907MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Differentially expressed in FDCP 6(Def6),Yeast
  • 货号：
    CSB-MP804907MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Def6
  • Uniprot No.：
  • 别名：
    Def6; Ibp; SlatDifferentially expressed in FDCP 6; DEF-6; IRF4-binding protein; SWAP-70-like adapter of T-cells
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-630
  • 氨基酸序列
    MALRKELLKS IWYAFTALDV EKSGKVSKSQ LKVLSHNLYT VLNIPHDPVA LEEHFRDDDD GPVSSQGYMP YLNKYILDKV EEGAFVKEHF DELCWTLTAK KNYRADGIGS SPLSNQDAFR LWCLFNFLSE DKYPLIMVPD EVEYLLKKLL GSLSLEMGLG ELEELLAQDA QSAQTAVGLS VWQFLELFNS GRCLRGVGRD SLSMAIQEVY QELIQDVLKQ GYLWKRGHLR RNWAERWFQL QPSSLCYFGS EECKEKRGTI PLDAHCCVEV LPDREGKRCM FCVKTASRTY EMSASDTRQR QEWTAAIQTA IRLQAEGKTS LHKDLKQKRR EQREQRERRR AAKEEELLRL QQLQEEKERK LQELELLQEA QRQAERLLQE EEERRRSQHK ELQQALEGQL REAEQARASM QAEMELKKEE AARQRQRIAE LEEMQERLQE ALQLEVKARR DEEAVRLAQT RLLEEEEEKL KQLMHLKEEQ ERYIERAQQE KQELQQEMAL QSRSLQHAQQ QLEEVRQNRQ RADEDVEAAQ RKLRQASTNV KHWNVQMNRL MHPIEPGDKR PTTSSSFTGF QPPPLARRDS SLKRLTRWGS QGNRTLSVNS SEQKSLNGGD ETPILALASQ EEKLDPAPGN
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which plays a role in the activation of Rho GTPases RAC1, RhoA and CDC42. Can regulate cell morphology in cooperation with activated RAC1. Plays a role in Th2 (T helper cells) development and/or activation, perhaps by interfering with ZAP70 signaling. Required for optimal T-cell effector function, lymphocyte homeostasis and the prevention of systemic autoimmunity.
  • 基因功能参考文献：
    1. this study identifies Def6 as a novel inhibitor of osteoclastogenesis in physiological and inflammatory conditions PMID: 28314855
    2. These findings ascribe a new function to SLAT, and identify Rap1 as a target of SLAT function in TCR-mediated inside-out signaling. PMID: 26483383
    3. SLAT is an IP3R1-interacting protein required for T cell activation. PMID: 25270259
    4. PKClambda/iota was identified as an important factor for actin cytoskeletal regulation in podocytes and Def-6 as a specific downstream target of PKClambda/iota that regulates the activity of small GTPases and subsequently the actin cytoskeleton of podocytes. PMID: 24096077
    5. SLAT-mediated nuclear factor of activated T-cell (NFAT)1 activation is required for efficient expansion of CD8+ T cells during the primary response but is not necessary for cytotoxic T lymphocyte (CTL) differentiation. PMID: 23197258
    6. SLAT/Def6 plays a major role in the T cell-mediated autoimmune processes that bring about the inflammatory eye disease, experimental autoimmune uveitis. PMID: 22815639
    7. plays a role in Th2 development and/or activation, perhaps by interfering with ZAP-70 signaling PMID: 12648457
    8. tyrosine-phosphorylation-mediated relocalization of SLAT to the site of antigen recognition is required for SLAT to exert its pivotal role in NFAT-dependent CD4(+) T cell differentiation. PMID: 18976935
    9. IRF-4-binding protein sequestered IRF-4 and prevented it from targeting the transcriptional regulatory regions of the genes that encode IL-17 and IL-21. PMID: 19062315
    10. IBP/Def6 as a novel component of the TLR4-induced signaling cascade that controls the production of proinflammatory cytokines PMID: 19074553
    11. SLAT acts as a gatekeeper for the amount of Rac recruited to the phagosomes formed by Fcgamma receptor engagement and thus is able to regulate F-actin re-organization and consequently phagocytosis. PMID: 19251698
    12. our study establishes T cell-expressed SLAT/Def6 as a pivotal positive regulator of Th17 inflammatory responses and, thus, essential in controlling autoimmune and inflammatory diseases. PMID: 19915062
    13. def6 was first identified in a retroviral gene-trap screen PMID: 10460589

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  • 相关疾病：
    Defects in Def6 results in spontaneous development of a lupus-like syndrome in aging female mice. It is characterized by the accumulation of effector/memory T-cells and IgG B-cells, profound hypergammaglobulinemia, autoantibody production, and glomerulonephritis.
  • 亚细胞定位：
    Cytoplasm. Cell membrane. Nucleus. Cytoplasm, cytoskeleton. Cytoplasm, perinuclear region. Cell projection, filopodium.
  • 组织特异性：
    Thymus.
  • 数据库链接：

    KEGG: mmu:23853

    STRING: 10090.ENSMUSP00000002327

    UniGene: Mm.204731