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  4. Recombinant Mouse Delta (24)-sterol reductase (Dhcr24), partial

Recombinant Mouse Delta (24)-sterol reductase (Dhcr24), partial

  • 中文名称：
    小鼠Dhcr24重组蛋白
  • 货号：
    CSB-YP844991MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    小鼠Dhcr24重组蛋白
  • 货号：
    CSB-EP844991MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    小鼠Dhcr24重组蛋白
  • 货号：
    CSB-EP844991MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    小鼠Dhcr24重组蛋白
  • 货号：
    CSB-BP844991MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    小鼠Dhcr24重组蛋白
  • 货号：
    CSB-MP844991MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Dhcr24
  • Uniprot No.：
  • 别名：
    Dhcr24; Kiaa0018; Delta(24)-sterol reductase; EC 1.3.1.72; 24-dehydrocholesterol reductase; 3-beta-hydroxysterol Delta-24-reductase
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. In addition to its cholesterol-synthesizing activity, can protect cells from oxidative stress by reducing caspase 3 activity during apoptosis induced by oxidative stress. Also protects against amyloid-beta peptide-induced apoptosis.
  • 基因功能参考文献：
    1. When DHCR24 is genetically deleted there is a decreased association of EAAT2 with lipid rafts after ischemia. PMID: 26628388
    2. Data (including data from transgenic mice) suggest that expression of Dhcr24 is down-regulated in brain tissues of mice exhibiting symptoms modeling advanced Huntington's disease. PMID: 24916565
    3. RE1-silencing transcription factor acts because it is bound in close proximity to SREBP, thus amplifying its ability to upregulate 24-dehydrocholesterol reductase PMID: 24861183
    4. concluded that TH up-regulates Seladin-1 gene expression at the transcriptional level and LXR-alpha maintains the gene expression PMID: 23359226
    5. This is the first demonstration that DHCR24 plays an important role in long bone growth by protecting chondrocytes from reactive oxygen species. PMID: 21845517
    6. Seladin-1 is shown to be an LPS-responsive gene that negatively regulates the TNF- alpha production and bone resorption in response to LPS. PMID: 20406300
    7. Seladin-1-dependent cholesterol synthesis is involved in lowering Abeta levels. PMID: 16407971
    8. cellular cholesterol biosynthesis is critical for the activation and maintenance of the Akt-Bad cell survival cascade in response to growth factors such as insulin. PMID: 16513830
    9. Cholesterol homeostasis in Dhcr24 knockout mice is characterized by strong activation of liver X receptor-targeted genes and by mechanisms compensating for cholesterol depletion. PMID: 17761942
    10. ablation of DHCR24/seladin-1 prevented apoptosis of primary neurons in a p53-dependent manner PMID: 17984220
    11. DHCR24 plays important roles for normal development of epidermis and hair follicle even in postnatal life. PMID: 19542918

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  • 亚细胞定位：
    Endoplasmic reticulum membrane; Single-pass membrane protein. Golgi apparatus membrane; Single-pass membrane protein.
  • 蛋白家族：
    FAD-binding oxidoreductase/transferase type 4 family
  • 数据库链接：

    KEGG: mmu:74754

    STRING: 10090.ENSMUSP00000038063

    UniGene: Mm.133370