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  4. Recombinant Mouse Cytochrome P450 2C29 (Cyp2c29)

Recombinant Mouse Cytochrome P450 2C29 (Cyp2c29)

  • 货号：
    CSB-YP714494MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP714494MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP714494MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP714494MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP714494MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
    Cyp2c29
  • Uniprot No.：
  • 别名：
    Cyp2c29Cytochrome P450 2C29; EC 1.14.14.1; Aldehyde oxygenase; CYPIIC29; Cytochrome P-450 MUT-2
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-490
  • 氨基酸序列
    MDLVVFLALT LSCLILLSLW RQSSGRGKLP PGPTPLPIIG NFLQIDVKNI SQSFTNFSKA YGPVFTLYLG SKPTVILHGY EAVKEALIDR GEEFAGRGSF PMAEKIIKGF GVVFSNGNRW KEMRRFTLMT LRNLGMGKRN IEDRVQEEAQ CLVEELRKTK GSPCDPTFIL SCAPCNVICS IIFQNRFDYK DKEFLILMDK INENVKILSS PWLQVCNSFP SLIDYCPGSH HKIVKNFNYL KSYLLEKIKE HKESLDVTNP RDFIDYYLIK QKQVNHIEQS EFSLENLAST INDLFGAGTE TTSTTLRYAL LLLLKYPDVT AKVQEEIDRV VGRHRSPCMQ DRSHMPYTDA MIHEVQRFID LLPTSLPHAV TCDIKFRKYL IPKGTTVITS LSSVLHDSKE FPNPEMFDPG HFLNGNGNFK KSDYFMPFST GKRICAGEGL ARMELFLILT TILQNFKLKS LVHPKEIDIT PVMNGFASLP PPYQLCFIPL
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    A cytochrome P450 monooxygenase that selectively catalyzes the epoxidation of 14,15 double bond of (5Z,8Z,11Z,14Z)-eicosatetraenoic acid (arachidonate) forming 14,15-epoxyeicosatrienoic acid (14,15-EET) regioisomer. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH--hemoprotein reductase).
  • 基因功能参考文献：
    1. Gene-targeted knockdown of CYP2C55, the homologous gene of CYP2C9, demonstrated viability rescue to light-induced cell death, whereas stable expression of functional CYP2C9-GFP fusion protein further exacerbated light-induced cell death. PMID: 24519941
    2. CYP2C29 synthesizes EETs to mediate SSID, and simultaneously releases superoxide and sequential H(2)O(2), which in turn impair SSID. PMID: 22708815
    3. Midlozam metabolism in Cyp3a knockout mice can be attributed to up-regulated Cyp2c enzymes. PMID: 18156313
    4. Report role of CYP2c29/CYP4a in A2A AR-mediated relaxation using A2A AR-null and wild-type mice. PMID: 18805895
  • 亚细胞定位：
    Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
  • 蛋白家族：
    Cytochrome P450 family
  • 组织特异性：
    Expressed in liver as well as in extrahepatic tissues including brain, kidney, lung, heart, and intestine.
  • 数据库链接：

    KEGG: mmu:13095

    STRING: 10090.ENSMUSP00000003137

    UniGene: Mm.20764