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  4. Recombinant Mouse Cyclin-dependent kinase 4 inhibitor D (Cdkn2d)

Recombinant Mouse Cyclin-dependent kinase 4 inhibitor D (Cdkn2d)

  • 货号：
    CSB-YP730656MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP730656MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP730656MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP730656MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP730656MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Cdkn2d; Cyclin-dependent kinase 4 inhibitor D; p19-INK4d
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-166
  • 氨基酸序列
    MLLEEVCVGD RLSGAAARGD VQEVRRLLHR ELVHPDALNR FGKTALQVMM FGSPAVALEL LKQGASPNVQ DASGTSPVHD AARTGFLDTL KVLVEHGADV NALDSTGSLP IHLAIREGHS SVVSFLAPES DLHHRDASGL TPLELARQRG AQNLMDILQG HMMIPM
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Interacts strongly with CDK4 and CDK6 and inhibits them.
  • 基因功能参考文献：
    1. Rescue from early-onset hearing loss in a mouse model lacking the cyclin-dependent kinase inhibitor p19Ink4d. PMID: 26962681
    2. p19 INK4d controls hematopoietic stem cells in a cell-autonomous manner during genotoxic stress and through the microenvironment during aging PMID: 25458892
    3. Deletion of p19(Ink4d) (p19), a cyclin-dependent kinase CDK inhibitor gene, in mice results in spontaneous development of tumors in multiple organs and tissues. PMID: 24687853
    4. We propose that p19INK4d participates in the cellular mechanisms that trigger senescence by contributing to chromatin compaction PMID: 24667034
    5. an asymmetrical distribution pattern for Cdkn2d transcripts in 2-cell embryos. PMID: 22071115
    6. Ectopic expression of RUVBL2 decreases the levels of ARF, whereas knockdown of RUVBL2 results in a marked increase in ARF levels. In addition, RUVBL2 down-regulates the levels of p53 in an ARF-dependent manner. PMID: 22285491
    7. A significant proportion of immortalised cell cultures apparently had neither a p53 mutation nor loss of p19/ARF. PMID: 20378935
    8. Deletion of Ink4d alone is sufficient to disrupt the maintenance of the post-mitotic state of sensory hair cells in post-natal mice. In Ink4d-/- animals, hair cells re-enter the cell cycle and undergo apoptosis, resulting in progressive hearing loss. PMID: 12717441
    9. Cranial neural crest-derived mesenchymal proliferation is regulated by Msx1-mediated p19(INK4d) expression during odontogenesis. PMID: 12941628
    10. These studies indicate that a reduction in Ink4 family function by the loss of p19(Ink4d) is sufficient to induce mild reproductive defects in male mice with a mixed genetic background, but not in the C57BL/6 genetic background. PMID: 17393423
    11. p19(INK4D) knockdown led to a moderate increase (31.7% +/- 5%) in the mean ploidy of megakaryocytes suggesting a role of p19(INK4D) in the endomitotic arrest. PMID: 18276842

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  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    CDKN2 cyclin-dependent kinase inhibitor family
  • 数据库链接：

    KEGG: mmu:12581

    STRING: 10090.ENSMUSP00000083561

    UniGene: Mm.29020