Your Good Partner in Biology Research

  1. 首页
  2. 蛋白
  3. 重组蛋白
  4. Recombinant Mouse Cyclin-dependent kinase 4 inhibitor C (Cdkn2c)

Recombinant Mouse Cyclin-dependent kinase 4 inhibitor C (Cdkn2c)

  • 货号：
    CSB-YP720172MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP720172MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP720172MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP720172MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP720172MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Cdkn2cCyclin-dependent kinase 4 inhibitor C; Cyclin-dependent kinase 6 inhibitor; p18-INK4c; p18-INK6
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    full length protein
  • 表达区域：
    1-168
  • 氨基酸序列
    MAEPWGNELA SAAARGDLEQ LTSLLQNNVN VNAQNGFGRT ALQVMKLGNP EIARRLLLRG ANPNLKDGTG FAVIHDAARA GFLDTVQALL EFQADVNIED NEGNLPLHLA AKEGHLPVVE FLMKHTACNV GHRNHKGDTA FDLARFYGRN EVISLMEANG VGGATSLQ
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Interacts strongly with CDK6, weakly with CDK4. Inhibits cell growth and proliferation with a correlated dependence on endogenous retinoblastoma protein RB.
  • 基因功能参考文献：
    1. Gata3 deficiency promotes B cell differentiation and proliferation, and cooperates with p18 loss to induce B cell lymphomas PMID: 27588406
    2. Host Tumor Suppressor p18(INK4c) Functions as a Potent Cell-Intrinsic Inhibitor of Murine Gammaherpesvirus 68 Reactivation and Pathogenesis. PMID: 29298882
    3. CD4+ T cells from mice genetically deficient for p18ink4c divide more rapidly than wild-type cells in response to antigenic, costimulatory and growth factor signals. PMID: 24614758
    4. p18 represents a potent and specific target for enhancing the self-renewal property of HSC, as demonstrated the effect of inhibitors PMID: 25692908
    5. p18 may play protective roles and may be associated with or partially account for the cytoprotective effects of HO-1 in cisplatin-induced acute kidney injury. PMID: 24993528
    6. Gata3/Ruvbl2 complex regulates T helper 2 cell proliferation via repression of Cdkn2c expression. PMID: 24167278
    7. deletion of P18 results in a deacreased proliferation of hematopoietic progenitor cells (HPCs) suggesting a positive role for P18 on HPCs in vivo PMID: 21936707
    8. A p18 -74 C/T mutation is the leading causal variant for the cell expansion that characterizes NZB and NZM2410 lupus-prone mouse strains. PMID: 22504641
    9. Cdkn2c plays a critical role in B1a cell self-renewal and its impaired expression leads to an accumulation of these cells with high autoreactive potential. PMID: 21543644
    10. define the first physiologic function for Noxa and suggest that by repressing Noxa, induction of G arrest by p18INK4c bypasses a homeostatic cell-cycle checkpoint in intermediate plasma cells (iPCs) for PC differentiation PMID: 21163929
    11. CDK inhibitor p18(INK4c) is required for the generation of functional plasma cells PMID: 12196289
    12. Here we show that treatment of p18 null and heterozygous mice with a chemical carcinogen resulted in tumor development at an accelerated rate.Hence, p18 is a haploinsufficient tumor suppressor in mice. PMID: 12556487
    13. p18 is involved in cell cycle progression after partial hepatectomy. PMID: 12668976
    14. Ink4 proteins might function in governing neuronal cell cycle exit as well as in a non-cell-autonomous manner in controlling the production of diffusible mitogens and chemokines that influence postnatal development of the cerebellar EGL. PMID: 14500377
    15. p19(INK4d) in addition to p21(WAF1/Cip1) is an important molecular target of HDAC inhibitors inducing growth arrest PMID: 15107822
    16. Results show that deletion of p18(INK4C) results in strikingly improved long-term engraftment, largely by increasing self-renewing divisions of the primitive cells in murine transplant models. PMID: 15122268
    17. p18(Ink4c) is functionally dependent on CDK4 PMID: 15254233
    18. Antagonistic cell-cycle regulation by tumor necrosis factor (ligand) superfamily, member 13b and p18(INK4c) is functionally linked to apoptotic control PMID: 15591344
    19. Coinactivation of Ink4c and p53 provides cultured cerebellar granule neuronal precursor cells with an additive proliferative advantage and induces medulloblastoma with low penetrance but with greatly increased incidence following postnatal irradiation. PMID: 16260494
    20. p18Ink4c and Pten cooperate in tumor suppression by constraining a positive regulatory loop between cell growth and cell cycle control pathways. PMID: 16738322
    21. Results describe the expression of p18(Ink4c) and p19(Ink4d) in spermatogenic and supporting cells in the testis and in pituitary gonadotropes. PMID: 17342741
    22. Data suggest that EKLF is a direct regulator of p18(INK4c) gene expression, and much of EKLF's role in driving erythroid cell differentiation may occur via p18(INK4c). PMID: 17442339
    23. oncogenic RET and loss of p18 cooperate in the multistep tumorigenesis of medullary thyroid carcinoma PMID: 18316595
    24. Studies identify p18(INK4c) as a glioblastoma multiforme tumor suppressor gene, revealing an additional mechanism leading to aberrant activation of cyclin/cdk complexes in this terrible malignancy. PMID: 18381405
    25. p18Ink4c and p19Ink4d protein levels are not only differentially regulated by the ubiquitin-proteasome pathway, but are subject to completely opposite modes of regulation when associated with their target Cdks. PMID: 19029828
    26. Cdk4 inhibitor p18(Ink4c) is a tumor suppressor in cyclin D1-driven PNET. PMID: 19147556
    27. p18(INK4C) is a downstream target of GATA3, constrains luminal progenitor cell expansion, and suppresses luminal tumorigenesis in the mammary gland PMID: 19411068

    显示更多

    收起更多

  • 蛋白家族：
    CDKN2 cyclin-dependent kinase inhibitor family
  • 数据库链接：

    KEGG: mmu:12580

    STRING: 10090.ENSMUSP00000070313

    UniGene: Mm.1912