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  4. Recombinant Mouse Cyclin-A2 (Ccna2)

Recombinant Mouse Cyclin-A2 (Ccna2)

  • 货号：
    CSB-YP004805MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP004805MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP004805MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP004805MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP004805MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Ccna2; Ccna; Cyca; Cyca2; Cyclin-A2; Cyclin-A
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full length protein
  • 表达区域：
    1-422
  • 氨基酸序列
    MPGTSRHSGR DAGSALLSLH QEDQENVNPE KLAPAQQPRA QAVLKAGNVR GPAPQQKLKT RRVAPLKDLP INDEHVTAGP SWKAVSKQPA FTIHVDEAEE TQKRPAELKE TECEDALAFN AAVSLPGARK PLTPLDYPMD GSFESPHAMD MSIVLEDKPV NVNEVPDYQE DIHTYLREME VKCKPKVGYM KRQPDITNSM RAILVDWLVE VGEEYKLQNE TLHLAVNYID RFLSSMSVLR GKLQLVGTAA MLLASKFEEI YPPEVAEFVY ITDDTYSKKQ VLRMEHLVLK VLAFDLAAPT VNQFLTQYFL HLQPANCKVE SLAMFLGELS LIDADPYLKY LPSLIAGAAF HLALYTVTGQ SWPESLAQQT GYTLESLKPC LVDLHQTYLK APQHAQQSIR EKYKHSKYHS VSLLNPPETL SV
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Cyclin which controls both the G1/S and the G2/M transition phases of the cell cycle. Functions through the formation of specific serine/threonine kinase holoenzyme complexes with the cyclin-dependent protein kinases CDK1 and CDK2. The cyclin subunit confers the substrate specificity of these complexes and differentially interacts with and activates CDK1 and CDK2 throughout the cell cycle.
  • 基因功能参考文献：
    1. We demonstrate that CCNA2-null progenitors suffer abnormal DNA repair, and implicate Cyclin A2 in double-strand break repair. Cyclin A2's DNA repair functions are conserved among cell lines, neural progenitors, and hippocampal neurons. We further demonstrate that neuronal CCNA2 ablation results in learning and memory deficits in aged mice. PMID: 27425845
    2. cyclin A2 mediates the fidelity ofmeiosis II by maintaining microtubule dynamics during the rapid formation of the meiosis II spindle. PMID: 28819014
    3. These data unveils the critical functions of cyclin A2 in regulating mammalian erythropoiesis. PMID: 27657745
    4. Meioc-deficient spermatocytes that have initiated synapsis mis-express CYCLIN A2, which is normally expressed in mitotic spermatogonia, suggesting a failure to properly transition to a meiotic cell cycle program. PMID: 28380054
    5. inhibition of PDK4 activity in Hepatocellular carcinoma cells increased cyclin E1, cyclin A2, and E2F1 proteins. PMID: 28003426
    6. cyclin A2 controlled Mre11 abundance through a C-terminal RNA binding domain that selectively and directly binds Mre11 transcripts to mediate polysome loading and translation. PMID: 27708105
    7. hese data suggest that mmu-miR-125b decreases NO production in activated macrophages at least partially by suppressing eEF2K and CCNA2 expression. PMID: 27020049
    8. Ccn2 is a regulator of the transition through cytokinesis during terminal erythropoiesis. PMID: 25615569
    9. Loss of CCNA2 decreases cell proliferation and induces cerebellar cortical dyslamination. PMID: 25668568
    10. Data indicate that cyclin A2-depleted epithelial cells adopt a fibroblastic morphology and undergo epithelial to mesenchymal transition (EMT). PMID: 24879294
    11. The activity of PCTK3 is increased via interaction with cyclin A2 and phosphorylation by PKA. PMID: 24831015
    12. AMPKalpha1 controlled cyclin A2 transcription mainly through the ATF/CREB element PMID: 24012615
    13. Loss of Cdk2 and cyclin A2 impairs cell proliferation and tumorigenesis. PMID: 24802190
    14. Conditional knockout of cyclin A2 or the SHH proliferative target Nmyc in CGNP also resulted in PC neuron dyslamination PMID: 24184637
    15. decreased miR-124 expression could increase CCNA2 in cell and animal model of HD and is involved in deregulation of cell cycle in STHdh(Q111)/Hdh(Q111) cells PMID: 23796713
    16. The requirement of cyclin A2 for entry into meiosis I and for sister chromatid segregation in meiosis II in mouse oocytes. PMID: 23122964
    17. Cyclin A expression confirmed a prolifer-ative response in cirrhotic livers in response to mitogens. PMID: 22243368
    18. Study suggested that OGP may increase the bone formation in OPG-deficient mice by stimulating MSC proliferation rather than differentiation, and probably by triggering CDK2/cyclin A pathway. PMID: 20926513
    19. CCN1 is a novel, endogenous "parent compound" for chemotaxis modulation. PMID: 21135363
    20. transcription of the gene for cyclin-A2 appears to be a direct target of JDP2 in the suppression of cell proliferation PMID: 20802531
    21. cyclin A may induce S phase arrest associated with apoptosis in 3-methylcholanthrene-induced fibrosarcomas. PMID: 18621517
    22. cyclin A expression is inhibited by bicalutamide both in androgen-dependent and -independent cell lines PMID: 20126974
    23. CCN1 is a novel component of the extracellular matrix that activates proinflammatory genes in macrophages, implicating its role in regulating macrophage function during inflammation. PMID: 20164416
    24. Data show that the presence of the truncated form of cyclin A2 in differentiating embryonic stem cells is not a function of cell density but is correlated with differentiation. PMID: 12646244
    25. cyclin A levels are regulated by c-Fos in osteoblast growth control PMID: 14699150
    26. critical role in mediating cardiomyocyte mitosis, a role that may significantly impact upon clinical treatment of damaged myocardium. PMID: 15159393
    27. expression pattern during the first three cell cycles of mouse embryo development PMID: 15214576
    28. B-Myb represses SMC elastin gene expression and cyclin A plays a role in the developmental regulation of elastin gene expression in the aorta PMID: 15615710
    29. recruitment of maternal cyclin A2 mRNA following egg activation is linked to embryonic gene activation PMID: 16137671
    30. Expression of cyclin A2 augments endogenous regenerative mechanisms via induction of enhanced cell proliferative capacity. Ability of cultured transgenic cardiomyocytes to undergo cytokinesis provides support for the regenerative capacity of cyclin A2. PMID: 17495221
    31. Results indicate that the NFAT1 transcription factor represses cyclin A2 expression in lymphocytes, and may act as a silencer of gene transcription during the cell cycle. PMID: 17637565
    32. PtdIns(4,5)P2 down-regulation caused a delay in phorbol ester-induced S phase entry and that this was at least in part channeled through cyclin A2 at the transcriptional level. PMID: 18077453
    33. REVIEW.Some cyclins exhibit unique patterns of expression in germ cells that suggest possible concomitant distinct functions; embryonic lethality has obviated understanding of the germline functions of cyclin A2 and cyclin B1 PMID: 19001847
    34. cyclin A2-Cdk1 is a key regulator of S-phase programs PMID: 19221029
    35. Results identify the phosphorylated residues in mouse Cyclin-A2 and CDK2 recombinant proteins, after individual expression and after formation of the heterodimer complex. PMID: 19233286
    36. MLL5 plays an integral role in novel chromatin regulatory mechanisms that suppress inappropriate expression of S-phase-promoting genes and maintain expression of determination genes in quiescent cells. PMID: 19264965
    37. Study found that acute ablation of cyclin A in fibroblasts did not affect cell proliferation, in contrast, cyclin A function was essential for cell-cycle progression of hematopoietic and embryonic stem cells. PMID: 19592082

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  • 亚细胞定位：
    Nucleus. Cytoplasm.
  • 蛋白家族：
    Cyclin family, Cyclin AB subfamily
  • 组织特异性：
    Ubiquitous. In the testis, expressed in germ cells and in the ovary, in both germline and somatic cells.
  • 数据库链接：

    KEGG: mmu:12428

    STRING: 10090.ENSMUSP00000029270

    UniGene: Mm.4189