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  4. Recombinant Mouse Cyclic AMP-responsive element-binding protein 3-like protein 3 (Creb3l3), partial

Recombinant Mouse Cyclic AMP-responsive element-binding protein 3-like protein 3 (Creb3l3), partial

  • 中文名称：
    Recombinant Mouse Cyclic AMP-responsive element-binding protein 3-like protein 3(Creb3l3),partial,Yeast
  • 货号：
    CSB-YP821011MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 中文名称：
    Recombinant Mouse Cyclic AMP-responsive element-binding protein 3-like protein 3(Creb3l3),partial,Yeast
  • 货号：
    CSB-EP821011MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 中文名称：
    Recombinant Mouse Cyclic AMP-responsive element-binding protein 3-like protein 3(Creb3l3),partial,Yeast
  • 货号：
    CSB-EP821011MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名称：
    Recombinant Mouse Cyclic AMP-responsive element-binding protein 3-like protein 3(Creb3l3),partial,Yeast
  • 货号：
    CSB-BP821011MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 中文名称：
    Recombinant Mouse Cyclic AMP-responsive element-binding protein 3-like protein 3(Creb3l3),partial,Yeast
  • 货号：
    CSB-MP821011MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    Creb3l3; CrebhCyclic AMP-responsive element-binding protein 3-like protein 3; cAMP-responsive element-binding protein 3-like protein 3; Transcription factor CREB-H) [Cleaved into: Processed cyclic AMP-responsive element-binding protein 3-like protein 3]
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Partial
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Transcription factor that may act during endoplasmic reticulum (ER) stress by activating unfolded protein response target genes. Activated in response to cAMP stimulation. Binds to the cAMP response element (CRE). Activates transcription through box-B element. Activates transcription through CRE. May function synergistically with ATF6. In acute inflammatory response, may activate expression of acute phase response (APR) genes. May be involved in growth suppression. Regulates FGF21 transcription.
  • 基因功能参考文献：
    1. CREB3L3 plays a crucial role in hepatic adaptation to energy starvation via two pathways: direct related gene regulation and an auto-loop activation of PPAR alpha. PMID: 27982131
    2. These results uncover a negative feedback loop in which CREBH regulates nonesterified fatty acid flux from adipose tissue to the liver via FGF21. PMID: 27301791
    3. CREBH mediates inflammatory signaling to VLDL overproduction in metabolic stress. Activation of CREBH in inflammation enhances mRNA and protein expression of apoB. CREBH presents a potential novel therapeutic target for hyperlipoproteinemia. PMID: 28455595
    4. key positive regulator of TGF-beta2 transcription in hepatitis C virus-infected cells PMID: 28621467
    5. TLR-4 interacts with CREBH to modulate high-density lipoprotein in response to bacterial endotoxin. PMID: 27637329
    6. CREBH functions as a key metabolic regulator that controls glucose homeostasis across the circadian cycle or under metabolic stress PMID: 28461393
    7. Ldlr(-/-) Creb3l3(-/-) mice developed significantly more atherosclerotic lesions in the aortas than Ldlr(-/-) mice. PMID: 27417587
    8. studies reveal that CREBH functions as a circadian-regulated liver transcriptional regulator that integrates energy metabolism with circadian rhythm. PMID: 27507854
    9. Very Low Density Lipoprotein (VLDL) assembly and CREBH activation play key roles in the response to hepatic steatosis by up-regulating apoA-IV and promoting assembly and secretion of larger, more triglyceride - enriched VLDL particles. PMID: 27655915
    10. fasting or glucagon stimulation modulates lipid homeostasis through acetylation of CREBH. PMID: 26438600
    11. Overexpression of nuclear CREB3L3 induced systemic lipolysis, hepatic ketogenesis, and insulin sensitivity with increased energy expenditure. PMID: 25233440
    12. CREBH-Fsp27beta axis is important for regulating lipid droplet dynamics and triglyceride storage in the liver PMID: 25125366
    13. CREBH activated by HBx interacted with HBx protein, leading to a synergistic effect on the expression of AP-1 target genes and the proliferation of hepatocellular carcinoma cells and mouse primary hepatocytes. PMID: 25428452
    14. Alpha lipoic acid (ALA) increases hepatic FGF21 expression via up-regulation of CREBH, identifying ALA as a novel positive regulator of FGF21 PMID: 25449271
    15. Orphan nuclear receptor Errgamma induces C-reactive protein gene expression through induction of ER-bound Bzip transmembrane transcription factor CREBH. PMID: 24466039
    16. analysis of the transcriptional regulatory axis of CREBH-PPARalpha-FGF21 that has a role in maintaining lipid homeostasis under metabolic stress PMID: 24424044
    17. These data demonstrate that CREBH is a positive regulator of CYP2B in response to sulpyrine administration, which possibly results in fatal shock. PMID: 23409047
    18. Data indicate that knockdown of Crebh or Cb1r antagonism attenuated 2-arachidonoylglycerol mediated induction of Lipin1 gene expression and decreased diacylglycerol production in liver and subsequently restored insulin receptor signaling. PMID: 22989885
    19. Studies indicate that CREB-H-deficient mice showed hypertriglyceridemia. PMID: 22262056
    20. Endoplasmic reticulum-tethered transcription factor cAMP responsive element-binding protein, hepatocyte specific, regulates hepatic lipogenesis, fatty acid oxidation, and lipolysis upon metabolic stress in mice. PMID: 22095841
    21. a transcription factor that has a crucial role in triglyceride metabolism PMID: 21666694
    22. CREBH plays a crucial role in the regulation of hepatic glucose metabolism in mammals. PMID: 20374965
    23. N-linked glycosylation is required for full activation of CREB-H through intramembrane proteolysis. PMID: 20356926
    24. Activation of CREBH at fasting through fatty acids and PPARalpha suggest that CREBH is involved in nutritional regulation. PMID: 20006574
    25. CREB-H is a liver-enriched bZIP transcription factor that may be involved in hepatic physiology and hepatocarcinogenesis. PMID: 15800215
    26. molecular mechanism for activation of an ER-localized transcription factor, CREBH PMID: 16469704
    27. HNF4alpha has a role in controlling the acute phase response of the liver induced by ER stress by regulating expression of CrebH. PMID: 18704925

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  • 亚细胞定位：
    Endoplasmic reticulum membrane; Single-pass type II membrane protein.; [Processed cyclic AMP-responsive element-binding protein 3-like protein 3]: Nucleus.
  • 蛋白家族：
    BZIP family, ATF subfamily
  • 组织特异性：
    Exclusively expressed in adult liver (at protein level).
  • 数据库链接：

    KEGG: mmu:208677

    STRING: 10090.ENSMUSP00000112836

    UniGene: Mm.294693