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  4. Recombinant Mouse Coagulation factor XIII A chain (F13a1)

Recombinant Mouse Coagulation factor XIII A chain (F13a1)

  • 货号：
    CSB-YP806833MO
  • 规格：
  • 来源：
    Yeast
  • 其他：
  • 货号：
    CSB-EP806833MO
  • 规格：
  • 来源：
    E.coli
  • 其他：
  • 货号：
    CSB-EP806833MO-B
  • 规格：
  • 来源：
    E.coli
  • 共轭：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 货号：
    CSB-BP806833MO
  • 规格：
  • 来源：
    Baculovirus
  • 其他：
  • 货号：
    CSB-MP806833MO
  • 规格：
  • 来源：
    Mammalian cell
  • 其他：

产品详情

  • 纯度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 别名：
    F13a1; F13aCoagulation factor XIII A chain; Coagulation factor XIIIa; EC 2.3.2.13; Protein-glutamine gamma-glutamyltransferase A chain; Transglutaminase A chain
  • 种属：
    Mus musculus (Mouse)
  • 蛋白长度：
    Full Length of Mature Protein
  • 表达区域：
    39-732
  • 氨基酸序列
    GV NLKDYLNVTA VHLFKERWDS NKIDHHTDKY DNNKLIVRRG QTFYIQIDFN RPYDPRKDLF RVEYVIGRYP QENKGTYIPV PVVKELQSGK WGAKVIMNED RSVRLSVQSS PECIVGKFRM YVAVWTPYGI LRTRRDPETD TYILFNPWCE EDAVYLDDEK EREEYVLNDI GVIFYGDFKD IKSRSWSYGQ FEDGILDTCL YVMDKAEMDL SGRGNPIKVS RVGSAMVNAK DDEGVLVGSW DNVYAYGIPP SAWTGSVDIL LEYRSSETPV RYGQCWVFAG VFNTFLRCLG IPARVITNYF SAHDNDANLQ MDIFLEEDGN VSSKLTKDSV WNYHCWNEAW MTRPDLPVGF GGWQAVDSTP QENSDGMYRC GPASVQAVKH GHVCFQFDAP FVFAEVNSDL VYITAKQDGT HVVEAVDATH IGKLIVTKQI GGDGMQDITD TYKFQEGQEE ERLALETALM YGAKKTLNTE GVVKSRSDVT MNFDVENAVL GKDFKVTITF QNNSSNLYTI LAYLSGNITF YTGVSKKEFK KESFEETLDP FSSKKKEVLV RAGEYMSHLL EQGFLHFFVT ARINESRDVL AKQKSIILTI PKITIKVRGA AMVGSDMVVT VEFTNPLKET LQNVWIHLDG PGVMRPKRKV FREIRPNTTV QWEEVCRPWV SGHRKLIASM TSDSLRHVYG ELDLQIQRRP TM
  • 蛋白标签：
    Tag type will be determined during the manufacturing process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 产品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 复溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 储存条件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保质期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 货期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事项：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

产品评价

靶点详情

  • 功能：
    Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin.
  • 基因功能参考文献：
    1. Factor XIII-A and TG2 regulate resorption, adipogenesis and plasma fibronectin homeostasis in bone and bone marrow. PMID: 28387755
    2. Suggest that resident macrophages maintain plasma FXIII-A and exclude the platelet lineage as a major contributor. PMID: 28596376
    3. These findings provide insight into assembly of the fibrinogen/FXIII-A2B2 complex in both physiologic and therapeutic situations. PMID: 27561317
    4. Mast cells have the ability to produce and degrade FXIIIA depending on their chymase expression profile: mast cells expressing chymase degrade FXIIIA, whereas mast cells that do not express chymase mainly produce FXIIIA PMID: 27302551
    5. A lack of factor XIII leads to prolonged clotting times, increased signs of inflammation, and elevated bacterial dissemination in streptococcal skin diseases. PMID: 27338836
    6. FXIII is a significant determinant of mucosal healing and clinical outcome following inflammatory colitis induced mucosal injury PMID: 26098308
    7. These findings expose a newly recognized, essential role for fibrin crosslinking during whole blood clot formation and consolidation and establish FXIIIa activity as a key determinant of thrombus composition and size. PMID: 26324704
    8. related to islet dysfunction during the development of type 2 diabetes PMID: 26018251
    9. 5-HT inhibits Factor XIII-A-mediated plasma fibronectin matrix assembly and crosslinking in osteoblast cultures via direct competition with transamidation PMID: 25460579
    10. High Transglutaminase factor XIII promotes arthritis through mechanisms linked to inflammation and bone erosion. PMID: 25336631
    11. Fibrinogen from mice harboring the Fibgamma390-396A mutation exhibited reduced binding to FXIII, and plasma from these mice exhibited delayed FXIII activation and fibrin crosslinking, indicating these residues mediate FXIII binding and activation. PMID: 24983320
    12. FXIII-A serves as a preadipocyte-bound proliferation/differentiation switch that mediates effects of hepatocyte-produced circulating pFN. PMID: 24934257
    13. Physiological significance of mouse TG2 and Factor XIII through identification of substrate proteins in MC3T3-E1 cells. PMID: 22045386
    14. Studies indicate that in FXIII-A-knockout mice, tail-tip bleeding times are doubled and clot stability, assessed by thromboelastography, was impaired compared with wild-type mice. PMID: 23075332
    15. FXIIIA mRNA was regulated by the MAP kinase pathway. PMID: 21959563
    16. Data indicate that FXIIIa-targeted probe signals showed good overlap with immune-fluorescent fibrin staining images. PMID: 22272319
    17. factor XIIIA transglutaminase activity regulates osteoblast matrix secretion and deposition by affecting microtubule dynamics PMID: 21283799
    18. Inhibition of TG2 and FXIIIA during early development of lesions reduced the macrophage content in the media of atherosclerotic vessels, while not affecting lesion size or geometric remodeling PMID: 20810110
    19. Knockout mouse studies suggest that plasma FXIII-A does not derive primarily (if at all) from circulating platelets and indeed may not derive from the megakaryocyte lineage. PMID: 20086247
    20. All FXIII2/2 and FXIII2/+ mice died within 5 days after MI from left ventricular (LV) rupture and had locally reduced levels of FXIII. PMID: 17183677
    21. Factor XIII A subunit deficieny is associated with impaired clot retraction PMID: 19996413
    22. impaired clot stabilization in FXIII-A mutant mice PMID: 12529747
    23. Maternal FXIII plays a critical role in uterine hemostasis and maintenance of the placenta during gestation. PMID: 12933578
    24. platelet FXIII and calpain have roles in regulating integrin alpha(IIb)beta3 adhesive function PMID: 15131115
    25. FXIII has an essential role in wound repair and remodeling PMID: 16113836
    26. analysis of the expression, localization and activity of TG2 and FXIIIA in mineralizing tissues [review] PMID: 16368540
    27. Results demonstrate that MC3T3-E1/C14 osteoblasts express two transglutaminase isoforms--TG2 and FXIIIA. PMID: 16469487
    28. the entire FXIIIA gene is expressed, thus indicating that the 37-kDa FXIIIA is not a splice variant but a product of posttranslational proteolytic processing. PMID: 17341477
    29. Carditis and fibrosis in FXIII-deficient mice might be caused by a faulty or delayed reparative process that was initiated by abnormal haemorrhagic events within heart tissue. PMID: 18278192
    30. FXIIIa supports the early survival of micrometastases by a mechanism linked to NK cell function PMID: 18315549

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  • 亚细胞定位：
    Cytoplasm. Secreted.
  • 蛋白家族：
    Transglutaminase superfamily, Transglutaminase family
  • 数据库链接：

    KEGG: mmu:74145

    STRING: 10090.ENSMUSP00000048667

    UniGene: Mm.235105